Patents by Inventor Daniel Henry Densham

Daniel Henry Densham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYNUCLEOTIDE SEQUENCING METHODS
    Publication number: 20170022556
    Abstract: Methods for determining the sequence of a polynucleotide comprising the steps of (i) contacting a polynucleotide processive enzyme immobilised in a fixed position, with a target polynucleotide under conditions sufficient to induce enzyme activity; (ii) detecting an effect consequent on the interaction of the enzyme and the polynucleotide, wherein the effect is detected by measurement of a non-linear optical signal or a linear signal coupled to a non-linear signal.
    Type: Application
    Filed: September 29, 2016
    Publication date: January 26, 2017
    Inventor: Daniel Henry DENSHAM
  • Polynucleotide sequencing method
    Patent number: 9476094
    Abstract: The subject invention pertains to a method for determining the sequence of a polynucleotide comprising the steps of (i) contacting a polynucleotide processive enzyme immobilised in a fixed position, with a target polynucleotide under conditions sufficient to induce enzyme activity; (ii) detecting an effect consequent on the interaction of the enzyme and polynucleotide, wherein the effect is detected by measurement of a non-linear optical signal or a linear signal coupled to a non-linear signal.
    Type: Grant
    Filed: May 20, 2002
    Date of Patent: October 25, 2016
    Assignee: GEN-PROBE INCORPORATED
    Inventor: Daniel Henry Densham
  • DNA SEQUENCING METHOD
    Publication number: 20120214164
    Abstract: A method for determining the sequence of a polynucleotide, the method relying on the detection of a conformational change in an enzyme that interacts with and processes along the polynucleotide. The detection of a conformational change may be carried out by measuring changes in a fluorophore bound to the enzyme.
    Type: Application
    Filed: May 4, 2012
    Publication date: August 23, 2012
    Applicant: GEN-PROBE INCORPORATED
    Inventor: Daniel Henry DENSHAM
  • DNA SEQUENCING METHOD
    Publication number: 20110177520
    Abstract: A method for determining the sequence of a polynucleotide, the method relying on the detection of a conformational change in an enzyme that interacts with and processes along the polynucleotide. The detection of a conformational change may be carried out by measuring changes in a fluorophore bound to the enzyme.
    Type: Application
    Filed: March 29, 2011
    Publication date: July 21, 2011
    Inventor: Daniel Henry DENSHAM
  • DNA sequencing method
    Patent number: 7939264
    Abstract: The present invention pertains to a method for determining the sequence of a polynucleotide, the method relying on the detection of a conformational change in an enzyme that interacts with and processes along the polynucleotide. The detection of a conformational change may be carried out by measuring changes in a fluorophore bound to the enzyme.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: May 10, 2011
    Assignee: Gen-Probe Incorporated
    Inventor: Daniel Henry Densham
  • Nucleic Acid Sequence Analysis
    Publication number: 20100316999
    Abstract: The present invention relates to a method for determining the sequence of a polynucleotide, the method comprising the steps of: (i) reacting a target polynucleotide with a polymerase enzyme immobilised on a solid support, and the different nucleotides, under conditions sufficient for the polymerase reaction; and (ii) detecting the incorporation of a specific nucleotide complementary to the target polynucleotide, by measuring radiation.
    Type: Application
    Filed: January 4, 2010
    Publication date: December 16, 2010
    Inventor: Daniel Henry Densham
  • Method for determining biophysical properties
    Patent number: 7608397
    Abstract: The invention is a method for detecting a change in the conformational or energetic state of a molecular species, comprising the steps of: (i) immobilizing the molecular species, under conditions suitable for the reaction to occur; (ii) contacting at least part of the molecular species with a localized electromagnetic field; and (iii) detecting a change in dielectric constant during or after the reaction, to thereby detect a change in the conformational or energetic state of the molecular species.
    Type: Grant
    Filed: June 13, 2005
    Date of Patent: October 27, 2009
    Assignee: Medical Biosystems Ltd
    Inventor: Daniel Henry Densham
  • Polynucleotide Sequencing Method
    Publication number: 20090029383
    Abstract: The subject invention pertains to a method for determining the sequence of a polynucleotide comprising the steps of (i) contacting a polynucleotide processive enzyme immobilised in a fixed position, with a target polynucleotide under conditions sufficient to induce enzyme activity; (ii) detecting an effect consequent on the interaction of the enzyme and polynucleotide, wherein the effect is detected by measurement of a non-linear optical signal or a linear signal coupled to a non-linear signal.
    Type: Application
    Filed: September 8, 2008
    Publication date: January 29, 2009
    Inventor: Daniel Henry Densham
  • Nucleic acid sequence analysis
    Patent number: 7008766
    Abstract: The present invention relates to a method for determining the sequence of a polynucleotide, the method comprising the steps of: (i) reacting a target polynucleotide with a polymerase enzyme immobilised on a solid support, and the different nucleotides, under conditions sufficient for the polymerase reaction; and (ii) detecting the incorporation of a specific nucleotide complementary to the target polynucleotide, by measuring radiation.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: March 7, 2006
    Assignee: Medical Biosystems, Ltd.
    Inventor: Daniel Henry Densham
  • DNA sequencing method
    Patent number: 6908736
    Abstract: The present invention pertains to a method for determining the sequence of a polynucleotide, the method relying on the detection of a conformational change in an enzyme that interacts with and processes along the polynucleotide. The detection of a conformational change may be carried out by measuring changes in a fluorophore bound to the enzyme.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: June 21, 2005
    Assignee: Medical Biosystems, Ltd.
    Inventor: Daniel Henry Densham
  • Polynucleotide sequencing method
    Publication number: 20040241678
    Abstract: The subject invention pertains to a method for determining the sequence of a polynucleotide comprising the steps of (i) contacting a polynucleotide processive enzyme immobilised in a fixed position, with a target polynucleotide under conditions sufficient to induce enzyme activity; (ii) detecting an effect consequent on the interaction of the enzyme and polynucleotide, wherein the effect is detected by measurement of a non-linear optical signal or a linear signal coupled to a non-linear signal.
    Type: Application
    Filed: November 17, 2003
    Publication date: December 2, 2004
    Inventor: Daniel Henry Densham
  • Nucleic acid sequence analysis
    Publication number: 20040241719
    Abstract: The present invention relates to a method for determining the sequence of a polynucleotide, the method comprising the steps of: (i) reacting a target polynucleotide with a polymerase enzyme immobilised on a solid support, and the different nucleotides, under conditions sufficient for the polymerase reaction; and (ii) detecting the incorporation of a specific nucleotide complementary to the target polynucleotide, by measuring radiation.
    Type: Application
    Filed: February 24, 2004
    Publication date: December 2, 2004
    Inventor: Daniel Henry Densham
  • Polynucleotide synthesis using a processing enzyme
    Patent number: 6623929
    Abstract: The present invention pertains to a method for polynucleotide synthesis, comprising the steps of: (i) reacting a polynucleotide processive enzyme, e.g., a polymerase or TdT, with a nucleotide substrate under conditions suitable for enzyme activity; and (ii) modulating the conformation of the enzyme, e.g. using radiation, to allow incorporation of a predetermined nucleotide.
    Type: Grant
    Filed: January 2, 2002
    Date of Patent: September 23, 2003
    Assignee: Medical Biosystems, Ltd.
    Inventor: Daniel Henry Densham