Patents by Inventor David A. Ahlquist

David A. Ahlquist has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10370726
    Abstract: Provided herein is technology for colorectal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of colorectal neoplasia in 1) individuals at, older or younger than 50 years of age, or 2) individuals having Lynch Syndrome.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: August 6, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: David A. Ahlquist, William R. Taylor, John B. Kisiel, Tracy C. Yab, Douglas W. Mahoney
  • Publication number: 20190161806
    Abstract: Provided herein is technology for breast cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of breast cancer.
    Type: Application
    Filed: November 28, 2018
    Publication date: May 30, 2019
    Inventors: David A. Ahlquist, William R. Taylor, Douglas W. Mahoney, Tracy C. Yab, John B. Kisiel, Hatim T. Allawi, Graham P. Lidgard, Michael W. Kaiser
  • Publication number: 20190161804
    Abstract: Provided herein is technology for pancreatic high-grade dysplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of pancreatic high-grade dysplasia (IPMN-HGD, PanIN-3, or PDAC).
    Type: Application
    Filed: April 13, 2017
    Publication date: May 30, 2019
    Inventors: David A. Ahlquist, William R. Taylor, John B. Kisiel, Tracy C. Yab, Douglas W. Mahoney
  • Publication number: 20190161805
    Abstract: Provided herein is technology for breast cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of breast cancer.
    Type: Application
    Filed: November 28, 2018
    Publication date: May 30, 2019
    Inventors: David A. Ahlquist, William R. Taylor, Douglas W. Mahoney, Tracy C. Yab, John B. Kisiel, Hatim T. Allawi, Graham P. Lidgard, Michael W. Kaiser
  • Publication number: 20190127808
    Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting neoplasms such as cholangiocarcinoma.
    Type: Application
    Filed: January 8, 2019
    Publication date: May 2, 2019
    Inventors: John B. Kisiel, David A. Ahlquist, William R. Taylor, Douglas W. Mahoney, Tracy C. Yab
  • Patent number: 10184154
    Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting neoplasms such as cholangiocarinoma.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: January 22, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: John B. Kisiel, David A. Ahlquist, William R. Taylor, Douglas W. Mahoney, Tracy C. Yab
  • Publication number: 20180320240
    Abstract: Provided herein is technology for gastrointestinal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of gastrointestinal neoplasm, and classifying the site location of such a gastrointestinal neoplasm (e.g., a colorectal region, a pancreaticobiliary region, a gastroesophageal region).
    Type: Application
    Filed: July 9, 2018
    Publication date: November 8, 2018
    Inventors: David A. Ahlquist, William R. Taylor, John B. Kisiel, Douglas W. Mahoney, Tracy C. Yab
  • Publication number: 20180258498
    Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer.
    Type: Application
    Filed: May 14, 2018
    Publication date: September 13, 2018
    Inventors: David A. Ahlquist, John B. Kisiel, William R. Taylor, Tracy C. Yab, Douglas W. Mahoney, Graham P. Lidgard, Hatim T. Allawi
  • Publication number: 20180251859
    Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as gastric cancer.
    Type: Application
    Filed: May 4, 2018
    Publication date: September 6, 2018
    Inventors: David A. Ahlquist, William R. Taylor, John B. Kisiel, Tracy C. Yab, Douglas W. Mahoney, Hatim T. Allawi
  • Publication number: 20180245163
    Abstract: Provided herein is technology for prostate cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of prostate cancer.
    Type: Application
    Filed: February 27, 2018
    Publication date: August 30, 2018
    Inventors: David A. Ahlquist, William R. Taylor, John B. Kisiel, Tracy C. Yab, Douglas W. Mahoney, Brian A. Dukek, Matthew T. Gettman, Hatim T. Allawi
  • Patent number: 10030272
    Abstract: Provided herein is technology for gastrointestinal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of gastrointestinal neoplasm, and classifying the site location of such a gastrointestinal neoplasm (e.g., a colorectal region, a pancreaticobiliary region, a gastroesophageal region).
