Patents by Inventor David A. Knorr

David A. Knorr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10399048
    Abstract: Samples in an array of containers are processed by mounting the containers on a sample stage, moving magnets into proximity with bottoms of the containers of a first column of containers to apply a magnetic field, moving the magnets into proximity with bottoms of the containers of a second column, and moving heater elements into proximity with the container bottoms of the first column. While the magnetic field is applied to the containers of the second column, heat energy may be applied to the containers of the first column. The process may be repeated for additional columns. The containers may also be shaken to agitate the samples. A single apparatus may perform heating, shaking, and magnetic field application, without needing to transport the containers to different stations.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: September 3, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Chai Siong Siow, Thuan-Khim Khor, David Knorr
  • Publication number: 20190039034
    Abstract: Samples in an array of containers are processed by mounting the containers on a sample stage, moving magnets into proximity with bottoms of the containers of a first column of containers to apply a magnetic field, moving the magnets into proximity with bottoms of the containers of a second column, and moving heater elements into proximity with the container bottoms of the first column. While the magnetic field is applied to the containers of the second column, heat energy may be applied to the containers of the first column. The process may be repeated for additional columns. The containers may also be shaken to agitate the samples. A single apparatus may perform heating, shaking, and magnetic field application, without needing to transport the containers to different stations.
    Type: Application
    Filed: August 3, 2017
    Publication date: February 7, 2019
    Inventors: Chai Siong Siow, Thuan-Khim Khor, JR., David Knorr
  • Patent number: 9260696
    Abstract: A method for producing NK cells from pluripotent stem cells, which includes culturing pluripotent stem cells in a first serum-free medium, aggregating the undifferentiated stem cells to form embryoid bodies, which are cultured to produce hematopoietic precursor cells, and culturing the precursor cells in a serum-free medium to produce the NK cells. Methods for using such NK cells, e.g., in the treatment of cancer and infectious disease are also provided.
    Type: Grant
    Filed: April 23, 2013
    Date of Patent: February 16, 2016
    Inventors: Dan S. Kaufman, David A. Knorr
  • Patent number: 9103809
    Abstract: An automated liquid handling system is disclosed. A system includes a first pipetting group, which includes at least one pipettor, movably arranged on a first arm; and a second pipetting group, which includes at least one pipettor, movably arranged on a second arm, wherein the first arm and the second arm are movably arranged on at least one track such that the first arm and the second arm can independently move along the at least one track while keeping the first arm parallel with the second arm, wherein the at least one pipettor of the first pipetting group is arranged on a side of the first arm facing the second pipetting group, wherein the at least one pipettor of the second pipetting group is arranged on a side of the second arm facing the first pipetting group.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: August 11, 2015
    Assignee: Agilent Technologies, Inc.
    Inventors: Daniel West, David Knorr, James E. Young, Kimberly Subrahmanyan, Nicholas Fleming, Randy K. Roushall
  • Publication number: 20130287751
    Abstract: A method for producing NK cells from pluripotent stem cells, which includes culturing pluripotent stem cells in a first serum-free medium, aggregating the undifferentiated stem cells to form embryoid bodies, which are cultured to produce hematopoietic precursor cells, and culturing the precursor cells in a serum-free medium to produce the NK cells. Methods for using such NK cells, e.g., in the treatment of cancer and infectious disease are also provided.
    Type: Application
    Filed: April 23, 2013
    Publication date: October 31, 2013
    Inventors: Dan S. KAUFMAN, David A. KNORR
  • Publication number: 20130280145
    Abstract: An automated liquid handling system is disclosed. A system includes a first pipetting group, which includes at least one pipettor, movably arranged on a first arm; and a second pipetting group, which includes at least one pipettor, movably arranged on a second arm, wherein the first arm and the second arm are movably arranged on at least one track such that the first arm and the second arm can independently move along the at least one track while keeping the first arm parallel with the second arm, wherein the at least one pipettor of the first pipetting group is arranged on a side of the first arm facing the second pipetting group, wherein the at least one pipettor of the second pipetting group is arranged on a side of the second arm facing the first pipetting group.
    Type: Application
    Filed: April 23, 2012
    Publication date: October 24, 2013
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Daniel West, David Knorr, James E. Young, Kimberly Subrahmanyan, Nicholas Fleming, Randy K. Roushall
  • Patent number: 6316195
    Abstract: Karnal bunt of wheat is caused by Tilletia indica Mitra. Recently, teliospores morphologically resembling T. indica were isolated from bunted ryegrass seeds and wheat seed washes. Previously developed PCR assays failed to differentiate T. indica from the newly discovered ryegrass pathogen, T. walkeri. The nucleotide sequence of a 2.3-kb region of mitochondrial DNA, previously amplified by PCR only from T. indica, was determined for three isolates of T. indica and for three isolates of T. walkeri. There was greater than 99% identity within either the T. indica group or the T. walkeri group of isolates, whereas there was approximately 3% divergence between isolates of these two Tilletia species. Five sets of PCR primers were made specific to T. indica, and three sets were designed specifically for T. walkeri based upon nucleotide differences within the mtDNA region.
    Type: Grant
    Filed: December 23, 1999
    Date of Patent: November 13, 2001
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Reid D. Frederick, Paul W. Tooley, Morris R. Bonde, David A. Knorr, Gary L. Peterson, Norman W. Schaad