Abstract: This invention relates to compounds of general Formula (I) and pharmaceutically acceptable salts thereof, in which R1, R2, R2A, R2B, R3, R4, R5A, R5B, R6, R7, R8, R9, p, q and r are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: A metered smoking apparatus includes a burnable media including indicia that visually represent a plurality of smokable units of a smokable substance or an active ingredient thereof, each of the smokable units corresponding to a same predetermined quantity of the smokable substance or the active ingredient thereof, and when the smokable substance is rolled within the burnable media, the burnable media is configured such that the indicia are sequentially burned in a burn line direction that is a direction in which a burn line burns when the metered smoking apparatus is smoked, to thereby indicate consumption of the predetermined quantity on a unit-by-unit basis.

Abstract: A pest control and/or detection system generally includes an electrically conductive bait matrix including at least one carrier material that is at least one of palatable, a phagostimulant and/or consumable and/or displaceable by pests, and a plurality of electrically conductive particles. The electrically conductive particles are substantially randomly interspersed throughout the at least one carrier material. The at least one carrier material includes a thermoplastic material and/or a resin.

Abstract: An inhalation device for inhaling a vaporized substance that includes metering capabilities to inform a user when a particular amount of substance has been consumed. The inhalation device can include an inlet, an outlet, a channel positioned between the inlet and outlet. The device can further include an atomizer positioned between the inlet and the outlet and configured to vaporize an unvaporized substance into a vaporized substance, where the vaporized substance flows downstream from the atomizer to the outlet via the channel. The inhalation device can further include an airflow sensor positioned upstream of the flow of the vaporized substance, where the airflow sensor is configured to acquire information on the flow of air from the inlet.

Abstract: An inhalation device for inhaling a vaporized substance that provides security and/or childproof capability that includes an inlet, an outlet, a channel positioned between the inlet and outlet, a security mechanism capable of configuring the inhalation device in a locked mode and an unlocked mode, where the inhalation device is configured to vaporize an unvaporized substance when the security mechanism configures the inhalation device in the unlocked mode, where the security mechanism is configured to prevent the inhalation device from vaporizing an unvaporized substance when the security mechanism configures the inhalation device in the locked mode.

Abstract: Aspects are generally directed to a compact and low-noise magnetic field detector, methods of operation, and methods of production thereof. In one example, a magnetic field detector includes a proof mass, a magnetic dipole source coupled to the proof mass, and a substrate having a substrate offset space defined therein, the proof mass being suspended above the substrate offset space. The magnetic field detector further includes a sense electrode disposed on the substrate within the substrate offset space and positioned proximate the proof mass, the sense electrode being configured to measure a change in capacitance relative to the proof mass from movement of the proof mass in response to a received magnetic field at the magnetic dipole source. The magnetic field detector includes a control circuit coupled to the sense electrode and configured to determine a characteristic of the magnetic field based on the measured change in capacitance.

Abstract: Aspects are generally directed to a compact and low-noise electric field detector, methods of operation, and methods of production thereof. In one example, an electric field detector includes a proof mass, a source of concentrated charge coupled to the proof mass, and a substrate having a substrate offset space defined therein, the proof mass being suspended above the substrate offset space. The electric field detector further includes a sense electrode disposed on the substrate within the substrate offset space and proximate the proof mass, the sense electrode being configured to measure a change in capacitance relative to the proof mass from movement of the proof mass in response to a received electric field at the source of concentrated charge. The electric field detector includes a control circuit coupled to the sense electrode and configured to determine a characteristic of the electric field based on the measured change in capacitance.

Abstract: A pest control and detection system generally includes an electrically conductive bait matrix including at least one carrier material that is at least one of palatable, a phagostimulant, consumable, and displaceable by pests, and a plurality of electrically conductive particles. The electrically conductive particles are substantially randomly interspersed throughout the at least one carrier material. The at least one carrier material includes at least one of a thermoplastic material and a resin.

Abstract: An automatic key duplicating machine is disclosed. A master key identification module includes at least one key blade cross-section detector with a plurality of sliding elements, the master key identification module being configured to determine a key type for a master key based at least in part on engagement of the plurality of sliding elements with a blade profile of the master key. A key extraction module is configured to retrieve a key blank of an identified key type. A key cutting module is configured to cut the key blank in accordance with a tooth pattern of the master key.

