Patents by Inventor Darren James Kelly

Darren James Kelly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid forms, salts and polymorphs of anti-fibrotic compounds
    Patent number: 11905231
    Abstract: The present disclosure relates to solid forms and salts, crystalline and otherwise, of (E)-2-[[3-(3-methoxy-4-propargyloxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid and pharmaceutical compositions comprising same. The use of such solid forms, salts, and pharmaceutical compositions, for treating, preventing, or ameliorating diseases or conditions associated with fibrosis, inflammation and/or proliferation are disclosed.
    Type: Grant
    Filed: July 18, 2023
    Date of Patent: February 20, 2024
    Assignee: Certa Therapeutics Pty Ltd
    Inventors: Darren James Kelly, Gareth Rhys Lewis, Lorna Helen Mitchell
  • COMPOUNDS AND METHODS FOR THE TREATMENT OF EYE DISORDERS
    Publication number: 20230270703
    Abstract: Disclosed herein are methods of administration of (E)-2-[[3-methoxy-4- (difluoromethoxy)phenyl-l-oxo-2-propenyl]amino]benzoic acid to a subject, involving particular administration regimes for preventing, treating, reducing the severity of and/or reducing the likelihood of reoccurrence of eye conditions such as diabetic retinopathy and proliferative vitreo-retinopathy. Such eye conditions can have serious consequences, including loss of vision and, in some cases blindness.
    Type: Application
    Filed: June 3, 2021
    Publication date: August 31, 2023
    Inventors: Darren James Kelly, Michelle Papadimitriou, Chris Burns, Eric Daniels
  • Methods of treating eye diseases associated with inflammation and vascular proliferation
    Patent number: 11583535
    Abstract: Methods for treating eye diseases associated with inflammation and/or vascular proliferation in subjects are disclosed. The methods include administering therapeutically effective amounts of a tranilast compound, in particular (E)-2-[[3-(3-Methoxy-4-propargyloxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or (E)-2-[[3,4-Bis(difluoromethoxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or pharmaceutically acceptable salts or solvates thereof.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: February 21, 2023
    Assignee: OCCURX PTY LTD
    Inventors: Darren James Kelly, David Stapleton
  • METHODS OF TREATING EYE DISEASES ASSOCIATED WITH INFLAMMATION AND VASCULAR PROLIFERATION
    Publication number: 20210244741
    Abstract: Methods for treating eye diseases associated with inflammation and/or vascular proliferation in subjects are disclosed. The methods include administering therapeutically effective amounts of a tranilast compound, in particular (E)-2-[[3-(3-Methoxy-4-propargyloxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or (E)-2-[[3,4-Bis(difluoromethoxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or pharmaceutically acceptable salts or solvates thereof.
    Type: Application
    Filed: August 20, 2020
    Publication date: August 12, 2021
    Inventors: Darren James Kelly, David Stapleton
  • Methods of treating eye diseases associated with inflammation and vascular proliferation
    Patent number: 10786510
    Abstract: Methods for treating eye diseases associated with inflammation and/or vascular proliferation in subjects are disclosed. The methods include administering therapeutically effective amounts of a tranilast compound, in particular (E)-2-[[3-(3-Methoxy-4-propargyloxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or (E)-2-[[3,4-Bis(difluoromethoxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or pharmaceutically acceptable salts or solvates thereof.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: September 29, 2020
    Assignee: OccuRX Pty Ltd
    Inventors: Darren James Kelly, David Stapleton
  • Methods of treating eye diseases associated with inflammation and vascular proliferation
    Patent number: 10695353
    Abstract: Methods for treating eye diseases associated with inflammation and/or vascular proliferation in subjects are disclosed. The methods include administering therapeutically effective amounts of a tranilast compound, in particular (E)-2-[[3-(3-Methoxy-4-propargyloxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or (E)-2-[[3,4-Bis(difluoromethoxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or pharmaceutically acceptable salts or solvates thereof.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: June 30, 2020
    Assignee: Occurx Pty Ltd
    Inventors: Darren James Kelly, David Stapleton
  • METHODS OF TREATING EYE DISEASES ASSOCIATED WITH INFLAMMATION AND VASCULAR PROLIFERATION
    Publication number: 20180117051
    Abstract: Methods for treating eye diseases associated with inflammation and/or vascular proliferation in subjects are disclosed. The methods include administering therapeutically effective amounts of a tranilast compound, in particular (E)-2-[[3-(3-Methoxy-4-propargyloxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or (E)-2-[[3,4-Bis(difluoromethoxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or pharmaceutically acceptable salts or solvates thereof.
