Patents by Inventor Daniel Van Der Lelie

Daniel Van Der Lelie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240096440
    Abstract: Methods are provided for the rational design of stable communities of microbes for benefiting the health of a host organism, including human and/or animal health. The methods describe design of microbial consortia based on providing and/or complementing key functionalities lacking or underrepresented in the microbiome of an organism having a disorder or disease as compared to healthy subjects. The consortia are designed to possess metabolic interdependencies for improved engrafting, stability and performance of the consortium. Compositions that include the designed microbial consortia are provided for treatment of disorders/diseases involving chronic inflammation, infection, and the combination of chronic inflammation and infection including inflammatory bowel disease and related disorders. The compositions are also broadly applicable for the treatment of neurological, metabolic and oncology-related conditions.
    Type: Application
    Filed: September 13, 2023
    Publication date: March 21, 2024
    Inventors: Daniel van der Lelie, Safiyh Taghavi
  • Publication number: 20230381247
    Abstract: Compositions containing live cultures of 11 separately isolated bacterial strains (the bacterial consortium containing all 11 strains designated GUT-108) are provided for treating conditions of systemic inflammation including, to name a few, Inflammatory Bowel Diseases, type-2 diabetes, metabolic syndrome and obesity, and aging-related conditions of chronic inflammation. In a mouse model of chronic immune-mediated colitis, therapeutic application of GUT-108 reversed the established inflammation in the cecum. In addition, the treatment with GUT-108 unexpectedly resulted in restoration of a healthy gut microbiome in the mice containing an abundance of beneficial Clostridium strains not part of GUT-108, and a decrease in abundance of the applied pathogenic Enterobacteriaceae bacteria from 5% to below 0.5%.
    Type: Application
    Filed: October 14, 2021
    Publication date: November 30, 2023
    Inventors: Daniel van der Lelie, Safiyh Taghavi
  • Patent number: 11810650
    Abstract: Methods are provided for the rational design of stable communities of microbes for benefiting the health of a host organism, including human and/or animal health. The methods describe design of microbial consortia based on providing and/or complementing key functionalities lacking or underrepresented in the microbiome of an organism having a disorder or disease as compared to healthy subjects. The consortia are designed to possess metabolic interdependencies for improved engrafting, stability and performance of the consortium. Compositions that include the designed microbial consortia are provided for treatment of disorders/diseases involving chronic inflammation, infection, and the combination of chronic inflammation and infection including inflammatory bowel disease and related disorders. The compositions are also broadly applicable for the treatment of neurological, metabolic and oncology-related conditions.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: November 7, 2023
    Assignee: Gusto Global, LLC
    Inventors: Daniel van der Lelie, Safiyh Taghavi
  • Publication number: 20230077291
    Abstract: The present application discloses method of controlling plant pathogen(s), e.g. fungal and bacterial pathogens, on a plant, wherein a composition comprising Bacillus amyloliquefaciens FCC1256 deposited as ATCC No. PTA-122162 is applied to the plant, in particular to over-ground parts of the plant. The composition may comprise iturin and fengycin in a relative weight ratio of 1.3:1.0 to 3.0:1.0. The application also discloses an agricultural composition comprising the novel strain, a carrier, a surface-active agent and optionally a buffer, and a corresponding concentrate.
    Type: Application
    Filed: November 16, 2022
    Publication date: March 9, 2023
    Applicant: FMC Corporation
    Inventors: Daniel Van Der Lelie, Safiyh Taghavi, Anthony Andrew Devine, Jaeheon Lee
  • Patent number: 11528910
    Abstract: Methods of controlling a plant pathogen, e.g. fungal and bacterial pathogens, on a plant, are described wherein an agricultural composition comprising Bacillus amyloliquefaciens FCC1256 deposited as ATCC No. PTA-122162, a carrier, a surface-active agent and optionally a buffer, and a corresponding concentrate is also described.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: December 20, 2022
    Assignee: FMC Corporation
    Inventors: Daniel Van Der Lelie, Safiyh Taghavi, Anthony Andrew Devine, Jaeheon Lee
  • Patent number: 10645934
    Abstract: The present invention relates to a novel species of Enterobacter, Enterobacter sp. 638, and to its use in connection, for example, with a method for increasing growth in a plant, increasing biomass in a plant, increasing fruit and/or seed productivity in a plant, increasing disease tolerance and/or resistance in a plant, and increasing drought tolerance and/or resistance in a plant, as compared to a control or wild-type plant grown under identical conditions without application of the inventive method or composition. The methods include applying an effective amount of a composition, which includes an isolated culture of Enterobacter sp. 638, to the plant.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: May 12, 2020
    Assignee: BROOKHAVEN SCIENCE ASSOCIATES/BROOKHAVEN NATIONAL LABORATORY
    Inventors: Lee Newman, Daniel van der Lelie, Safiyh Taghavi
  • Publication number: 20200100504
    Abstract: The present application discloses method of controlling plant pathogen(s), e.g. fungal and bacterial pathogens, on a plant, wherein a composition comprising Bacillus amyloliquefaciens FCC1256 deposited as ATCC No. PTA-122162 is applied to the plant, in particular to over-ground parts of the plant. The composition may comprise iturin and fengycin in a relative weight ratio of 1.3:1.0 to 3.0:1.0. The application also discloses an agricultural composition comprising the novel strain, a carrier, a surface-active agent and optionally a buffer, and a corresponding concentrate.
