Abstract: Systems, methods, and articles of manufacture are disclosed that enable the compression of depth data and real-time reconstruction of high-quality light fields. In one aspect, spatial compression and decompression of depth images is divided into the following stages: generating a quadtree data structure for each depth image captured by a light field probe and difference mask associated with the depth image, with each node of the quadtree approximating a corresponding portion of the depth image data using an approximating function; generating, from the quadtree for each depth image, a runtime packed form that is more lightweight and has a desired maximum error; and assembling multiple such runtime packed forms into per-probe stream(s); and decoding at runtime the assembled per-probe stream(s). Further, a block compression format is disclosed for approximating depth data by augmenting the block compression format 3DC+(BC4) with a line and two pairs of endpoints.

Abstract: Provided herein are secretory compositions/cocktails derived from a novel, extremophilic fungal species cultured, isolated, and characterized herein. Said novel, extremophilic fungal species may be exploited to produce secretory compositions/cocktails which comprise a unique mixture of thermo-tolerant, stable enzymes capable of digesting cellular and genetic material in its surroundings under extreme temperatures. Such secretory compositions/cocktails may be useful as cleaning and sterilization solutions against biofilm, urine, yeast, bacterial, or viral contamination. Other uses include, but are not limited to, urea removal, fertilizer wastewaters, wastewater reclamation for life support systems in space, pH control, source of ammonia and carbon dioxide, starch digestion, biofuel production, as pharmaceuticals, and medical treatments such as wounds, skin disorders, or nail disorders.

Abstract: Provided herein are secretory compositions/cocktails derived from a novel, extremophilic fungal species cultured, isolated, characterized and sequenced herein. Said novel, extremophilic fungal species may be exploited to produce a secretory compositions/cocktails which comprise a unique mixture of thermo-tolerant, stable enzymes capable of digesting cellular and genetic material in its surroundings under extreme temperatures. Such secretory compositions/cocktails may be useful as cleaning and sterilization solutions against biofilm, urine, yeast, bacterial, or viral contamination. Other uses include, but are not limited to, urea removal, fertilizer wastewaters, wastewater reclamation for life support systems in space, pH control, source of ammonia and carbon dioxide, starch digestion, biofuel production, as pharmaceuticals, and medical treatments such as wounds, skin disorders, or nail disorders.

Abstract: Methods and compositions for preventing or treating peripheral neuropathy, cognitive deficits, inactivity, depression, chemotherapy and/or radiotherapy induced peripheral neuropathy and cognitive deficits, and improving cognitive performance, in a subject in need thereof are disclosed. The disclosed methods include the step of administering to the subject an effective amount of an agent that increases the level of NAD+ in the subject.

Abstract: The invention provides compositions comprising agents which modulate poly(ADP-ribose)polymerase 14 (PARP14), or compositions comprising PARP14 mutants. Such compositions can modulate the levels of nicotinamide adenine dinucleotide (NAD+) and are useful in methods for treating or preventing cancer, aging, aging-related disorders, cell death, radiation damage, radiation exposure, disorders associated with inflammation, among others. Such compositions and methods may also improve DNA repair, cell proliferation, cell survival, modulate inflammatory response, among others, and may increase the life span of a cell or protect it against certain stresses, apoptosis, among others.

Abstract: The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.

Abstract: Disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension of life span. Also described herein are methods for the identification of agents useful in the foregoing methods. Methods and compositions are provided for the treatment of diseases or disorders associated with mitochondrial dysfunction.

Abstract: A device for compressing subject data. the device comprises a communication link, the communication link capable of receiving a set of subject data; a compression module, the compression module configured to apply a compression algorithm to the set of subject data, the compression algorithm compressing the set of subject data using a reference string of subject data; and a transmission module, the transmission module configured to transmit the compressed subject data. The device further comprising an encryption module for encrypting the subject data.