Abstract: This disclosure provides systems and methods for delivering a neural stimulation pulse. A neural implant device can include an energy harvesting circuit configured to receive an input signal and generate an electrical signal based on the received input signal. A diode rectifier in series with the energy harvesting circuit can rectify the electrical signal. The energy harvesting circuit and the diode rectifier can be encapsulated within a biocompatible electrically insulating material. A neural electrode can be exposed through the biocompatible electrically insulating material. The neural electrode can be configured to deliver a neural stimulation pulse. The neural implant device can have a volume that is less than about 1.0 cubic millimeter.

Abstract: The present application relates to K-ras mutations, to polynucleotides encoding mutant K-ras polypeptides, and to methods of identifying K-ras mutations. The present application also relates to methods of diagnosing cancer; and methods and kits for predicting the usefulness of anti-EGFr specific binding agents in the treatment of tumors.

Abstract: A key-duplicating system comprises a network that includes a multiplicity of kiosks at a multiplicity of different locations, each of the kiosks having a customer interface and a processor coupled to the customer interface. A remote central server coupled to the kiosks is adapted to receive, from the kiosks, information identifying master keys to be duplicated.

Abstract: A pest control and detection system generally includes an electrically conductive bait matrix including at least one carrier material that is at least one of palatable, a phagostimulant, consumable, and displaceable by pests, and a plurality of electrically conductive particles. The electrically conductive particles are substantially randomly interspersed throughout the at least one carrier material. The at least one carrier material includes at least one of a thermoplastic material and a resin.

Abstract: Aspects are generally directed to systems and methods that integrate contactless electric field detectors to measure biophysical signals generated by a body. In one example, a biophysical sensing system includes a sensing assembly including an array of contactless electric field detectors, each of the contactless electric field detectors being configured to sense a corresponding component of an electric field generated by a body, a control system to receive sensor data indicative of the components of the electric field sensed by each of the contactless electric field detectors, the control system being configured to generate an estimate of the electric field based on the sensor data, and a feedback system coupled to at least the control system, the feedback system including at least one feedback interface, the feedback system being configured to operate the feedback interface to provide feedback based on the estimate of the electric field.

Abstract: A method of duplicating a key includes receiving a master key in a key duplicating machine. The machine automatically detects a cross sectional profile of the master key. The machine automatically determines, based on the detected cross sectional profile, a type and model of the master key. The machine automatically selects a key blank that matches the type and model of the master key, and then automatically cuts the selected key blank to duplicate a key tooth pattern of the master key.

Abstract: This invention relates to compounds of general Formula (I) and pharmaceutically acceptable salts thereof, in which R1, R2, R2A, R2B, R3, R4, R5A, R5B, R6, R7, R8, R9, p, q and r are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: A method for comprehensive user/event matching or recommendations is described. The method includes a network environment which receives one or more pieces of user data, event data, or social data from users or third party data sources, determining the relevance of the data for users, and displaying the identified data to user in the form of recommendations.

Abstract: This disclosure provides systems and methods for delivering a neural stimulation pulse. A neural implant device can include an energy harvesting circuit configured to receive an input signal and generate an electrical signal based on the received input signal. A diode rectifier in series with the energy harvesting circuit can rectify the electrical signal. The energy harvesting circuit and the diode rectifier can be encapsulated within a biocompatible electrically insulating material. A neural electrode can be exposed through the biocompatible electrically insulating material. The neural electrode can be configured to deliver a neural stimulation pulse. The neural implant device can have a volume that is less than about 1.0 cubic millimeter.

Abstract: This disclosure provides systems and methods for delivering a neural stimulation pulse. A neural implant device can include an energy harvesting circuit configured to receive an input signal and generate an electrical signal based on the received input signal. A diode rectifier in series with the energy harvesting circuit can rectify the electrical signal. The energy harvesting circuit and the diode rectifier can be encapsulated within a biocompatible electrically insulating material. A neural electrode can be exposed through the biocompatible electrically insulating material. The neural electrode can be configured to deliver a neural stimulation pulse. The neural implant device can have a volume that is less than about 1.0 cubic millimeter.

Abstract: An inhalation device for inhaling a vaporized substance that includes metering capabilities to inform a user when a particular amount of substance has been consumed. The inhalation device can include a sensor that senses the vaporized substance and a processor that utilizes data from the sensor to meter the amount consumed. The inhalation device can also define a session, which is a time in which a user can consume a particular amount. During the session, a user can start and stop inhaling and resume inhaling. When the user stops inhaling the inhalation device will halt vapor production and will resume production when the user resumes inhaling.