    Type: Application
    Filed: September 27, 2019
    Publication date: April 2, 2020
    Inventors: Daniel Van Der Lelie, Safiyh Taghavi, Anthony Andrew Devine, Jaeheon Lee
  • Publication number: 20200027524
    Abstract: Methods are provided for the rational design of stable communities of microbes for benefiting the health of a host organism, including human and/or animal health. The methods describe design of microbial consortia based on providing and/or complementing key functionalities lacking or underrepresented in the microbiome of an organism having a disorder or disease as compared to healthy subjects. The consortia are designed to possess metabolic interdependencies for improved engrafting, stability and performance of the consortium. Compositions that include the designed microbial consortia are provided for treatment of disorders/diseases involving chronic inflammation, infection, and the combination of chronic inflammation and infection including inflammatory bowel disease and related disorders. The compositions are also broadly applicable for the treatment of neurological, metabolic and oncology-related conditions.
    Type: Application
    Filed: October 3, 2019
    Publication date: January 23, 2020
    Inventors: Daniel van der Lelie, Safiyh Taghavi
  • Publication number: 20200016256
    Abstract: Provided herein are compositions (e.g., probiotic, pharmaceutical, etc.) comprising one or more strains of non-Clostridia class bacteria and methods of use thereof for allergen desensitization. In particular, bacteria of bacterial classes such as Negativicutes, Actinobacteria, and Bacteroidia support allergen desensitization, for example, by promoting production of metabolites that aid in desensitization or performing catabolism of food allergens.
    Type: Application
    Filed: September 22, 2017
    Publication date: January 16, 2020
    Applicants: The University of Chicago, Gusto Global, LLC
    Inventors: Jack A. GILBERT, Daniel van der LELIE, Safiyh TAGHAVI
  • Patent number: 10390535
    Abstract: Compositions are provided that include a new Bacillus thuringiensis strain designated RTI545 for use in benefiting plant growth and controlling plant pests. In particular, the RTI545 strain is useful for controlling plant nematode, insect and fungal pests. The compositions include plant seeds coated with the RTI545 strain. The compositions can be applied alone or in combination with other microbial, biological, or chemical insecticides, fungicides, nematicides, bacteriocides, herbicides, plant extracts, plant growth regulators, or fertilizers. In one example, enhanced growth and insect control are provided by delivering at the time of planting a combination of a chemical insecticide such as bifenthrin and a liquid fertilizer to plants or seeds treated with RTI545.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: August 27, 2019
    Assignee: FMC Corporation
    Inventors: Daniel Van Der Lelie, Safiyh Taghavi, Vincent J. Spadafora, Sylwia L. Fudali-Alves, Nathan Caldwell, Matthew F. Pye, Anders Obel, Robert B. Albright, Guozhi Wang, Chelsea E. Tirrell, Gorm V. Petersen, Jaeheon Lee, Anthony Devine, Roderick G. McLeod, Kevin Brost, John E. Kibbee
  • Patent number: 10375964
    Abstract: Compositions and methods are provided for a combination of a new strain of Bacillus amyloliquefaciens RTI301 and a new strain of Bacillus subtilis RTI477, the combination having growth promoting activity and activity against plant pathogens. The compositions containing the RTI301 and RTI477 strains are useful for benefiting plant growth and/or conferring protection against a pathogenic infection when applied to plant roots, seeds, callus tissue, grafts, and cuttings. Synergistic results are observed for the combination of the strains, and the combination of strains is useful to increase yield in crops including soybean and corn. The compositions containing the combination of strains can be applied alone or in combination with other microbial, biological, or chemical insecticides, fungicides, nematicides, bacteriocides, herbicides, plant extracts, plant growth regulators, and fertilizers.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: August 13, 2019
    Assignee: FMC Corporation
    Inventors: Safiyh Taghavi, Daniel van der Lelie, Roderick McLeod, Kevin R. Brost, John E. Kibbee
  • Publication number: 20190216091
    Abstract: Compositions and methods for application to plants are provided for a new strain of Bacillus licheniformis RTI184 having plant growth promoting activity. Compositions and extracts of Bacillus licheniformis strains that include newly identified Fengycin-like and Dehydroxyfengycin-like cyclic lipopeptides designated as “Fengycin MB-Cit” and “Dehydroxyfengycin MB-Cit”, respectively, are also provided. In particular aspects, compositions containing the Bacillus licheniformis strain RTI184 can be applied alone or in combination with chemical agents or other microbial agents to benefit plant growth.
