Patents by Inventor Daniel R. Boggs

Daniel R. Boggs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210282684
    Abstract: A plasmapheresis system and a method for operating a plasmapheresis system are provided by which a volume of plasma product (i.e., anticoagulated plasma) so that that the targeted volume of pure plasma in the plasma product is determined based on donor-specific characteristics. In particular, the targeted amount of pure plasma to be collected is based on the weight, or the weight and the height, of the donor. The targeted volume of pure plasma to be collected, TVP, may be a multiple of the donor's weight. Alternatively, TVP may be a multiple of the donor's total blood volume, TBV, with the TBV of the donor being determined based on the donor's weight and height. A target volume for the plasma product to be collected, TVPP, is established, and separation of whole blood into a plasma component and a second component continues until the volume of plasma product in a collection container equals TVPP.
    Type: Application
    Filed: May 3, 2021
    Publication date: September 16, 2021
    Inventors: Amit J. Patel, Samantha M. Planas, Walter T. Watts, Kyungyoon Min, Daniel R. Boggs, Katherine N. Radwanski
  • Patent number: 11110216
    Abstract: A plasmapheresis system and a method for operating a plasmapheresis system are provided by which the volume/weight of anticoagulated plasma that is collected is optimized. In one example, a nomogram is provided that utilizes the donor's hematocrit to calculate the volume/weight of raw plasma within a plasma product having the maximum volume permitted by the FDA nomogram. In a plasmapheresis procedure having multiple collection phases followed by a reinfusion cycle in which concentrated red blood cells are returned to the donor, the volume of plasma product to be collected is calculated prior to the start of each collection cycle to account for the donor's increasing hematocrit, thus resulting in a greater total volume of plasma product to be collected during the plasmapheresis procedure.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: September 7, 2021
    Assignee: Fenwal, Inc.
    Inventors: Amit J. Patel, Samantha M. Planas, Walter T. Watts, Kyungyoon Min, Daniel R. Boggs
  • Patent number: 11097042
    Abstract: A plasmapheresis system and a method for operating a plasmapheresis system are provided by which the volume/weight of anticoagulated plasma that is collected is optimized. In one example, a nomogram is provided that utilizes the donor's hematocrit to calculate the volume/weight of raw plasma within a plasma product having the maximum volume permitted by the FDA nomogram. In a plasmapheresis procedure having multiple collection phases followed by a reinfusion cycle in which concentrated red blood cells are returned to the donor, the volume of plasma product to be collected is calculated prior to the start of each collection cycle to account for the donor's increasing hematocrit, thus resulting in a greater total volume of plasma product to be collected during the plasmapheresis procedure.
    Type: Grant
    Filed: March 8, 2021
    Date of Patent: August 24, 2021
    Assignee: Fenwal, Inc.
    Inventors: Amit J. Patel, Samantha M. Planas, Walter T. Watts, Kyungyoon Min, Daniel R. Boggs
  • Publication number: 20210187182
    Abstract: A plasmapheresis system and a method for operating a plasmapheresis system are provided by which the volume/weight of anticoagulated plasma that is collected is optimized. In one example, a nomogram is provided that utilizes the donor's hematocrit to calculate the volume/weight of raw plasma within a plasma product having the maximum volume permitted by the FDA nomogram. In a plasmapheresis procedure having multiple collection phases followed by a reinfusion cycle in which concentrated red blood cells are returned to the donor, the volume of plasma product to be collected is calculated prior to the start of each collection cycle to account for the donor's increasing hematocrit, thus resulting in a greater total volume of plasma product to be collected during the plasmapheresis procedure.
    Type: Application
    Filed: March 8, 2021
    Publication date: June 24, 2021
    Inventors: Amit J. Patel, Samantha M. Planas, Walter T. Watts, Kyungyoon Min, Daniel R. Boggs
  • Patent number: 10946131
    Abstract: A plasmapheresis system and a method for operating a plasmapheresis system are provided by which the volume/weight of anticoagulated plasma that is collected is optimized. In one example, a nomogram is provided that utilizes the donor's hematocrit to calculate the volume/weight of raw plasma within a plasma product having the maximum volume permitted by the FDA nomogram. In a plasmapheresis procedure having multiple collection phases followed by a reinfusion cycle in which concentrated red blood cells are returned to the donor, the volume of plasma product to be collected is calculated prior to the start of each collection cycle to account for the donor's increasing hematocrit, thus resulting in a greater total volume of plasma product to be collected during the plasmapheresis procedure.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: March 16, 2021
    Assignee: Fenwal, Inc.
