Patents by Inventor David A Stenger

David A Stenger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190033247
    Abstract: An electrochemical cell includes a working electrode in contact with an aqueous electrolyte solution, a counter electrode in contact with the aqueous electrolyte solution, and a reference electrode in contact with the aqueous electrolyte solution. The working electrode comprises a plasma modified epitaxial synthesized graphene surface fabricated on SiC.
    Type: Application
    Filed: July 30, 2018
    Publication date: January 31, 2019
    Inventors: Scott A. Trammell, Rachael L. Myers-Ward, Sandra C. Hangarter, Daniel Zabetakis, David A. Stenger, David Kurt Gaskill, Scott G. Walton
  • Patent number: 9857294
    Abstract: Described herein is an approach using inexpensive, disposable chemical sensor probes that can be mounted on a small unmanned aerial vehicles (UAVs) and used to analyze a site (such as one known or suspected to contain explosive residue, spilled material or contaminated soil) without the need for a person to conduct ground operations at the site. The method involves contacting a soil or a surface with a filter paper wetted with a solvent, then subjecting the filter paper to spectroscopy, thus detecting a possible variation indicative of one or more analytes, wherein the solvent is a deep eutectic solvents consisting of a mixture of ethylene glycol and choline chloride.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: January 2, 2018
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, Scott A. Trammell, Walter J. Dressick, David A. Stenger, Jasenka Verbarg
  • Patent number: 9857293
    Abstract: Described herein is an approach using inexpensive, disposable chemical sensor probes that can be mounted on a small unmanned aerial vehicles (UAVs) and used to analyze a site (such as one known or suspected to contain explosive residue, spilled material or contaminated soil) without the need for a person to conduct ground operations at the site. The method involves contacting a soil or a surface with a filter paper wetted with a solvent, then subjecting the filter paper to voltammetry and/or spectroscopy, thus detecting a possible variation indicative of one or more analytes, wherein the solvent is the deep eutectic solvent consisting of a mixture of ethylene glycol and choline chloride.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: January 2, 2018
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, Scott A. Trammell, Walter J. Dressick, David A. Stenger, Jasenka Verbarg
  • Publication number: 20170343471
    Abstract: Systems and methods are provided for identification of a detection event relevant in applications focused on real-time or near real-time reporting in a continuous monitoring application. A controller collects data from a plurality of sensors and compares recent data to background data to determine whether an event has occurred. A system in accordance with an embodiment of the present disclosure is considered to have detected an event of interest when at least a specified minimum number of sensors report a detection event at the same time.
    Type: Application
    Filed: May 27, 2017
    Publication date: November 30, 2017
    Inventors: Anthony P. Malanoski, Brandy J. White, Jeffrey S. Erickson, David A. Stenger
  • Publication number: 20170074785
    Abstract: Described herein is an approach using inexpensive, disposable chemical sensor probes that can be mounted on a small unmanned aerial vehicles (UAVs) and used to analyze a site (such as one known or suspected to contain explosive residue, spilled material or contaminated soil) without the need for a person to conduct ground operations at the site. The method involves contacting a soil or a surface with a filter paper wetted with a solvent, then subjecting the filter paper to spectroscopy, thus detecting a possible variation indicative of one or more analytes, wherein the solvent is a deep eutectic solvents consisting of a mixture of ethylene glycol and choline chloride.
    Type: Application
    Filed: November 18, 2016
    Publication date: March 16, 2017
    Inventors: Daniel Zabetakis, Scott A. Trammell, Walter J. Dressick, David A. Stenger, Jasenka Verbarg
  • Publication number: 20170074825
    Abstract: Described herein is an approach using inexpensive, disposable chemical sensor probes that can be mounted on a small unmanned aerial vehicles (UAVs) and used to analyze a site (such as one known or suspected to contain explosive residue, spilled material or contaminated soil) without the need for a person to conduct ground operations at the site. The method involves contacting a soil or a surface with a filter paper wetted with a solvent, then subjecting the filter paper to voltammetry and/or spectroscopy, thus detecting a possible variation indicative of one or more analytes, wherein the solvent is the deep eutectic solvent consisting of a mixture of ethylene glycol and choline chloride.
