Patents by Inventor Daniel Van Der Lelie

Daniel Van Der Lelie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130261292
    Abstract: In some embodiments, DNA-capped nanoparticles are used to define a degree of crystalline order in assemblies thereof. In some embodiments, thermodynamically reversible and stable body-centered cubic (bcc) structures, with particles occupying <˜10% of the unit cell, are formed. Designs and pathways amenable to the crystallization of particle assemblies are identified. In some embodiments, a plasmonic crystal is provided. In some aspects, a method for controlling the properties of particle assemblages is provided. In some embodiments a catalyst is formed from nanoparticles linked by nucleic acid sequences and forming an open crystal structure with catalytically active agents attached to the crystal on its surface or in interstices.
    Type: Application
    Filed: June 12, 2013
    Publication date: October 3, 2013
    Inventors: OLEG GANG, DMYTRO NYKYPANCHUK, MATTHEW MAYE, DANIEL VAN DER LELIE
  • Patent number: 8487084
    Abstract: In some embodiments, DNA-capped nanoparticles are used to define a degree of crystalline order in assemblies thereof. In some embodiments, thermodynamically reversible and stable body-centered cubic (bcc) structures, with particles occupying <˜10% of the unit cell, are formed. Designs and pathways amenable to the crystallization of particle assemblies are identified. In some embodiments, a plasmonic crystal is provided. In some aspects, a method for controlling the properties of particle assemblages is provided. In some embodiments a catalyst is formed from nanoparticles linked by nucleic acid sequences and forming an open crystal structure with catalytically active agents attached to the crystal on its surface or in interstices.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: July 16, 2013
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Oleg Gang, Dmytro Nykypanchuk, Mathew Maye, Daniel van der Lelie
  • Publication number: 20130150240
    Abstract: The present invention relates to a novel species of Enterobacter, Enterobacter sp. 638, and to its use in connection, for example, with a method for increasing growth in a plant, increasing biomass in a plant, increasing fruit and/or seed productivity in a plant, increasing disease tolerance and/or resistance in a plant, and increasing drought tolerance and/or resistance in a plant, as compared to a control or wild-type plant grown under identical conditions without application of the inventive method or composition. The methods include applying an effective amount of a composition, which includes an isolated culture of Enterobacter sp. 638, to the plant.
    Type: Application
    Filed: March 10, 2011
    Publication date: June 13, 2013
    Applicant: BROOKHAVEN SCIENCE ASSOCIATES/BROOKHAVEN NATIONAL LABORATORY
    Inventors: Lee Newman, Daniel van der Lelie, Safiyh Taghavi
  • Publication number: 20130137602
    Abstract: The present invention is directed to nanoscale fabrication of nano-materials with application in electronics, energy conversion, bio-sensing and others. Specifically, the invention is directed to arbitrary, that is periodic and non-periodic, assembly of nano-objects on I D and 2D arrays. The present invention utilizes self-organization properties of nanoscale bio-encoded building blocks, programmability of biomolecular interactions, and simple processing techniques for providing arbitrary by-design fabrication capability. Specifically, the present invention utilizes double stranded DNA attached to a surface and intercalating PNA-DNA hybrids attached to nano-objects to bind the nano-objects to the dsDNA in a site specific manner. The present invention allows for an integration of a large number of nano-components in unified well-defined systems.
    Type: Application
    Filed: March 7, 2011
    Publication date: May 30, 2013
    Applicant: Brookhaven Science Associates, LLC
    Inventors: Oleg Gang, Daniel van der Lelie
  • Publication number: 20110196130
    Abstract: The invention relates to the use of peptides, proteins, and other oligomers to provide a means by which normally quenched nanoparticle fluorescence may be recovered upon detection of a target molecule. Further, the inventive technology provides a structure and method to carry out detection of target molecules without the need to label the target molecules before detection. In another aspect, a method for forming arbitrarily shaped two- and three-dimensional protein-mediated nanoparticle structures and the resulting structures are described. Proteins mediating structure formation may themselves be functionalized with a variety of useful moieties, including catalytic functional groups.
