Abstract: This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R1, R2, R3 have meanings given in the description.

Abstract: This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R1, R2, R3, R3a have meanings given in the description.

Abstract: This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R1, R2, R3 have meanings given in the description.

Abstract: This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R1, R2, R3 have meanings given in the description.

Abstract: This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R1, R2, R3 have meanings given in the description.

Abstract: Disclosed are substituted quinolines of formula 1 wherein R1 and R2 are defined herein, the processing of making and using the same.

Abstract: The present invention relates to new dihydropteridinones of general formula (12) wherein the groups R1 to R5 and L, n, and m have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.

Abstract: The invention relates to a plug connector with a first plug housing and a second plug housing which are plugged into each other, wherein there is provided in the first plug housing a contact-securing means which can be brought from a pre-locking position into an end position in which the contact-securing means protects contacts of the first plug housing from accidental detachment, there being movably mounted on the second plug housing an actuating means which is operatively connected to the first plug housing. The first and the second plug housing being plugged together as a result of a movement of the actuating means from an open position into an end position, and the contact-securing means has an obstructing element, the obstructing element protruding into the path of movement of the actuating means or the first plug housing and preventing plugging-together of the first plug housing and the second plug housing when the contact-securing means is not in the end position.

Abstract: A single-piece electrical contact element is provided, having a substantially cylindrical contact tube for resiliently receiving a contact pin. A contact tube main part extends over a substantial part of the contact tube length and a first circumferential sub-region of the contact tube circumference. At least one radially resilient spring arm, connected to one circumferential end of the contact tube main part extends over a second circumferential sub-region of the contact tube circumference. The spring arm projects radially outwardly in a first circumferential region adjacent to the contact tube main part and has a cylindrical free-standing circumferential end region.

Abstract: A single-piece electrical contact element is provided, having a substantially cylindrical contact tube for resiliently receiving a contact pin. A contact tube main part extends over a substantial part of the contact tube length and a first circumferential sub-region of the contact tube circumference. At least one radially resilient spring arm, connected to one circumferential end of the contact tube main part extends over a second circumferential sub-region of the contact tube circumference. The spring arm projects radially outwardly in a first circumferential region adjacent to the contact tube main part and has a cylindrical free-standing circumferential end region.