    Type: Application
    Filed: November 18, 2016
    Publication date: March 16, 2017
    Inventors: Daniel Zabetakis, Scott A. Trammell, Walter J. Dressick, David A. Stenger, Jasenka Verbarg
  • Patent number: 9557296
    Abstract: Described herein is an approach using inexpensive, disposable chemical sensor probes that can be mounted on a small unmanned aerial vehicles (UAVs) and used to analyze a site (such as one known or suspected to contain explosive residue, spilled material or contaminated soil) without the need for a person to conduct ground operations at the site. The method involves contacting a soil or a surface with a filter paper wetted with a solvent, then subjecting the filter paper to voltammetry and/or spectroscopy, thus detecting a possible variation indicative of one or more analytes, wherein the solvent is selected from the group consisting of polar aprotic or protic solvents having a boiling point of at least 100° C., room temperature ionic liquids, and deep eutectic solvents.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: January 31, 2017
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, Scott A. Trammell, Walter J. Dressick, David A. Stenger, Jasenka Verbarg
  • Patent number: 9430610
    Abstract: The present invention relates to pathogen detection and identification by use of DNA resequencing microarrays. The present invention also provides resequencing microarray chips for differential diagnosis and serotyping of pathogens present in a biological sample. The present invention further provides methods of detecting the presence and identity of pathogens present in a biological sample.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: August 30, 2016
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Brian K Agan, Eric H Hanson, Russell P Kruzelock, Baochuan Lin, Robb K Rowley, Donald Seto, David A Stenger, Jennifer Johnson, Clark J Tibbetts, Dzung C Thach, Gary J Vora, Elizabeth A Walter, Zheng Wang
  • Publication number: 20160061775
    Abstract: Described herein is an approach using inexpensive, disposable chemical sensor probes that can be mounted on a small unmanned aerial vehicles (UAVs) and used to analyze a site (such as one known or suspected to contain explosive residue, spilled material or contaminated soil) without the need for a person to conduct ground operations at the site. The method involves contacting a soil or a surface with a filter paper wetted with a solvent, then subjecting the filter paper to voltammetry and/or spectroscopy, thus detecting a possible variation indicative of one or more analytes, wherein the solvent is selected from the group consisting of polar aprotic or protic solvents having a boiling point of at least 100° C., room temperature ionic liquids, and deep eutectic solvents.
    Type: Application
    Filed: August 27, 2014
    Publication date: March 3, 2016
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, Scott A. Trammell, Walter J. Dressick, David A. Stenger, Jasenka Verbarg
  • Patent number: 9096849
    Abstract: A method of: providing a solid surface having a dendrimer molecule bound thereto and a single-stranded probe nucleic acid immobilized to the dendrimer; contacting the solid surface with a sample suspected or known to contain a double-stranded complimentary target nucleic acid; denaturing the target nucleic acids at thermal conditions and in a salt concentration sufficient to denature the target nucleic acids to produce denatured nucleic acids; and cooling the sample to allow hybridization of the denatured nucleic acids to the probe nucleic acids. An article having: one or more paramagnetic microbeads; a dendrimer molecule bound to the beads; and a probe nucleic acid immobilized to the dendrimer.
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: August 4, 2015
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Marie J. Archer, Baochuan Lin, David A Stenger
  • Patent number: 8965710
    Abstract: An apparatus having within or as part of a housing; a sample port; a microarray port; a lysis module; a purification module for containing a solid phase for binding of oligonucleotides; a thermocycling module for containing a polymerase chain reaction; a fragmentation module; and a microarray module for holding a microarray and a liquid in contact with the microarray. The apparatus is configured to be coupled to a device for: pumping a liquid through, in order, the lysis, purification, thermocycling, fragmentation, and microarray modules; sonicating any contents of the lysis module; thermocycling the thermocycling module to perform the polymerase chain reaction; heating the fragmentation module to fragment any oligonucleotides contained therein; circulating a fluid over the surface of the microarray; and performing one or more washing or staining steps on the microarray.
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: February 24, 2015
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Frances S Ligler, David A Stenger, Jeff Erickson, Marie Archer
  • Publication number: 20120035857
    Abstract: A computer-implemented biological sequence identifier (CIBSI) system and method for selecting a subsequence from biological sequence data according to at least one selection parameter. The at least one selection parameter corresponds to a likelihood of returning a meaningful result from a similarity search.
    Type: Application
    Filed: August 17, 2011
    Publication date: February 9, 2012
    Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY
    Inventors: David A. Stenger, Jennifer Thornton
  • Patent number: 8032310
    Abstract: A computer-implemented biological sequence identifier (CIBSI) system and method for selecting a subsequence from biological sequence data according to at least one selection parameter. The at least one selection parameter corresponds to a likelihood of returning a meaningful result from a similarity search.
    Type: Grant
    Filed: July 2, 2005
    Date of Patent: October 4, 2011
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: David A Stenger, Jennifer Thornton
  • Publication number: 20110183856
    Abstract: The present invention provides a specific set of gene expression markers from peripheral blood leukocytes that are indicative of a host response to exposure, response, and recovery infectious pathogen infections. The present invention further provides methods for identifying the specific set of gene expression markers, methods of monitoring disease progression and treatment of infectious pathogen infections, methods of prognosing the onset of an infectious pathogen infection, and methods of diagnosing an infectious pathogen infection and identifying the pathogen involved.