    Type: Application
    Filed: March 27, 2019
    Publication date: July 18, 2019
    Inventors: Safiyh Taghavi, Daniel Van Der Lelie, Jaeheon Lee
  • Publication number: 20190191707
    Abstract: Compositions and methods include a combination of a strain of Bacillus licheniformis CH200 and a strain of Bacillus subtilis CH201 for delivery to plants and plant seeds, the combination having activity against plant fungal pathogens. In particular, the combination of strains is useful for increasing yield in crops including soybean and corn in the presence of plant pathogens. The Bacillus licheniformis CH200 and Bacillus subtilis CH201 strains can be applied alone or in combination with other microbial, biological, or chemical insecticides, fungicides, nematicides, bacteriocides, herbicides, plant extracts, plant growth regulators, and fertilizers.
    Type: Application
    Filed: August 30, 2017
    Publication date: June 27, 2019
    Inventors: Safiyh Taghavi, Daniel Van Der Lelie, Jaeheon Lee, Roderick Mcleod, John E. Kibbee, Kevin R. Brost, Guozhi Wang, Vincent J. Spadafora, Matthew F. Pye
  • Publication number: 20180195138
    Abstract: Compositions and methods include a new strain of Bacillus amyloliquefaciens having growth promoting activity and activity against plant pathogens. The compositions are useful for benefiting plant growth and/or conferring protection against a pathogenic infection when applied to plant foliage, flowers, fruits, bark, roots, seeds, callus tissue, grafts, cuttings, surrounding soil or growth medium, and soil or growth medium concomitant with sowing seed and planting callus tissue, grafts, and cuttings. The compositions containing the Bacillus amyloliquefaciens RTI301 strain can be applied alone or in combination with other microbial, biological, or chemical insecticides, fungicides, nematicides, bacteriocides, herbicides, plant extracts, plant growth regulators, and fertilizers.
    Type: Application
    Filed: January 8, 2018
    Publication date: July 12, 2018
    Inventors: Safiyh Taghavi, Daniel Van Der Lelie, Jaeheon Lee
  • Publication number: 20180092363
    Abstract: Compositions are provided that include a new Bacillus thuringiensis strain designated RTI545 for use in benefiting plant growth and controlling plant pests. In particular, the RTI545 strain is useful for controlling plant nematode, insect and fungal pests. The compositions include plant seeds coated with the RTI545 strain. The compositions can be applied alone or in combination with other microbial, biological, or chemical insecticides, fungicides, nematicides, bacteriocides, herbicides, plant extracts, plant growth regulators, or fertilizers. In one example, enhanced growth and insect control are provided by delivering at the time of planting a combination of a chemical insecticide such as bifenthrin and a liquid fertilizer to plants or seeds treated with RTI545.
    Type: Application
    Filed: October 5, 2017
    Publication date: April 5, 2018
    Inventors: Daniel Van Der Lelie, Safiyh Taghavi, Vincent J. Spadafora, Sylwia L. Fudali-Alves, Nathan Caldwell, Matthew F. Pye, Anders Obel, Robert B. Albright, Guozhi Wang, Chelsea E. Tirrell, Gorm V. Petersen, Jaeheon Lee, Anthony Devine, Roderick G. McLeod
  • Publication number: 20180020676
    Abstract: Compositions and methods include a new strain of Bacillus velezensis having growth promoting activity and activity against plant pathogens. The compositions are useful for benefiting plant growth and/or conferring protection against a pathogenic infection when applied to plant foliage, flowers, fruits, bark, roots, seeds, callus tissue, grafts, cuttings, surrounding soil or growth medium, and soil or growth medium concomitant with sowing seed and planting callus tissue, grafts, and cuttings. The compositions containing the Bacillus velezensis RTI301 strain can be applied alone or in combination with other microbial, biological, or chemical insecticides, fungicides, nematicides, bacteriocides, herbicides, plant extracts, plant growth regulators, and fertilizers.
