Abstract: A fulcrum prybar includes a shaft portion extending along a first axis, a curved prying portion affixed to a first end of the shaft portion, and a fulcrum portion affixed to the curved prying portion. The fulcrum portion includes two rectangular portions fused together to form an obtuse angle or a right angle cross section. One of the two rectangular portions is oriented such that it is flush with a horizontal surface while the prybar has partially raised an object from the same or another horizontal surface.

Abstract: Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific irreversible inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL irreversible inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.

Abstract: Disclosed herein are heterocyclic compounds, for example, according to the following formula and analogs thereof: that inhibit the activity of FLT3. Also described are specific covalent inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.

Abstract: A medical device such as a stent or medical balloon is functionalised prior to coating with a bioactive material, specifically by carboxylic acidification of the contact surface or surfaces of the medical device. The preferred process involves washing a stent or other medical device in a washing solution which may be sodium hydroxide, soaking in a carboxylic acid solution, rinsing in water to remove excess carboxylic acid, allowing to dry before applying a bioactive agent layer. It has been found that washing after functionalisation removes excess carboxylic acid and enhances the retention of bioactive agent on the contact surface or surfaces of the medical device leading to a more uniform and consistent layer of bioactive agent.

Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is (F). Also disclosed are methods of producing the cationic lipid of formula (I).

Abstract: Disclosed herein are multifunctional polypeptides comprising a first domain comprising an antigen binding domain (e.g., anti-synuclein, anti-tau, anti-huntingtin) and a second domain comprising a programmable proteasome-targeting PEST motif, and methods for using these polypeptides in treatment of protein aggregation diseases, e.g., neurodegenerative diseases.

Abstract: A system and a method for servicing user interactions are provided. The method includes: receiving, from each respective user, a respective request for a corresponding interaction; obtaining, for each interaction, request-specific information that relates to the received respective request and user-specific information that relates to the respective user; analyzing the request-specific information to determine at least one corresponding microservice that is usable for handling the interaction; and routing the request-specific information and the user-specific information to a respective destination that relates to the determined microservice. For any particular interaction, several corresponding microservices and several corresponding routes and destinations may be determined, and workload distribution metrics may be used to select optimum routes.

Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells.

Abstract: Disclosed herein are multifunctional polypeptides comprising a first domain comprising an anti-tau antigen binding domain and a second domain comprising a proteasome-targeting PEST motif, and methods for using these polypeptides in treatment of tauopathies.

Abstract: A fulcrum prybar includes a shaft portion extending along a first axis, a curved prying portion affixed to a first end of the shaft portion, and a fulcrum portion affixed to the curved prying portion. The fulcrum portion includes two rectangular portions fused together to form an obtuse angle or a right angle cross section. One of the two rectangular portions is oriented such that it is flush with a horizontal surface while the prybar has partially raised an object from the same or another horizontal surface.

Abstract: The present disclosure concerns a bearing for a piston rod body for a drug delivery device. The bearing has an axis and comprises a first and a second surface which are spaced apart in the direction of the axis and a third surface, wherein the third surface connects the first and the second surface, wherein an opening is provided in each of the first and the third surface, and wherein the opening in the first surface is connected to the opening in the third surface. Further, the present disclosure concerns a piston rod body and a piston rod arrangement comprising said bearing and the piston rod body.

Abstract: Systems and methods for providing a secure conversation gateway by which an audio voice stream is made to be replicable and convertible into other media types are provided. The method includes receiving an audio voice data stream; converting the received audio voice data stream into a predetermined media format; and transmitting the converted audio data stream to a user. The method may also include receiving an interaction event that corresponds to the audio data stream; generating metadata based on the interaction event; and applying a machine learning algorithm to the audio data stream and the metadata in order to generate a response that relates to the audio data stream. The method may also include replicating the audio data stream and distributing copies thereof to a set of recipients.

Abstract: Systems and method are directed to launching an application from a rail located within a user interface of a personal information manager application. More specifically, a display of a first user interface of a first application may be rendered at a display device, where the first user interface includes a rail populated with a plurality of icons representing a plurality of applications. At least one of the plurality of icons may be selected and a second application may be determined based on the selected icon. Based upon the selection of the icon, a display of a second user interface may be rendered within a portion of the first user interface.

Abstract: A system for interactive online instruction includes an instructional subscription website and video management system configured to process video recordings. The video recordings may include (i) student videos uploaded by a student and (ii) instructor videos providing feedback to said student videos. A method of interactive online instruction is also disclosed. The method includes the steps of providing prerecorded course materials on an instructional subscription website including video lessons accessible by subscribing students, and providing a video management system configured to process video recordings including (i) student videos submitted by a student and (ii) instructor videos providing feedback to said student videos.

Abstract: Systems and method are directed to launching an application from a rail located within a user interface of a personal information manager application. More specifically, a display of a first user interface of a first application may be rendered at a display device, where the first user interface includes a rail populated with a plurality of icons representing a plurality of applications. At least one of the plurality of icons may be selected and a second application may be determined based on the selected icon. Based upon the selection of the icon, a display of a second user interface may be rendered within a portion of the first user interface.

Abstract: A commercial hopper grain bin shell can be assembled on a concrete pad using jacks to successively support previously coupled side-wall panel rings above the concrete pad. The assembled shell can be supported above the concrete pad with the jacks while coupling a horizontal support beam around a bottom of the assembled commercial hopper grain bin shell. An uppermost ring of vertical support legs can be coupled to the horizontal support beam. An uppermost ring of hopper panels can be coupled to the horizontal support beam. The assembled shell and the vertical support legs previously coupled to the horizontal support beam can be successively supported above the concrete pad with jacks while coupling an additional ring of vertical support legs to the bottom of the previously coupled vertical support legs. An additional ring of hopper panels can be successively coupled to the bottom of the previously coupled hopper panels.

Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).

Abstract: Disclosed herein are multifunctional polypeptides comprising a first domain comprising an anti-tau antigen binding domain and a second domain comprising a proteasome-targeting PEST motif, and methods for using these polypeptides in treatment of tauopathies.

Abstract: A system and a method for servicing user interactions are provided. The method includes: receiving, from each respective user, a respective request for a corresponding interaction; obtaining, for each interaction, request-specific information that relates to the received respective request and user-specific information that relates to the respective user; analyzing the request-specific information to determine at least one corresponding microservice that is usable for handling the interaction; and routing the request-specific information and the user-specific information to a respective destination that relates to the determined microservice. For any particular interaction, several corresponding microservices and several corresponding routes and destinations may be determined, and workload distribution metrics may be used to select optimum routes.

Abstract: A system for interactive online instruction includes an instructional subscription website and video management system configured to process video recordings. The video recordings may include (i) student videos uploaded by a student and (ii) instructor videos providing feedback to said student videos. A method of interactive online instruction is also disclosed. The method includes the steps of providing prerecorded course materials on an instructional subscription website including video lessons accessible by subscribing students, and providing a video management system configured to process video recordings including (i) student videos submitted by a student and (ii) instructor videos providing feedback to said student videos.