    Type: Application
    Filed: June 2, 2009
    Publication date: August 11, 2011
    Applicant: BROOKHAVEN SCIENCE ASSOCIATES
    Inventors: Soo-kwan Lee, Oleg Gang, Daniel van der lelie
  • Publication number: 20090275465
    Abstract: In some embodiments, DNA-capped nanoparticles are used to define a degree of crystalline order in assemblies thereof. In some embodiments, thermodynamically reversible and stable body-centered cubic (bcc) structures, with particles occupying <˜10% of the unit cell, are formed. Designs and pathways amenable to the crystallization of particle assemblies are identified. In some embodiments, a plasmonic crystal is provided. In some aspects, a method for controlling the properties of particle assemblages is provided. In some embodiments a catalyst is formed from nanoparticles linked by nucleic acid sequences and forming an open crystal structure with catalytically active agents attached to the crystal on its surface or in interstices.
    Type: Application
    Filed: April 3, 2009
    Publication date: November 5, 2009
    Applicant: Brookhaven Science Associates, LLC
    Inventors: Oleg Gang, Dmytro Nykypanchuk, Mathew Maye, Daniel van der Lelie
  • Publication number: 20090258355
    Abstract: The present invention is a method of making a nanocluster. The method comprises providing a surface comprising at least one anchoring biomolecule, wherein the surface is in a solution; adding an initial recognition-nano-component to the solution wherein the initial recognition-nano-component comprises i) a nanoparticle and one specifically-bindable-biomolecule, or ii) a nanoparticle and two different types of specifically-bindable-biomolecules, wherein a biomolecule of the initial recognition-nano-component specifically binds to the anchoring biomolecule; and adding a releasing biomolecule to the solution, wherein the releasing biomolecule binds to the anchoring biomolecule with a greater binding strength than the anchoring biomolecule binds to the initial recognition-nano-component, or wherein the releasing biomolecule binds to the initial recognition-nano-component with a greater binding strength than anchoring biomolecule binds to the initial recognition-nano-component, thereby making a nanocluster.
    Type: Application
    Filed: November 3, 2008
    Publication date: October 15, 2009
    Applicant: Brookhaven Science Associates, LLC
    Inventors: Mathew M. Maye, Oleg Gang, Dmytro Nykypanchuk, Daniel van der Lelie
  • Publication number: 20090011511
    Abstract: Disclosed is a method for analyzing the organismic complexity of a sample through analysis of the nucleic acid in the sample. In the disclosed method, through a series of steps, including digestion with a type II restriction enzyme, ligation of capture adapters and linkers and digestion with a type IIS restriction enzyme, genome signature tags are produced. The sequences of a statistically significant number of the signature tags are determined and the sequences are used to identify and quantify the organisms in the sample. Various embodiments of the invention described herein include methods for using single point genome signature tags to analyze the related families present in a sample, methods for analyzing sequences associated with hyper- and hypo-methylated CpG islands, methods for visualizing organismic complexity change in a sampling location over time and methods for generating the genome signature tag profile of a sample of fragmented DNA.
    Type: Application
    Filed: October 26, 2007
    Publication date: January 8, 2009
    Inventors: John J. Dunn, Daniel van der Lelie, Maureen K. Krause, Sean R. McCorkle
  • Patent number: 7323306
    Abstract: Disclosed is a method for analyzing the organismic complexity of a sample through analysis of the nucleic acid in the sample. In the disclosed method, through a series of steps, including digestion with a type II restriction enzyme, ligation of capture adapters and linkers and digestion with a type IIS restriction enzyme, genome signature tags are produced. The sequences of a statistically significant number of the signature tags are determined and the sequences are used to identify and quantify the organisms in the sample. Various embodiments of the invention described herein include methods for using single point genome signature tags to analyze the related families present in a sample, methods for analyzing sequences associated with hyper- and hypo-methylated CpG islands, methods for visualizing organismic complexity change in a sampling location over time and methods for generating the genome signature tag profile of a sample of fragmented DNA.
