Abstract: A plastic blow-molded container is disclosed having a penetrable wall portion or site which is sufficiently thin to permit piercing by a needle, spike or the like without coring or fragmenting, and a thicker recessed wall portion adjacent to the penetrable portion. The penetrable portion is formed during the blow-molding process by expanding the plastic parison over a projection in the mold cavity and into an adjacent recess in the cavity. The thin penetrable portion of the container is formed within the mold recess and the thicker recessed portion of the container is formed by the mold projection.

Abstract: A one-piece integral plastic container is disclosed which has an outer closure or overcap removable along a frangible line of weakness, and a separately-formed inner closure that is maintained in sterile condition by the outer closure until the container contents are dispensed. The inner closure comprises a tubular member inserted in fluid-tight relationship within the container neck after the container body and neck are molded, but prior to formation of the outer closure. The tubular member thus provides the dispensing outlet for the container and is maintained in sterile condition by the overcap which encloses it.

Abstract: A closure system for a container having a neck with a cap support flange extending radially outwardly around the neck. A resilient gasket encircles the neck and overlies the cap support flange, to be compressed by a closure cap which is attached to the neck for sealing. Annular rib means project from the support flange against the gasket to retain the gasket in its sealing position. A method is also described for the manufacturing of such a closure system.

Abstract: A molded collapsible solution container which defines a body portion having an integral neck portion and a relatively stiff shoulder portion and sealed at the opposite end, with gusset portions defined in the body portion adjacent the shoulder portion at opposite sides thereof. The shoulder portion extends outwardly from the neck portion and also extends axially rearwardly away from the neck portion in tapered manner. Sections of the shoulder portion adjacent the gusset portions normally extend in a plane perpendicular to the longitudinal axis of the container, being connected to the remainder of the shoulder portion by an angular crease line and being flexible to permit axially forward bending of the sections about the crease line as the container collapses by draining. Also, the tail seal at the opposite end may define a convex, arcuate seal for improved strength.

Abstract: A molded collapsible solution container defines a chamber-defining body portion wall having an integral neck portion and a shoulder portion at one end thereof. The container defines a pair of opposed gusset portions adjacent the shoulder portion at opposite ends of the shoulder portion, with the shoulder portion defining opposed shoulder edges extending between the gusset portions. A pair of opposed lines of flexing weakness are defined in the collapsible solution container and exhibit an arcuate cross section which extends inwardly of the container. The opposed lines of flexing weakness are positioned on each side of the container in generally parallel relation to the opposed shoulder edges with the opposed lines of flexing weakness being longitudinally spaced from the shoulder edges by a distance which is proportioned to cause the opposed lines of flexing weakness to abut one another as the container collapses inwardly about the opposed shoulder edges.

Abstract: A plastic hanger for medical containers or the like is described which, in its normal, unstressed position, lies adjacent the bottom of the container so as not to interfere with setting the container on a flat surface. The hanger is molded separately from the container and sealed or attached to a rib formed on the bottom of the container.

Abstract: A hermetically sealed container is provided in which a cup-shaped overcap overlies an externally threaded dispensing outlet and is hermetically bonded to the bottle neck. An outer jacket ring is provided to jack the overcap off of the bottle neck when the jacking ring is rotated downwardly. The overcap carries a wiper seal which engages the dispensing outlet to prevent liquid flow out of the dispensing outlet until the overcap is removed. The container closure is tamper-proof in that the overcap cannot be threadedly engaged with the externally threaded dispensing outlet once the overcap has been jacked off the bottle neck.

Abstract: A diagnostic reagent dispensing bottle which includes a flexible container having an elongated cap mounting neck which is closed by a pierceable or punctureable membrane. A membrane-piercing-and-droplet-dispensing spike is also provided. The spike includes a conically-shaped orifice and a sharp membrane piercing point. The spike is carried by an elongated cap which has a body portion for mounting on the neck of the container. The neck and cap cooperate to position the spike in either (1) a shipping or non-piercing position or (2) a dispensing position wherein the spike pierces the membrane so that the reagent within the container can flow through the spike for dispensing. The cap also includes a cover or closure for closing the bottle which is hingedly connected to the cap body so that the cover is selectively positionable in either an open or closed position. Both detent and thread systems are disclosed for cooperation with the cap and neck to position and guide the spike relative to the pierceable membrane.

Abstract: A molded collapsible solution container which container defines a chamber-defining body portion wall having an integral neck portion and shoulder portion at one end thereof. The container defines, in its normal, unstressed state, a transverse cross section which tapers from the shoulder portion progressively along a major portion of its length to a flat, sealed end portion at the end of the container opposite to the one end. In accordance with this invention, the shoulder portion is rectilinear in shape, with the wall circumferences of transverse cross sections preferably progressively decreasing in length along the container from adjacent the shoulder portion toward the opposite end. Opposed triangular gusset portions are preferably present in which the side of the gusset portion which is parallel to the shoulder edge is positioned directly against the shoulder edge, and the shoulder edge defines the shape of an enlarged, generally cylindrical section for ease of flexing.

Abstract: A cap closure is provided for bonding to the neck of a container. The cap closure includes a base portion enclosed by a side wall, a peripheral rim extending outwardly from the side wall with the rim being adapted for bonding to the neck of the container, an administration port connected to the base portion, a medication addition port connected to the base portion, a resealable injection site connected to the medication addition port, and port protectors covering and hermetically sealing the administration and medication addition ports. In the illustrative embodiment, the base portion, side wall, peripheral rim, administration port and medication addition ports are molded as an integral, unitary member, and a method is provided for fusing a membrane to the medication addition port and for fusing port protectors with the base member.

Abstract: The method of molding flexible, collapsible containers comprises extruding a tubular parison of material to be molded and sealing the outer, free end of the parison; ballooning the parison with relatively low pneumatic pressure; closing the mold about the ballooned parison to cause the edges of the parison to protrude out of the mold chamber; and sealing said parison to form said container, including the step of forming seal lines positioned laterally inwardly from the lateral edges of the parison. A novel container design is also covered.

Abstract: A container for storing and dispensing sterile liquids is provided with a hermetically sealed primary cap and overcap. The overcap and primary cap are provided, respectively, with an interlocking ring and undercut lip to provide for limited relative axial movement; the overcap and bottle neck are provided with interfitting lugs and ribs to provide for limited rotational movement. An outer ring has internal threads engaging external threads on the overcap and defines a jacking member whereby rotation of the outer ring moves the overcap upwardly to break the hermetic seals.

Abstract: A closure system is provided for a threaded container. A threaded closure cap has an annular skirt which engages a resilient gasket that is stretched over the bottle neck. The resilient gasket overlies a cap support flange which extends from the neck. Downward axial movement of the cap with respect to the container provides a vertical compressive force against the resilient gasket by the cap skirt. A heat shrinkable outer member surrounds the closure cap and provides a tamperproof seal with respect to the container.

Abstract: A thermoplastic pharmaceutical solution container includes a neck portion having at least one port through the neck portion. A thermoplastic port protector or closure covers the port and defines a frangible section. The closure has a length to diameter ratio providing good mechanical advantage leverage to rupture the frangible section when the closure is pushed sideways.

Abstract: The method of molding flexible, collapsible containers comprises extruding a tubular parison of material to be molded and sealing the outer, free end of the parison; ballooning the parison with relatively low pneumatic pressure; closing the mold about the ballooned parison to cause the edges of the parison to protrude out of the mold chamber; and sealing said parison to form said container, including the step of forming seal lines positioned laterally inwardly from the lateral edges of the parison. A novel container design is also covered.