    Inventors: Amit J. Patel, Samantha M. Planas, Walter T. Watts, Kyungyoon Min, Daniel R. Boggs
  • Publication number: 20210043316
    Abstract: A system and method for collecting plasma includes drawing whole blood from a donor, combining anticoagulant with the whole blood from the donor, separating the whole blood into a plasma product and a second blood component and sending the plasma product to a collection container. A controller receives parameters over a network from a remote computer, receives a user input to confirm the a parameter and/or procedure, determines a target volume for plasma product and/or raw plasma based on the parameters and, in response to confirming the donor, controls the system to collect the plasma using draw and return phases.
    Type: Application
    Filed: October 23, 2020
    Publication date: February 11, 2021
    Inventors: Brian C. Case, Lan T. Nguyen, Amit J. Patel, Samantha M. Planas, Walter T. Watts, Kyungyoon Min, Daniel R. Boggs
  • Publication number: 20210015989
    Abstract: A plasmapheresis system and a method for operating a plasmapheresis system are provided by which the volume/weight of anticoagulated plasma that is collected is optimized. In one example, a nomogram is provided that utilizes the donor's hematocrit to calculate the volume/weight of raw plasma within a plasma product having the maximum volume permitted by the FDA nomogram. In a plasmapheresis procedure having multiple collection phases followed by a reinfusion cycle in which concentrated red blood cells are returned to the donor, the volume of plasma product to be collected is calculated prior to the start of each collection cycle to account for the donor's increasing hematocrit, thus resulting in a greater total volume of plasma product to be collected during the plasmapheresis procedure.
    Type: Application
    Filed: October 2, 2020
    Publication date: January 21, 2021
    Inventors: Amit J. Patel, Samantha M. Planas, Walter T. Watts, Kyungyoon Min, Daniel R. Boggs
  • Publication number: 20210008272
    Abstract: A plasmapheresis system and a method for operating a plasmapheresis system are provided by which the volume/weight of anticoagulated plasma that is collected is optimized. In one example, a nomogram is provided that utilizes the donor's hematocrit to calculate the volume/weight of raw plasma within a plasma product having the maximum volume permitted by the FDA nomogram. In a plasmapheresis procedure having multiple collection phases followed by a reinfusion cycle in which concentrated red blood cells are returned to the donor, the volume of plasma product to be collected is calculated prior to the start of each collection cycle to account for the donor's increasing hematocrit, thus resulting in a greater total volume of plasma product to be collected during the plasmapheresis procedure.
    Type: Application
    Filed: May 21, 2019
    Publication date: January 14, 2021
    Inventors: Amit J. Patel, Samantha M. Planas, Walter T. Watts, Kyungyoon Min, Daniel R. Boggs
  • Publication number: 20200147289
    Abstract: A plasmapheresis system and a method for operating a plasmapheresis system are provided by which the volume/weight of anticoagulated plasma that is collected is optimized. In one example, a nomogram is provided that utilizes the donor's hematocrit to calculate the volume/weight of raw plasma within a plasma product having the maximum volume permitted by the FDA nomogram. In a plasmapheresis procedure having multiple collection phases followed by a reinfusion cycle in which concentrated red blood cells are returned to the donor, the volume of plasma product to be collected is calculated prior to the start of each collection cycle to account for the donor's increasing hematocrit, thus resulting in a greater total volume of plasma product to be collected during the plasmapheresis procedure.
    Type: Application
    Filed: January 10, 2020
    Publication date: May 14, 2020
    Inventors: Amit J. Patel, Samantha M. Planas, Walter T. Watts, Kyungyoon Min, Daniel R. Boggs
  • Patent number: 10400216
    Abstract: Systems and methods for the washing of biological fluid/biological cells are disclosed. The method provides for the automated dilution of the cell feed during the cell washing procedure using a separator in which the separator has a predetermined maximum output concentration for the biological cells that are being washed. The method further includes determining the concentration ratio of the biological cells to be washed in the washing procedure and determining a maximum input concentration as a function of the maximum output concentration and the concentration ratio. Wash solution is then added to dilute said biological cells so that the maximum input concentration of the diluted biological cells entering the separator is not exceeded.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: September 3, 2019
    Assignee: Fenwal, Inc.
