Abstract: The invention provides anti-Notch2 antibodies and conjugates and methods of using the same.

Abstract: Resource state validation may be performed for access management policies by an identity and access management system. An access management policy associated with an account for network-based services may be received and validated according to resource state obtained for resources associated with the account. A correction for a portion of the access management policy may be identified according to the validation and provided via an interface for the identity and access management system.

Abstract: The invention provides anti-Notch2 antibodies and methods of using the same.

Abstract: A method for determining the presence, absence or amount of two or more target polynucleotides in a sample comprising additional components, the method comprising: (i) contacting the sample with a panel of two or more probes under conditions suitable for hybridisation of the target polynucleotides to the probes, wherein: (a) each probe comprises a non-hybridisation region and a hybridisation region that specifically hybridises to one of the target polynucleotides to form a hybridised probe; and (b) the hybridisation region of a probe of the panel comprises one or more non-natural nucleotides; (ii) contacting the sample prepared in step (i) with a transmembrane pore through which a single stranded polynucleotide but not a double stranded polynucleotide can pass and applying a potential difference to the transmembrane pore such that the hybridised probes in the sample interact with the pore; (iii) measuring current blockades having a duration within a defined window, wherein: (a) the one or more non-natu

Abstract: An access door may include a core, stiles on opposites sides of the core, an elongated panel extending transversely between the stiles, wherein a major face of the door between the stiles defines one or more recessed pockets along a top edge of the elongated panel between and the stiles and the elongated panel, and a notch formed into the top edge of the elongated panel and extending along at least one of the recessed pockets, the notch extending downwardly into the top edge of the elongated panel so as to form a lip in the top edge of the elongated panel with the notch positioned between the lip and the one or more recessed pockets, the lip and the notch of the elongated panel together forming an accessory rail, wherein the accessory rail is configured to receive and support a complementarily configured hanger base of an accessory hanger.

Abstract: A through-bore spool apparatus for use in deploying multiple spoolable media in a bore is disclosed. The through-bore spool apparatus comprises a first spool comprising a first spool axis and a first spoolable medium wound around the first spool axis, and a second spool comprising a second spool axis and a second spoolable medium wound around the second spool axis. The first and second spoolable media are de-spoolable simultaneously from the respective first and second spools during movement of the through-bore spool apparatus along a bore.

Abstract: Methods, systems, and computer-readable media for analysis of role reachability using policy complements are disclosed. An access control analyzer determines two nodes in a graph that potentially have a common edge. The nodes correspond to roles in a provider network, and the roles are associated with first and second access control policies that grant or deny access to resources. The access control analyzer performs a role reachability analysis that determines whether the first role can assume the second role for a particular state of one or more key-value tags. The role reachability analysis determines a third access control policy authorizing a negation of a role assumption request for the second role. The role reachability analysis performs analysis of the third access control policy with respect to a role assumption policy for the second role for the particular state of the one or more key-value tags.

Abstract: The invention provides a method of detecting a target polynucleotide in a sample comprising: (a) contacting the sample with a guide polynucleotide that binds to a sequence in the target polynucleotide and a polynucleotide-guided effector protein, wherein the guide polynucleotide and polynucleotide-guided effector protein form a complex with any target polynucleotide present in the sample; (b) contacting the sample with a membrane comprising a transmembrane pore; (c) applying a potential to the membrane; and (d) monitoring for the presence or absence of an effect resulting from the interaction of the complex with the transmembrane pore to determine the presence or absence of the complex, thereby detecting the target polynucleotide in the sample.

Abstract: Methods, systems, and computer-readable media for generating access control policies using static analysis are disclosed. An access control policy generator performs static analysis of program code of a software product. The static analysis identifies one or more calls to one or more external components in the program code. The access control policy generator determines a mapping of the one or more calls to one or more actions. The one or more actions are selected from a plurality of known actions supported by an access control policy manager. The access control policy generator generates an access control policy associated with the software product. The access control policy comprises one or more permissions with respect to the one or more external components. The access control policy permits the software product to access the plurality of external components using the access control policy manager during execution of the software product.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training an action selection neural network used to select actions to be performed by an agent interacting with an environment. One of the systems includes (i) a plurality of actor computing units, in which each of the actor computing units is configured to maintain a respective replica of the action selection neural network and to perform a plurality of actor operations, and (ii) one or more learner computing units, in which each of the one or more learner computing units is configured to perform a plurality of learner operations.

Abstract: A rotor blade retention assembly is configured to connect a rotor blade to a central hub comprising a hub arm coupled to and extending radially outward from a hub bowl. The hub arm includes a hub arm lug. The rotor blade retention assembly includes a tension-torsion strap with an inboard end and an outboard end, the inboard end including an inboard pin hole and the outboard end including an outboard pin hole. The rotor blade retention assembly further includes an inboard blade pin and an outboard blade pin. The inboard blade pin is configured to extend through the hub arm lug and the inboard pin hole and to couple the inboard end of the tension-torsion strap to the hub arm. The outboard blade pin is configured to extend through a blade lug of a rotor blade and the outboard pin hole and to couple the outboard end of the tension-torsion strap to the rotor blade.

