Patents by Inventor Daniel Santi

Daniel Santi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20020137152
    Abstract: Desoxyepothilone compounds are produced by fermentation of an epothilone producing microorganism in the presence of a P450 enzyme inhibitor.
    Type: Application
    Filed: July 25, 2001
    Publication date: September 26, 2002
    Inventors: Daniel Santi, Brian Metcalf, Gary Ashley
  • Publication number: 20020094962
    Abstract: The present invention provides novel macrolide compounds of the formulas 1
    Type: Application
    Filed: November 21, 2001
    Publication date: July 18, 2002
    Inventors: Gary Ashley, Brian Metcalf, Zong-Qiang Tian, Daniel Santi
  • Publication number: 20020065295
    Abstract: The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods fort their use.
    Type: Application
    Filed: May 10, 2001
    Publication date: May 30, 2002
    Inventors: Daniel Chu, Maria Fardis, Chaitan Khosla, Christopher Reeves, Daniel Santi, Andreas Schirmer
  • Publication number: 20020052028
    Abstract: The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKS”) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediates”) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers.
    Type: Application
    Filed: August 9, 2001
    Publication date: May 2, 2002
    Inventors: Daniel Santi, Gary Ashley, David C. Myles
  • Publication number: 20020045609
    Abstract: The present invention relates to 16-membered macrocyclic compounds. These compounds are cytotoxic agents and can be used to treat cancer and non-cancer disorders characterized by cellular hyperproliferation.
    Type: Application
    Filed: May 15, 2001
    Publication date: April 18, 2002
    Inventors: Gary Ashley, Maria Fardis, Daniel Santi
  • Publication number: 20020025936
    Abstract: The present invention provides novel macrolide compounds of the formulas 1
    Type: Application
    Filed: February 15, 2001
    Publication date: February 28, 2002
    Inventors: Gary Ashley, Mark Burlingame, Christopher Carreras, Daniel Santi
  • Publication number: 20020010328
    Abstract: Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.
    Type: Application
    Filed: April 3, 2001
    Publication date: January 24, 2002
    Inventors: Christopher Reeves, Daniel Chu, Chaitan Khosla, Daniel Santi, Kai Wu
  • Publication number: 20020004229
    Abstract: Generic overproduction host cells can be used to produce any polyketide and obviate the need for performing conventional strain improvement.
    Type: Application
    Filed: May 1, 2001
    Publication date: January 10, 2002
    Inventors: Daniel Santi, Robert McDaniel, Li Tang, Chaitan Khosla