    Type: Application
    Filed: November 8, 2017
    Publication date: May 3, 2018
    Inventors: Darren James Kelly, David Stapleton
  • METHODS OF TREATING EYE DISEASES ASSOCIATED WITH INFLAMMATION AND VASCULAR PROLIFERATION
    Publication number: 20180117050
    Abstract: Methods for treating eye diseases associated with inflammation and/or vascular proliferation in subjects are disclosed. The methods include administering therapeutically effective amounts of a tranilast compound, in particular (E)-2-[[3-(3-Methoxy-4-propargyloxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or (E)-2-[[3,4-Bis(difluoromethoxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or pharmaceutically acceptable salts or solvates thereof.
    Type: Application
    Filed: November 8, 2017
    Publication date: May 3, 2018
    Inventors: Darren James Kelly, David Stapleton
  • METHODS OF TREATING EYE DISEASES ASSOCIATED WITH INFLAMMATION AND VASCULAR PROLIFERATION
    Publication number: 20180117049
    Abstract: Methods for treating eye diseases associated with inflammation and/or vascular proliferation in subjects are disclosed. The methods include administering therapeutically effective amounts of a tranilast compound, in particular (E)-2-[[3-(3-Methoxy-4-propargyloxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or (E)-2-[[3,4-Bis(difluoromethoxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or pharmaceutically acceptable salts or solvates thereof.
    Type: Application
    Filed: November 8, 2017
    Publication date: May 3, 2018
    Inventors: Darren James Kelly, David Stapleton
  • Fused ring analogues of anti-fibrotic agents
    Patent number: 9951087
    Abstract: The present invention relates to arylcarbonyl and heteroarylcarbonyl anthranilate compounds that may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment disorders.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: April 24, 2018
    Assignee: Fibrotech Therapeutics PTY LTD
    Inventors: Spencer John Williams, Steven Zammit, Darren James Kelly
  • Methods of treating eye diseases associated with inflammation and vascular proliferation
    Patent number: 9839640
    Abstract: Methods for treating eye diseases associated with inflammation and/or vascular proliferation in subjects are disclosed. The methods include administering therapeutically effective amounts of a tranilast compound, in particular (E)-2-[[3-(3-Methoxy-4-propargyloxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or (E)-2-[[3,4-Bis(difluoromethoxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or pharmaceutically acceptable salts or solvates thereof.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: December 12, 2017
    Assignee: OccuRx Pty Ltd
    Inventors: Darren James Kelly, David Stapleton
  • Therapeutic compounds
    Patent number: 9561201
    Abstract: Substituted cinnamoyl anthranilate compounds exhibiting anti-fibrotic activity; or derivatives thereof, analogs thereof, pharmaceutically acceptable salts thereof, and metabolites thereof, with the proviso that the compound is no Tranilast.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: February 7, 2017
    Assignee: Fibrotech Therapeutics PTY LTD
    Inventors: Spencer John Williams, David Stapleton, Steven Zammit, Darren James Kelly, Richard Ernest Gilbert, Henry Krum
  • Fused ring analogues of anti-fibrotic agents
    Patent number: 9062076
    Abstract: The present invention relates to arylcarbonyl and heteroarylcarbonyl anthranilate compounds that may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment disorders.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: June 23, 2015
    Assignee: Fibrotech Therapeutics PTY LTD
    Inventors: Spencer John Williams, Steven Zammit, Darren James Kelly
  • THERAPEUTIC COMPOUNDS
    Publication number: 20140357628
    Abstract: Substituted cinnamoyl anthranilate compounds exhibiting anti-fibrotic activity; or derivatives thereof, analogues thereof, pharmaceutically acceptable salts thereof, and metabolites thereof, with the proviso that the compound is no Tranilast.