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: July 24, 2018
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: David A. Ahlquist, William R. Taylor, John B. Kisiel, Douglas W. Mahoney, Tracy C. Yab
  • Publication number: 20180187270
    Abstract: The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers (e.g., markers associated with colorectal cancer, markers associated with adenoma) in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals (e.g., humans) having a colorectal neoplasm by detecting the presence and level of indicators of colorectal neoplasia such as, for example, long DNA (e.g., quantified by Alu PCR) and the presence and level of tumor-associated gene alterations (e.g., mutations in KRAS, APC, melanoma antigen gene, p53, BRAF, BAT26, PIK3CA) or epigenetic alterations (e.g., DNA methylation) (e.g., CpG methylation) (e.g., CpG methylation in coding or regulatory regions of bmp-3, bmp-4, SFRP2, vimentin, septin9, ALX4, EYA4, TFPI2, NDRG4, FOXE1) in DNA from a stool sample obtained from the mammal.
    Type: Application
    Filed: February 19, 2018
    Publication date: July 5, 2018
    Inventors: Hongzhi Zou, David A. Ahlquist
  • Patent number: 10006093
    Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as gastric cancer.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: June 26, 2018
    Assignees: Mayo Foundation for Medical Education and Research, EXACT SCIENCES DEVELOPMENT COMPANY, LLC
    Inventors: David A. Ahlquist, William R. Taylor, John B. Kisiel, Tracy C. Yab, Douglas W. Mahoney, Hatim T. Allawi
  • Patent number: 9994911
    Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer. Accordingly, provided herein is technology for pancreatic cancer screening markers and other gastrointestinal cancer screening markers that provide a high signal to-noise ratio and a low background level when detected from samples taken from a subject (e.g., stool sample). As described herein, the technology provides a number of methylated DNA markers and subsets thereof (e.g., sets of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or more markers) with high discrimination for G1 neoplasms overall and/or at individual tumor sites.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: June 12, 2018
    Assignees: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, EXACT SCIENCES DEVELOPMENT COMPANY, LLC
    Inventors: David A. Ahlquist, John B. Kisiel, William R. Taylor, Tracy C. Yab, Douglas W. Mahoney, Graham P. Lidgard, Hatim T. Allawi
  • Patent number: 9982310
    Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: May 29, 2018
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: David A. Ahlquist, John B. Kisiel, William R. Taylor, Tracy C. Yab, Douglas W. Mahoney
  • Publication number: 20180105886
    Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.
    Type: Application
    Filed: October 4, 2017
    Publication date: April 19, 2018
    Inventors: William R. Taylor, Jonathan J. Harrington, Patrick S. Quint, Hongzhi Zou, Harold R. Bergen, III, David I. Smith, David A. Ahlquist
  • Publication number: 20180066320
    Abstract: Provided herein is technology for hepatocellular carcinoma screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of hepatocellular carcinoma.
    Type: Application
    Filed: September 1, 2017
    Publication date: March 8, 2018
    Inventors: William R. Taylor, David A. Ahlquist, Douglas W. Mahoney, John B. Kisiel, Tracy C. Yab, Hatim T. Allawi, Maria Giakoumopoulos, Graham P. Lidgard
  • Publication number: 20180037958
    Abstract: Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's esophageal dysplasia, and between Barrett's esophageal low-grade dysplasia, Barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. such as a capsule sponge, balloon, or other device).
    Type: Application
    Filed: March 23, 2016
    Publication date: February 8, 2018
    Applicants: Exact Sciences Corporation, Mayo Foundation for Medical Education and Research
    Inventors: David A. Ahlquist, William R. Taylor, John B. Kisiel, Douglas W. Mahoney, Tracy C. Yab, Graham P. Lidgard, Hatim T. Allawi
  • Publication number: 20170335401
    Abstract: Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer.
    Type: Application
    Filed: March 28, 2017
    Publication date: November 23, 2017
    Inventors: Hatim Allawi, Graham P. Lidgard, Maria Giakoumopoulos, David A. Ahlquist, William R. Taylor, Douglas Mahoney
  • Patent number: 9803249
    Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: October 31, 2017
    Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: William R. Taylor, Jonathan J. Harrington, Patrick S. Quint, Hongzhi Zou, Harold S. Bergen, III, David I. Smith, David A. Ahlquist