Abstract: An engine control unit of a multi-fuel is provided. The engine consumes a mixture of a first combustion fuel and a second combustion fuel. The engine control unit includes hardware circuitry that includes one or more processors configured to calculate an autoignition delay of the mixture of the air and the second combustion fuel based on current operating conditions of the multi-fuel engine. The one or more processors also are configured to calculate an upper limit on an amount of the second combustion fuel that is supplied to the multi-fuel engine based on the autoignition delay that is calculated.

Abstract: Example devices and methods for compensating for monitoring a surge protection device are provided. In some embodiments, a device is configured to couple to a surge protection device. The device comprises a processor that is capable of sending a DC current signal. A serial data interface is electrically connected to the processor and includes at least one shift register. The device also comprises a multiplexer coupled to the serial data interface. The serial data interface is operable to direct the DC current through the multiplexer. The device also comprises an analog to digital converter (optionally embedded within the processor) that is operable to output a digital signal corresponding to a voltage induced by the DC current signal. Returned DC signals represent surge protection device's health and a multitude of other surge module information.

Abstract: The invention relates to a new method of determining in a sample the presence or absence of one or more analyte members of a group of two or more analytes. The invention therefore relates to a multiplex assay for determining the presence or absence of each analyte in a group of multiple analytes. The assay uses aptamers and transmembrane pores.

Abstract: Apparatus and methods for manufacturing compostable, biodegradable drink straws from polyhydroxyalkanoate (PHA) material are disclosed herein. Such apparatus may include a hopper that contains raw PHA material, an extruder that receives the raw PHA material from the hopper and produces extruded PHA material, one or more waters baths that cool the extruded PHA material, a puller that pulls a tubular stream of PHA material through the system, and a cutter that is configured to cut the stream of PHA material into finished straws. The finished straws may be soil- and marine-biodegradable, as well as home- and industrial-compostable.

Abstract: Techniques for intent-based access control are described. A method of intent-based access control may include receiving, via a user interface of an intent-based governance service, one or more intent statements associated with user resources in a provider network, the one or more intent statements expressing at least one type of action allowed to be performed on the user resources, compiling the one or more intent statements into at least one access control policy, and associating the at least one access control policy with the user resources.

Abstract: A vehicle suspension system includes left and right control arm assemblies each having a wheel mount structure, an upper control arm, and a lower control arm. Each control arm includes a first end configured to be pivotably connected to a frame structure of a vehicle and a second end rotatably connected to the wheel mount structure. The vehicle suspension system also includes a transverse leaf spring having an elongated body extending between the control arm assemblies, outer mounting brackets respectively connecting left and right ends of the elongated body to the left and right control arm assemblies, and one or more inner mounting brackets located between the outer mounting brackets. The transverse leaf spring is contoured such that a contoured portion of the elongated body deviates in a downward direction in order to extend below an electric drive system disposed within an internal space between rails of the frame structure.

Abstract: An illumination system is provided for an access door may include an elongated illumination housing configured to be coupled to at least one of an upstanding jamb and a corresponding jamb casing extending along the one side of the access door, an elongated light transmissive cover coupled to the illumination housing, an elongated light pipe received within the illumination housing, an illumination source housing operatively coupled to one end of the light pipe, an illumination source disposed within the illumination source housing and configured to produce and transmit visible light into the light pipe so as to be visible through the light transmissive cover, a source of electrical power, and a control unit configured to selectively apply electrical power from the source of electrical power to the illumination source to produce the visible light.

Abstract: A method provides for operating an engine configured to use a plurality of differing fuels. The method includes determining a fuel combustion ratio of the plurality of differing fuels associated with at least one engine cylinder of the engine based at least in part on one or more of a plurality of characteristic profiles. This maintains one or more of a plurality of actual values associated with usage of the plurality of differing fuels relative to defined corresponding threshold values. The fuel combustion ratio includes a ratio of the plurality of differing fuels to be delivered to the at least one engine cylinder. A fuel delivery system delivers the plurality of differing fuels to the at least one engine cylinder based on the fuel combustion ratio.

Abstract: A rotor blade retention assembly includes a central hub, a rotor blade including an upper outer surface, a lower outer surface, a blade hole, and a proximal end coupled to the central hub, a strap member extending along a portion of the rotor blade such that a distal end receiving portion extends into the blade hole, and a retainer assembly disposed within the blade hole and coupled to the strap member. The retainer assembly includes an upper bushing and a lower bushing slidably disposed within the blade hole. The upper bushing includes a counterbored portion. The retainer assembly also includes an outboard blade pin disposed within the distal end receiving portion and includes a blade pin inner cavity.