    Inventors: Christopher J. Wegener, Daniel R. Boggs, Bret M. Olson
  • Patent number: 10300189
    Abstract: A system and method are provided for controlling fouling and complement protein activation during separation of plasma from whole blood using a spinning membrane separator. The separator includes a pair of relatively rotating surfaces spaced apart to define a gap therebetween, with at least one of the surfaces comprising a membrane that allows plasma to pass therethrough but substantially prevents the passage of red cells. In accordance with the method, the membrane material and membrane fabrication technique are selected so as that the resulting membrane both resists fouling and complement protein activation. In a specific embodiment, the membrane is has a smooth surface and substantially linear pores. The pores have a nominal diameter of less than 2 microns (so as to exclude platelets) and preferably a diameter of from 0.6 microns to 0.8 microns, as may be obtained by use of track-etching.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: May 28, 2019
    Assignee: Fenwal, Inc.
    Inventors: Benjamin E. Kusters, Kyungyoon Min, Christopher J. Wegener, Daniel R. Boggs
  • Publication number: 20180303997
    Abstract: A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
    Type: Application
    Filed: July 2, 2018
    Publication date: October 25, 2018
    Inventors: Benjamin E. Kusters, Christopher J. Wegener, Daniel R. Boggs, Kyungyoon Min, William H. Cork, Daryl R. Calhoun, Bryan Blickman, Daniel Lynn
  • Patent number: 9962478
    Abstract: Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: May 8, 2018
    Assignee: Fenwal, Inc.
    Inventors: Daniel R. Boggs, Kyungyoon Min, Lan T. Nguyen, John T. Foley, Brian C. Case
  • Patent number: 9656013
    Abstract: A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: May 23, 2017
    Assignee: Fenwal, Inc.
    Inventors: Benjamin E. Kusters, Christopher J. Wegener, Daniel R. Boggs, Kyungyoon Min
  • Publication number: 20170128656
    Abstract: A system and method are provided for controlling fouling and complement protein activation during separation of plasma from whole blood using a spinning membrane separator. The separator includes a pair of relatively rotating surfaces spaced apart to define a gap therebetween, with at least one of the surfaces comprising a membrane that allows plasma to pass therethrough but substantially prevents the passage of red cells. In accordance with the method, the membrane material and membrane fabrication technique are selected so as that the resulting membrane both resists fouling and complement protein activation. In a specific embodiment, the membrane is has a smooth surface and substantially linear pores. The pores have a nominal diameter of less than 2 microns (so as to exclude platelets) and preferably a diameter of from 0.6 microns to 0.8 microns, as may be obtained by use of track-etching.
    Type: Application
    Filed: April 30, 2014
    Publication date: May 11, 2017
    Inventors: Benjamin E. Kusters, Kyungyoon Min, Christopher J. Wegener, Daniel R. Boggs
  • Publication number: 20160296688
    Abstract: Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.
    Type: Application
    Filed: June 16, 2016
    Publication date: October 13, 2016
    Inventors: Daniel R. Boggs, Kyungyoon Min, Lan T. Nguyen, John T. Foley, Brian C. Case
  • Patent number: 9408961
    Abstract: A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: August 9, 2016
    Assignee: Fenwal, Inc.
    Inventors: Christopher J. Wegener, Kyungyoon Min, Laurent Forcioli, Mark J. Brierton, Daniel R. Boggs
  • Patent number: 9399113
    Abstract: A method is provided for making a tubing, which includes forming a generally tubular inner layer by flowing a first material through an extrusion assembly. At least one non-tubular segment is formed along the length of the tubing by flowing a second material through the extrusion assembly. A generally tubular outer layer coaxial with the inner layer is formed by flowing a third material through the extrusion assembly. The segment is positioned between the inner and outer layers and oriented non-tangentially with an interface between the inner and outer layers. The resulting tubing, which may be suitable for medical applications, may have kink-resistant properties.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: July 26, 2016
    Assignee: Fenwal, Inc.
    Inventors: Craig Sandford, Dean R. Marshall, Daniel R. Boggs, Alvin Peralta-Faulkner, Daryl Calhoun
  • Patent number: 9393359
    Abstract: Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 19, 2016
    Assignee: Fenwal, Inc.
    Inventors: Daniel R. Boggs, Kyungyoon Min, Lan T. Nguyen, John T. Foley, Brian Case
  • Patent number: 9381291
    Abstract: A membrane separation device for use in blood processing procedures is disclosed. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: July 5, 2016
    Assignee: Fenwal, Inc.
    Inventors: Daniel R. Boggs, Mark J. Brierton, Benjamin E. Kusters, Kyungyoon Min, Christopher J. Wegener