Abstract: The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.

Abstract: Disclosed are compositions and formulations comprising glucosamine or a pharmaceutically acceptable salt thereof for use in the treatment of joint conditions and adapted for use in a bath or soak or bath beads, powders, salts, and oils, kits, and methods of treatment using the same. Also disclosed are lozenges, suppositories, patches, and topical creams comprising glucosamine or a pharmaceutically acceptable salt thereof for use in the treatment of joint conditions and methods of treatment using the same. In some embodiments the joint conditions include osteoarthritis.

Abstract: Embodiments are directed to locally storing a snapshot of a personal information management web application, efficiently booting a personal information management web application and to managing personal information management web application snapshots. In one scenario, a client computer system determines that various portions of stored content for a personal information management web application have been changed. The client computer system creates a snapshot of certain, specified portions of data that are used for booting the personal information management web application and stores the created snapshot in local storage on the client computer system. As such, the snapshot is available for the next personal information management web application boot-up.

Abstract: A system for bootstrap provisioning of a device is provided. A vouching device is provisioned to access a bootstrap account of a bootstrap account provider and a secondary account of a secondary account provider. The bootstrap account provider stores an indication of the secondary account, and the secondary account provider stores verification data to verify a certification of the vouching device. A target device is provisioned to access the bootstrap account of the bootstrap account provider. The target device receives from the bootstrap account provider an indication that the target device is provisioned with the secondary account provider. The target device directs generation of a certification by the vouching device of target authentication data of the target device. The target device then sends the certification to the secondary account provider to effect the provisioning of the target device to access the secondary account.

Abstract: A three-dimensional spatial-awareness vision system includes video sensor system(s) mounted to a monitoring platform and having a field of view to monitor a scene of interest and provide real-time video data corresponding to real-time video images. A memory stores model data associated with a rendered three-dimensional virtual representation of the monitoring platform. An image processor combines the real-time video data and the model data to generate image data comprising the rendered three-dimensional virtual representation of the monitoring platform and the real-time video images of the scene of interest superimposed at a field of view relative to the rendered three-dimensional virtual representation of the monitoring platform.

Abstract: A laundry transfer apparatus comprising a wire frame within which is disposed a transfer conduit or shelf assembly that traverses a distance between the openings of a washing machine and dryer. A plurality of support wings and bumpers with friction pads are provided to enable the apparatus to rest on the top surfaces of a washing machine and dryer and to vertically suspend the apparatus so that the shelf assembly is appropriately positioned for each use. The conduit or shelf assembly preferably comprises a substantially planar surface composed of table sections that fold outward when the laundry transfer apparatus is in use. The shelf assembly is slidably engaged to the frame via sliding assembly. When use of the laundry transfer apparatus is complete, the individual sections are folded upright and pushed into a retracted position for later use.

Abstract: The invention relates to transgenic plants exhibiting increased cell wall content. In one embodiment, transgenic plants engineered to over-express fructokinase (FRK) or both FRK and sucrose synthase (SuSy) are provided. The FRK+SuSy double-transgenic plants of the invention consistently exhibit enhanced cell wall polymer deposition.

Abstract: The present invention relates to lipid compounds and uses thereof. In particular, the compounds include a class of cationic lipids having an amine moiety, such as an amino-amine or an amino-amide moiety. The lipid compounds are useful for in vivo or in vitro delivery of one or more agents (e.g., a polyanionic payload or an antisense payload, such as an RNAi agent).

Abstract: A surgical drape allows access to a vaginal area during cesarean sections without breaking a sterile field. The drape comprises a base sheet defined by an incision panel that overlays a peritoneal region, where the cesarean section primarily occurs; and a vagina panel that overlays a vaginal area. The incision panel has a transparent polymer film panel for viewing the incision. A collection pouch catches bodily fluids. The vagina panel enables sterile manipulation of the vagina while performing the cesarean section. The vagina panel is defined by a viewing pane for viewing the vaginal region through the base sheet. A sleeve extends through a hole in the viewing pane to manipulate the vaginal region and a baby. The sleeve is configured to allow insertion of a hand through an open end, and then manipulate the vaginal region with a closed end without breaking a sterile field.

Abstract: The present invention provides preparation of medicaments for use in treating and methods of treating cancer selected from the group consisting of gastric cancer, HCC, and RCC comprising a C8-H241 Ab, preferably, C8-H241-IgG4, more preferably, emibetuzumab, in combination, as described herein, with an anti-VEGFR2 Ab, preferably, ramucirumab.

Abstract: The described invention relates to methods for preventing or treating graft-versus-host disease while preserving a graft-versus-tumor effect, increasing survival of, preserving alloreactivity, or a combination thereof in a patient with a tumor receiving a transplant. The described methods comprise administering to the patient a therapeutic amount of a pharmaceutical composition comprising a Rho kinase inhibitor compound, e.g., telmisartan or related angiotensin receptor blockers, and a pharmaceutically acceptable excipient. The therapeutic amount may be effective to attenuate graft-versus-host disease and to preserve the graft-versus-tumor effect of the transplant.