Abstract: Systems, methods, and articles of manufacture for real-time rendering using compressed animated light fields are disclosed. One embodiment provides a pipeline, from offline rendering of an animated scene from sparse optimized viewpoints to real-time rendering of the scene with freedom of movement, that includes three stages: offline preparation and rendering, stream compression, and real-time decompression and reconstruction. During offline rendering, optimal placements for cameras in the scene are determined, and color and depth images are rendered using such cameras. Color and depth data is then compressed using an integrated spatial and temporal scheme permitting high performance on graphics processing units for virtual reality applications.

Abstract: Methods and compositions for preventing or treating peripheral neuropathy, cognitive deficits, inactivity, depression, chemotherapy and/or radiotherapy induced peripheral neuropathy and cognitive deficits, and improving cognitive performance, in a subject in need thereof are disclosed. The disclosed methods include the step of administering to the subject an effective amount of an agent that increases the level of NAD+ in the subject.

Abstract: The invention provides methods and compositions for inhibiting CD38 activity, and methods of treating or preventing various disorders associated with CD38 activity.

Abstract: The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.

Abstract: The invention provides methods of modulating and regulating NHD protein-protein interactions through nicotinamide mononucleotide, analogs and derivatives thereof, such as NAD+.

Abstract: The invention relates to modulation of SIRT3 activity levels. The invention has applications for regulating metabolism and mimicking caloric restriction or exercise in a muscle cell.

Abstract: Systems, methods, and articles of manufacture are disclosed that enable the compression of depth data and real-time reconstruction of high-quality light fields. In one aspect, spatial compression and decompression of depth images is divided into the following stages: generating a quadtree data structure for each depth image captured by a light field probe and difference mask associated with the depth image, with each node of the quadtree approximating a corresponding portion of the depth image data using an approximating function; generating, from the quadtree for each depth image, a runtime packed form that is more lightweight and has a desired maximum error; and assembling multiple such runtime packed forms into per-probe stream(s); and decoding at runtime the assembled per-probe stream(s). Further, a block compression format is disclosed for approximating depth data by augmenting the block compression format 3DC+(BC4) with a line and two pairs of endpoints.

Abstract: Provided herein are secretory compositions/cocktails derived from a novel, extremophilic fungal species cultured, isolated, characterized and sequenced herein. Said novel, extremophilic fungal species may be exploited to produce a secretory compositions/cocktails which comprise a unique mixture of thermo-tolerant, stable enzymes capable of digesting cellular and genetic material in its surroundings under extreme temperatures. Such secretory compositions/cocktails may be useful as cleaning and sterilization solutions against biofilm, urine, yeast, bacterial, or viral contamination. Other uses include, but are not limited to, urea removal, fertilizer wastewaters, wastewater reclamation for life support systems in space, pH control, source of ammonia and carbon dioxide, starch digestion, biofuel production, as pharmaceuticals, and medical treatments such as wounds, skin disorders, or nail disorders.

Abstract: Enzyme-based systems and methods for synthesizing the NAD precursors NMN and NaMN are disclosed. Such methods and systems utilize a mutated form of phosphoribosylpyrophosphate synthetase (PRS) that is superactive and/or other enzyme or enzyme combinations that are immobilized onto a solid surface. The methods and systems substantially increase the efficiency and yield of NAD precursor synthesis.

Abstract: In vivo methods using bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures, are described.

Abstract: Disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension of life span. Also described herein are methods for the identification of agents useful in the foregoing methods. Methods and compositions are provided for the treatment of diseases or disorders associated with mitochondrial dysfunction. The invention relates to methods for treatment and prevention of cancer by administering agents that increase levels of NAD+, such as NAD+ precursors or agents involved in NAD+ biosynthesis.

Abstract: Systems, methods, and articles of manufacture for real-time rendering using compressed animated light fields are disclosed. One embodiment provides a pipeline, from offline rendering of an animated scene from sparse optimized viewpoints to real-time rendering of the scene with freedom of movement, that includes three stages: offline preparation and rendering, stream compression, and real-time decompression and reconstruction. During offline rendering, optimal placements for cameras in the scene are determined, and color and depth images are rendered using such cameras. Color and depth data is then compressed using an integrated spatial and temporal scheme permitting high performance on graphics processing units for virtual reality applications.