    Type: Application
    Filed: October 6, 2017
    Publication date: January 25, 2018
    Inventors: Safiyh Taghavi, Daniel Van Der Lelie, Jaeheon Lee, Anthony Devine
  • Publication number: 20170367347
    Abstract: Compositions and methods are provided for a combination of a new strain of Bacillus amyloliquefaciens RTI301 and a new strain of Bacillus subtilis RTI477, the combination having growth promoting activity and activity against plant pathogens. The compositions containing the RTI301 and RTI477 strains are useful for benefiting plant growth and/or conferring protection against a pathogenic infection when applied to plant roots, seeds, callus tissue, grafts, and cuttings. Synergistic results are observed for the combination of the strains, and the combination of strains is useful to increase yield in crops including soybean and corn. The compositions containing the combination of strains can be applied alone or in combination with other microbial, biological, or chemical insecticides, fungicides, nematicides, bacteriocides, herbicides, plant extracts, plant growth regulators, and fertilizers.
    Type: Application
    Filed: December 28, 2015
    Publication date: December 28, 2017
    Inventors: Safiyh Taghavi, Daniel van der Lelie, Roderick McLeod, Kevin R. Brost, John E. Kibbee
  • Publication number: 20170196226
    Abstract: Compositions and methods include a new strain of Bacillus amyloliquefaciens having activity against plant pathogens. The compositions are useful for benefiting plant growth and/or conferring protection against a pathogenic infection when applied to plant foliage, flowers, fruits, bark, roots, seeds, callus tissue, grafts, cuttings, surrounding soil or growth medium, and soil or growth medium concomitant with sowing seed and planting callus tissue, grafts, and cuttings. The compositions containing the Bacillus amyloliquefaciens RTI472 strain can be applied alone or in combination with other microbial, biological, or chemical insecticides, fungicides, nematicides, bacteriocides, herbicides, plant extracts, plant growth regulators, or fertilizers.
    Type: Application
    Filed: March 17, 2017
    Publication date: July 13, 2017
    Inventors: Safiyh Taghavi, Daniel Van Der Lelie, Melanie Ann R. Silinski, Jaeheon Lee
  • Patent number: 9622484
    Abstract: Compositions and methods are provided for a combination of a new strain of Bacillus amyloliquefaciens RTI301 and a new strain of Bacillus subtilis RTI477, the combination having growth promoting activity and activity against plant pathogens. The compositions containing the RTI301 and RTI477 strains are useful for benefiting plant growth and/or conferring protection against a pathogenic infection when applied to plant roots, seeds, callus tissue, grafts, and cuttings. Synergistic results are observed for the combination of the strains, and the combination of strains is useful to increase yield in crops including soybean and corn. The compositions containing the combination of strains can be applied alone or in combination with other microbial, biological, or chemical insecticides, fungicides, nematicides, bacteriocides, herbicides, plant extracts, plant growth regulators, and fertilizers.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: April 18, 2017
    Assignee: FMC Corporation
    Inventors: Safiyh Taghavi, Daniel van der Lelie, Roderick McLeod, Kevin R. Brost, John E. Kibbee
  • Patent number: RE49311
    Abstract: Compositions are provided that include a new Bacillus thuringiensis strain designated RTI545 for use in benefiting plant growth and controlling plant pests. In particular, the RTI545 strain is useful for controlling plant nematode, insect and fungal pests. The compositions include plant seeds coated with the RTI545 strain. The compositions can be applied alone or in combination with other microbial, biological, or chemical insecticides, fungicides, nematicides, bacteriocides, herbicides, plant extracts, plant growth regulators, or fertilizers. In one example, enhanced growth and insect control are provided by delivering at the time of planting a combination of a chemical insecticide such as bifenthrin and a liquid fertilizer to plants or seeds treated with RTI545.
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: November 29, 2022
    Assignee: FMC Corporation
    Inventors: Daniel Van Der Lelie, Safiyh Taghavi, Vincent J. Spadafora, Nathan Caldwell, Anders Obel, Robert B. Albright, Guozhi Wang, Jaeheon Lee, Roderick G. McLeod, Kevin Brost, John E. Kibbee