Abstract: The present invention encompasses methods and kits employing pattern recognition receptor expression as a measure of systemic health in a subject afflicted with an oral health condition. In particular, the present invention is directed to methods involving measurement of the expression levels of one or more Pattern Recognition Receptors including but not limited to Toll-Like Receptors, myeloid differentiation primary response gene 88 (MyD88), and Nucleotide Binding oligomerization domain containing protein 1 (NOD1), in a companion animal, e.g., a dog or a cat, afflicted with an oral health condition. The described methods enable evaluation of the systemic health of the animal afflicted with an oral health condition by measuring expression levels of the indicated genes as compared to suitable controls.

Abstract: The present invention encompasses methods and kits employing pattern recognition receptor expression as a measure of systemic health in a subject afflicted with an oral health condition. In particular, the present invention is directed to methods involving measurement of the expression levels of one or more Pattern Recognition Receptors including but not limited to Toll-Like Receptors, myeloid differentiation primary response gene 88 (MyD88), and Nucleotide Binding oligomerization domain containing protein 1 (NOD1), in a companion animal, e.g., a dog or a cat, afflicted with an oral health condition. The described methods enable evaluation of the systemic health of the animal afflicted with an oral health condition by measuring expression levels of the indicated genes as compared to suitable controls.

Abstract: The present invention encompasses methods and kits employing pattern recognition receptor expression as a measure of systemic health in a subject afflicted with an oral health condition. In particular, the present invention is directed to methods involving measurement of the expression levels of one or more Pattern Recognition Receptors including but not limited to Toll Like Receptors, myeloid differentiation primary response gene 88 (MyD88), and Nucleotide Binding oligomerization domain containing protein 1 (NOD1), in a companion animal, e.g., a dog or a cat, afflicted with an oral health condition. The described methods enable evaluation of the systemic health of the animal afflicted with an oral health condition by measuring expression levels of the indicated genes as compared to suitable controls.

Abstract: The current invention relates to animal food kibbles having a primarily disc shape and including botanicals such as curcumin. The current invention also relates to methods to reduce oral inflammation in an animal by feeding the animal with the food kibbles. The disc-shaped food kibbles induce a reduction of oral inflammation in the animal compared to control food kibbles having a different shape.

Abstract: The current invention relates to animal food kibbles having a primarily disc shape and including botanicals such as curcumin. The current invention also relates to methods to reduce oral inflammation in an animal by feeding the animal with the food kibbles. The disc-shaped food kibbles induce a reduction of oral inflammation in the animal compared to control food kibbles having a different shape.

Abstract: The present invention encompasses methods and kits employing pattern recognition receptor expression as a measure of systemic health in a subject afflicted with an oral health condition. In particular, the present invention is directed to methods involving measurement of the expression levels of one or more Pattern Recognition Receptors including but not limited to Toll Like Receptors, myeloid differentiation primary response gene 88 (MyD88), and Nucleotide Binding oligomerization domain containing protein 1 (NOD1), in a companion animal, e.g., a dog or a cat, afflicted with an oral health condition. The described methods enable evaluation of the systemic health of the animal afflicted with an oral health condition by measuring expression levels of the indicated genes as compared to suitable controls.

Abstract: The present disclosure provides methods and compositions comprising ascorbyl esters for the treatment or reduction of dental conditions in an animal. A pet food composition of the disclosure can be a dry food composition comprising (i) a matrix of ingredients nutritionally or organoleptically adapted for the animal and (ii) an outer coating layer, wherein the outer coating layer is applied to the matrix as a solution comprising an effective amount of an ascorbic acid fatty acid ester dissolved in a plant oil. One disclosed method of treatment or reduction involves feeding an animal in need of such treatment a dry pet food composition of the disclosure. A second disclosed method comprises applying to one or more surfaces of one or more teeth of an animal in need of such treatment, an effective amount of a solution comprising an ascorbic acid fatty acid ester dissolved in a plant oil.

Abstract: The present disclosure provides methods and compositions for treating or reducing a dental condition in an animal, particularly in canine and feline companion animals. Compositions useful in the disclosed methods comprise an effective amount of lactic acid. The disclosed compositions may also contain oral health promoting effective amounts of at least one antioxidant. Dental conditions treated or reduced according to the disclosed methods include dental plaque, calculus, tooth staining, halitosis, stomatitis, gingivitis, periodontitis, and combinations thereof.

Abstract: An oral care composition containing a synergistic antiplaque/antigingivitis combination of a nonionic halogenated diphenyl ether compound such as Triclosan and an extract of Magnolia Officinalas containing honokiol and magnolol.

Abstract: An oral antiplaque composition comprising an orally acceptable vehicle and an effective antiplaque amount of 4-alkoxy substituted 2-hydroxy benzophenone compound having the following formula: where X, Y, X′ and Y′ represent hydrogen, and lower straight chain or branched C1-C4 alkyl radicals, C3-C6 cycloalkyls and R represents lower C1-C8 alkoxy radicals.

Abstract: An antibacterial, anti-inflammatory compound for use in oral products, of the formulae: ##STR1## Wherein: R.sub.1 and R.sub.2 are straight chain or branched alkyl substituents or cycloalkyls with one or more alkyl substituents.

Abstract: A process for the continuous production of cyclodextrins employs as a feedstock an aqueous solution of partially hydrolyzed starch with a dextrose equivalent between about 10 and about 15 as the feedstock for an immobilized cyclodextrin glycosyltransferase. In one variant the feedstock is sent to a membrane which removes cyclodextrins and glucose and the retentate is recycled to an immobilized glycosyltransferase so as to effectively utilize the feedstock. In another variant the effluent is passed through a water immiscibled liquid organic compound which forms a solid insoluble complex with cyclodextrins, the solids are continually removed, and the aqueous phase is recycled to an immobilized cyclodextrin glycosyltransferase as in the prior variant.

Abstract: The yield of cyclodextrins formed in the hydrolysis of starch catalyzed by a cyclodextrin glycosyltransferase can be substantially increased by the addition of certain water-soluble solutes. Alcohols containing 1 to 6 carbon atoms form one such class, with ethanol and isopropyl alcohol being especially effective. Where an immobilized cyclodextrin glycosyltransferase is used yields of beta-cyclodextrin can be increased from approximately 20% to almost 40% using 15% isopropyl alcohol in a thinned starch feedstock, with glucose production being increased by only about 25%.