    Type: Grant
    Filed: March 2, 2004
    Date of Patent: January 29, 2008
    Assignee: Brookhaven Science Associates, LLC
    Inventors: John J Dunn, Daniel van der Lelie, Maureen K. Krause, Sean R. McCorkle
  • Publication number: 20070101461
    Abstract: The invention concerns a method for the phytoremediation treatment of a medium contaminated with at least one element selected from the group consisting of (preferably water soluble and volatile) organic pollutants, heavy metals, radionuclides or a mixture thereof, comprising the step of cultivating upon the contaminated medium a plant associated with an endophytic microorganism able to improve the phytoremediation of the plant, to reduce phytotoxicity of chemicals. The invention further relates to methods for improving phytoremediation by directly modifying members of the endogenous endophytic community of a plant, via horizontal gene transfer. Another part of the invention relates to plants associated with such endophytes and/or plants with a modified endogenous endophytic community.
    Type: Application
    Filed: July 25, 2006
    Publication date: May 3, 2007
    Inventors: Daniel Van Der Lelie, Siegfried D'Haene, David Niall Dowling, Ulrich Karlson, Edward Moore, Safiyh Taghavi, Stefan Trapp, Jaco Vangronsveld
  • Publication number: 20050150003
    Abstract: A method for the phytoremediation treatment of a contaminated medium with at least one element selected from the group consisting of (preferably water soluble and volatile) organic pollutants, heavy metals, radionuclides or a mixture thereof, comprising the step of cultivating upon said contaminated medium a plant associated with an endophytic microorganism able to improve the phytoremediation of said plant, to reduce phytotoxicity of chemicals, and the step of recovering the elements present in said plant.
    Type: Application
    Filed: February 11, 2005
    Publication date: July 7, 2005
    Inventors: Daniel Van Der Lelie, Siegfried D'Haene, David Niall Dowling, Ulrich Karlson, Edward Moore, Safiyh Taghavi, Stefan Trapp, Jaco Vangronsveld
  • Publication number: 20040219580
    Abstract: Disclosed is a method for analyzing the organismic complexity of a sample through analysis of the nucleic acid in the sample. In the disclosed method, through a series of steps, including digestion with a type II restriction enzyme, ligation of capture adapters and linkers and digestion with a type IIS restriction enzyme, genome signature tags are produced. The sequences of a statistically significant number of the signature tags are determined and the sequences are used to identify and quantify the organisms in the sample. Various embodiments of the invention described herein include methods for using single point genome signature tags to analyze the related families present in a sample, methods for analyzing sequences associated with hyper- and hypo-methylated CpG islands, methods for visualizing organismic complexity change in a sampling location over time and methods for generating the genome signature tag profile of a sample of fragmented DNA.
    Type: Application
    Filed: March 2, 2004
    Publication date: November 4, 2004
    Inventors: John J. Dunn, Daniel van der Lelie, Maureen K. Krause, Sean R. McCorkle
  • Publication number: 20030186251
    Abstract: Genomic Signature Tags (GSTs) are the products of a method for identifying and quantitatively analyzing genomic DNAs. The DNA is initially fragmented with a type II restriction enzyme. An oligonucleotide adapter containing a recognition site for MmeI, a type IIS restriction enzyme, is then used to release 21 bp tags from fixed positions in the DNA relative to the sites recognized by the fragmenting enzyme. These tags are PCR-amplified, purified, concatenated into longer molecules, and then cloned and sequenced. The tag sequences and abundances are used to create a GST profile that can identify and quantify the genome of origin within any complex DNA isolate. The total number of GSTs generated from a sample is determined by the incidence of recognition sites for the initial fragmenting enzyme.
    Type: Application
    Filed: April 1, 2002
    Publication date: October 2, 2003
    Applicant: Brookhaven Science Associates, LLC
    Inventors: John J. Dunn, Daniel Van der Lelie, Maureen K. Krause
  • Patent number: 6602666
    Abstract: A recombinant nucleic acid sequence comprising an SOS regulated promoter with an induction ratio higher than 40, said promoter being operatively linked to a reporter encoding nucleic acid sequence encoding a reporter resulting in a signal that can be assayed as light production. A biosensor comprising such a nucleic acid sequence and methods for determining genotoxicity and the presence of multiple genotoxic compounds using such a biosensor are disclosed.