Abstract: A laundry transfer apparatus comprising a frame within which is disposed a transfer conduit that traverses a distance between the openings of a washing machine and dryer. A plurality of upper extensions are provided to enable the apparatus to rest on the top surfaces of the washing machine and dryer and to vertically suspend the apparatus so that the conduit is appropriately positioned for each use. The conduit preferably comprises a substantially planar surface formed by individual table sections that fold out to form the conduit when the laundry transfer apparatus is in use. The conduit is slidably engaged to the frame via a railing. When use of the laundry transfer apparatus is complete, the individual sections are folded upright and pushed into a retracted position for later use.

Abstract: A system for bootstrap provisioning of a device is provided. A vouching device is provisioned to access a bootstrap account of a bootstrap account provider and a secondary account of a secondary account provider. The bootstrap account provider stores an indication of the secondary account, and the secondary account provider stores verification data to verify a certification of the vouching device. A target device is provisioned to access the bootstrap account of the bootstrap account provider. The target device receives from the bootstrap account provider an indication that the target device is provisioned with the secondary account provider. The target device directs generation of a certification by the vouching device of target authentication data of the target device. The target device then sends the certification to the secondary account provider to effect the provisioning of the target device to access the secondary account.

Abstract: A method for telephony includes receiving at an Internet telephony service provider a subscriber request to place a call to a telephone number. A cache associated with the internet telephony service provider is queried to check if the cache holds a record for the telephone number. If the cache holds the record, the record is obtained. If the cache does not hold the record, a request is sent to a database server that maintains a database of records associating endpoint user terminal telephone numbers of subscribers with respective packet network addresses of the endpoint user terminal. The call is placed to the endpoint user terminal telephone number via a public switched telephone network whilst the request is sent to the database server to retrieve the packet network address of the endpoint user terminal to which calls to the telephone number should be placed.

Abstract: The present invention includes various embodiments of a mobile app remote virtualization system and process that enables users of remote client devices to control mobile apps running in a host server environment. The resulting user experience is practically equivalent to running native mobile apps, even when such mobile apps require access to local client device resources, as well as when native versions of such mobile apps do not exist for the user's client device. The functionality afforded by the mobile app remote virtualization system and process of the present invention enables a variety of novel scenarios and “use cases” that have not previously been available to mobile device users.

Abstract: The present disclosure provides high-performance immunoreagents for use in a variety of immunologic assays and other related techniques. The immunoreagents comprise a primary antibody and a bridging antigen, wherein the bridging antigen is recognized by a detectable secondary antibody with high affinity. Also provided are compositions comprising panels of immunoreagents specific for multiple different target antigens and compositions comprising pairs of primary immunoreagents and their complementary detectable secondary antibodies. The paired primary immunoreagents and secondary antibodies are useful in a variety of immunologic assays, particularly in highly multiplexed assays, where the structure of the bridging antigen is varied in tandem with variation in the detectable secondary antibody, such that a multiplicity of immunoreagents are provided that are capable of simultaneously detecting a multiplicity of target antigens in a single assay.

Abstract: A method for telephony includes receiving at an Internet telephony service provider a subscriber request to place a call to a telephone number. A cache associated with the internet telephony service provider is queried to check if the cache holds a record for the telephone number. If the cache holds the record, the record is obtained. If the cache does not hold the record, a request is sent to a database server that maintains a database of records associating endpoint user terminal telephone numbers of subscribers with respective packet network addresses of the endpoint user terminal. The call is placed to the endpoint user terminal telephone number via a public switched telephone network while the request is sent to the database server to retrieve the packet network address of the endpoint user terminal to which calls to the telephone number should be placed.

Abstract: An experiment management system for an online visual design system including an experiment creator to receive an experiment specification with source material from an external source and to create an experiment definition based on inspection and analysis of the source material; an experiment integrator to integrate the experiment definition as an experiment into the experiment management system; an experiment configurer to configure a variant and population selection criteria for the experiment and an experiment manager to manage the experiment and at least one other experiment during the execution of the experiment at runtime of the online visual design system according to the variant and population selection.

Abstract: Embodiments are directed to implementing locale-based sorting and to creating temporary metadata sorting values. In one scenario, a computer system sends a request for a contact list, where the request includes an indication of the user's locale. The contact list includes contact information for contacts of a specified user. The computer system receives the requested contact list, which includes various portions of appended, locale-specific sorting metadata for at least one of the user's contacts' fields. The computer system then sorts the contacts of the contact list according to the selected sorting criterion using the sorting metadata, where the sorting metadata includes a sorting order specific to the user's locale. After the contacts are sorted, the computer system presents the sorted contacts to the user in a user interface.

Abstract: Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.