    Type: Application
    Filed: February 26, 2010
    Publication date: July 28, 2011
    Applicants: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Brian K. Agan, Eric H. Hanson, Michael J. Jenkins, Baochuan Lin, Chris C. Olsen, Robb K. Rowley, David A. Stenger, Dzung C. Thach, Clark J. Tibbetts, Elizabeth A. Walter, Jinny Lin Liu
  • Patent number: 7979446
    Abstract: A method of: submitting reference sequences to a taxonomic database to produce taxonomic results; and reporting a taxonomic identification based on the taxonomic results. The reference sequences are the output of genetic database queries that return a score for each reference sequence. A method for processing a biological sequence obtained from an assay by: converting base calls located in a predetermined list of positions within the biological sequence to N; and determining the ratio of single nucleotide polymorphisms in the biological sequence relative to a reference sequence. Each entry in the predetermined list of positions represents the capability of a substance hybridizing to a microarray used to generate the biological sequence. The substance is not the nucleic acid of a target pathogen.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: July 12, 2011
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Anthony P. Malanoski, Baochuan Lin, Joel M Schnur, David A Stenger
  • Patent number: 7785769
    Abstract: The use of sugar-containing hydrogels as very highly porous, aqueous support material for the immobilization of oligonucleotides, peptides, proteins, antigens, antibodies, polysaccharides, and other biomolecules for sensor applications. Unusually large sizes of interconnected pores allow large target molecules to pass rapidly into and through the gel and bind to immobilized biomolecules. Sugar-containing hydrogels have extremely low non-specific absorption of labeled target molecules, providing low background levels. Some hydrogel materials do not have this type of homogeneous interconnected macroporosity, thus large target molecules cannot readily diffuse through them. Additionally, they nearly always experience non-specific absorption of labeled target molecules, limiting their usefulness in sensor applications. A method is provided for preparing sugar polyacrylate hydrogels with functional chemical groups which covalently bond oligonucleotides and peptides.
    Type: Grant
    Filed: July 25, 2003
    Date of Patent: August 31, 2010
    Assignee: The United States of America as reprsented by the Secretary of the Navy
    Inventors: Mark S. Spector, David A. Stenger, Charles H. Patterson, Jr., Brett D. Martin, Paul T. Charles
  • Patent number: 7785770
    Abstract: The use of sugar-containing hydrogels as very highly porous, aqueous support material for the immobilization of oligonucleotides, peptides, proteins, antigens, antibodies, polysaccharides, and other biomolecules for sensor applications. Unusually large sizes of interconnected pores allow large target molecules to pass rapidly into and through the gel and bind to immobilized biomolecules. Sugar-containing hydrogels have extremely low non-specific absorption of labeled target molecules, providing low background levels. Some hydrogel materials do not have this type of homogeneous interconnected macroporosity, thus large target molecules cannot readily diffuse through them. Additionally, they nearly always experience non-specific absorption of labeled target molecules, limiting their usefulness in sensor applications. A method is provided for preparing sugar polyacrylate hydrogels with functional chemical groups which covalently bond oligonucleotides and peptides.
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: August 31, 2010
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Mark S. Spector, David A. Stenger, Charles H. Patterson, Jr., Brett D. Martin, Paul T. Charles
  • Publication number: 20100112643
    Abstract: A method of: providing a solid surface having a dendrimer molecule bound thereto and a single-stranded probe nucleic acid immobilized to the dendrimer; contacting the solid surface with a sample suspected or known to contain a target ribonucleic acid; denaturing the target ribonucleic acid; and incubating the sample to allow hybridization of the denatured ribonucleic acid to the probe nucleic acids. The target ribonucleic acid is complementary to the probe nucleic acid.
    Type: Application
    Filed: November 4, 2008
    Publication date: May 6, 2010
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Marie J. Archer, Baochuan Lin, David A. Stenger
  • Patent number: 7695941
    Abstract: A PCR method involving: providing a biological sample suspected of containing one or more pathogen nucleic acids; adding a plurality of PCR primers corresponding to genes found in the pathogens; and performing a polymerase chain reaction on the sample to amplify a subset of the nucleic acids that correspond to the genes. The primers include at least one primer pair for each pathogen, and the primers contain a tail sequence that is not homologous any pathogen DNA or to any background DNA in the sample. The concentration of at least one primer in the polymerase chain reaction is no more than about 100 nM.
    Type: Grant
    Filed: June 6, 2006
    Date of Patent: April 13, 2010
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Baochuan Lin, Kate M. Blaney, Anthony P. Malanoski, Joel M Schnur, David A Stenger
  • Publication number: 20100070195
    Abstract: A method of: submitting reference sequences to a taxonomic database to produce taxonomic results; and reporting a taxonomic identification based on the taxonomic results. The reference sequences are the output of genetic database queries that return a score for each reference sequence. A method for processing a biological sequence obtained from an assay by: converting base calls located in a predetermined list of positions within the biological sequence to N; and determining the ratio of single nucleotide polymorphisms in the biological sequence relative to a reference sequence. Each entry in the predetermined list of positions represents the capability of a substance hybridizing to a microarray used to generate the biological sequence. The substance is not the nucleic acid of a target pathogen.
    Type: Application
    Filed: November 12, 2009
    Publication date: March 18, 2010
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Anthony P. Malanoski, Baochuan Lin, Joel M. Schnur, David A. Stenger