    Type: Grant
    Filed: April 25, 2001
    Date of Patent: August 5, 2003
    Assignee: Vlaamse Instelling Technologisch Onderzoek (V.I.T.O.)
    Inventors: Daniel Van Der Lelie, Brigitte Marie Francoise Borremans, Ann Irma Alice Provoost, Luc Agnes Louis Jean Bosco Regniers, Luc Philipinne Edouard Verschaeve
  • Publication number: 20030126632
    Abstract: A method for the phytoremediation treatment of a contaminated medium with at least one element selected from the group consisting of (preferably water soluble and volatile) organic pollutants, heavy metals, radionuclides or a mixture thereof, comprising the step of cultivating upon said contaminated medium a plant associated with an endophytic microorganism able to improve the phytoremediation of said plant, to reduce phytotoxicity of chemicals, and the step of recovering the elements present in said plant.
    Type: Application
    Filed: May 16, 2002
    Publication date: July 3, 2003
    Inventors: Daniel Van Der Lelie, Siegfried D'Haene, David Niall Dowling, Ulrich Karlson, Edward R.B. Moore, Safiyh Taghavi, Stefan A.J. Trapp, Jaco Vangronsveld
  • Patent number: 6521751
    Abstract: A recombinant nucleic acid sequence comprising an SOS regulated promoter with an induction ratio higher than 40, said promoter being operatively linked to a reporter encoding nucleic acid sequence encoding a reporter resulting in a signal that can be assayed as light production. A biosensor compromising such a nucleic acid sequence and methods for determining genotoxicity and the presence of multiple genotoxic compounds using such a biosensor are disclosed.
    Type: Grant
    Filed: December 2, 1998
    Date of Patent: February 18, 2003
    Assignee: Vlaamse Instelling voor Technologisch Onderzoek (VITO)
    Inventors: Daniel Van Der Lelie, Brigitte Marie Francoise Borremans, Ann Irma Alice Provoost, Luc Agnes Louis Jean Bosco Regniers, Luc Philipinne Edouard Verschaeve
  • Publication number: 20030003578
    Abstract: A recombinant nucleic acid sequence comprising an SOS regulated promoter with an induction ratio higher than 40, said promoter being operatively linked to a reporter encoding nucleic acid sequence encoding a reporter resulting in a signal that can be assayed as light production. A biosensor comprising such a nucleic acid sequence and methods for determining genotoxicity and the presence of multiple genotoxic compounds using such a biosensor are disclosed.
    Type: Application
    Filed: April 25, 2001
    Publication date: January 2, 2003
    Applicant: Vlaamse Instelling Technologisch Onderzoek
    Inventors: Daniel Van Der Lelie, Brigitte Marie Francoise Borremans, Ann Irma Alice Provoost, Luc Agnes Louis Jean Bosco Regniers, Luc Philipinne Edouard Verschaeve
  • Patent number: 6472152
    Abstract: This invention concerns a diagnostic system made of: a transformed microorganism capable of an increased reporter activity upon exposure to an environmental insult, said microorganism having a stress inducible promoter sequence being operatively linked to a reported encoding nucleic acid sequence encoding a reporter molecule resulting in a signal that can be assayed, and of a transformed microorganism having a constitutive and non stress inducible promoter sequence being operatively linked to a reporter encoding nucleic acid sequence encoding a reporter molecule resulting in a signal that can be assayed.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: October 29, 2002
    Assignee: Vlaamse Instelling Voor Technologish Onderzoek (VITO)
    Inventors: Daniel Van Der Lelie, Luc Agnes Louis Jean Bosco Regniers, Safiyh Taghavi, Philippe Gilbert Ghislain Corbisier, Luc Philippine Edouard Verschaeve