    Type: Application
    Filed: June 27, 2014
    Publication date: December 4, 2014
    Applicant: Fibrotech Therapeutics Pty Ltd
    Inventors: Spencer John Williams, David Stapleton, Steven Zammit, Darren James Kelly, Richard Ernest Gilbert, Henry Krum
  • Therapeutic compounds
    Patent number: 8765812
    Abstract: Substituted cinnamoyl anthranilate compounds exhibiting anti-fibrotic activity; or derivatives thereof, analogues thereof, pharmaceutically acceptable salts thereof, and metabolites thereof; with the proviso that the compound is not Tranilast.
    Type: Grant
    Filed: July 5, 2007
    Date of Patent: July 1, 2014
    Assignee: Fibrotech Therapeutics Pty Ltd
    Inventors: Spencer John Willams, David Stapleton, Steven Zammit, Darren James Kelly, Richard Ernest Gilbert, Henry Krum
  • Halogenated analogues of anti-fibrotic agents
    Patent number: 8624056
    Abstract: The present invention relates to halogenated compounds of formula (I) with the substituents as described within the specification. The compounds may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: January 7, 2014
    Inventors: Darren James Kelly, Spencer John Williams, Steven Zammit
  • FUSED RING ANALOGUES OF ANTI-FIBROTIC AGENTS
    Publication number: 20130338151
    Abstract: The present invention relates to arylcarbonyl and heteroarylcarbonyl anthranilate compounds that may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment disorders.
    Type: Application
    Filed: October 21, 2010
    Publication date: December 19, 2013
    Applicant: Fibrotech Therapeutics Pty Ltd
    Inventors: Spencer John Williams, Steven Zammit, Darren James Kelly
  • METHODS OF TREATING EYE DISEASES ASSOCIATED WITH INFLAMMATION AND VASCULAR PROLIFERATION
    Publication number: 20130310386
    Abstract: Methods for treating eye diseases associated with inflammation and/or vascular proliferation in subjects are disclosed. The methods include administering therapeutically effective amounts of a tranilast compound, in particular (E)-2-[[3-(3-Methoxy-4-propargyloxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or (E)-2-[[3,4-Bis(difluoromethoxy)phenyl)-1-oxo-2-propenyl]amino]benzoic acid or pharmaceutically acceptable salts or solvates thereof.
    Type: Application
    Filed: November 10, 2011
    Publication date: November 21, 2013
    Applicant: Fibrotech Therapeutics Pty Ltd
    Inventors: Darren James Kelly, David Stapleton
  • FUSED RING ANALOGUES OF ANTI-FIBROTIC AGENTS
    Publication number: 20120270863
    Abstract: The present invention relates to arylcarbonyl and heteroarylcarbonyl anthranilate compounds that may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment disorders.
    Type: Application
    Filed: October 21, 2010
    Publication date: October 25, 2012
    Applicant: Fibrotech Therapeutics Pty Ltd
    Inventors: Spencer John Williams, Steven Zammit, Darren James Kelly
  • HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS
    Publication number: 20120059188
    Abstract: The present invention relates to halogenated compounds of formula (I) with the substituents as described within the specification. The compounds may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation.
    Type: Application
    Filed: December 19, 2008
    Publication date: March 8, 2012
    Applicants: The University of Melbourne, Fibrotech Therapeutics Pty Ltd
    Inventors: Darren James Kelly, Spencer John Williams, Steven Zammit