Abstract: Disclosed are substituted pyridine compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure wherein E, J, T, the ring system denoted by “B”, T, R3, R4, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

Abstract: In embodiments, a drilling rig system includes a rig unit having rig equipment and a rig electrical subsystem configured for electrical communication with the rig equipment and including a rig electrical subsystem input transformer, an electrical system including a primary power supply subsystem remote from the rig unit, and an intermediate electrical subsystem.

Abstract: In embodiments, a drilling rig system includes a rig unit having rig equipment and a rig electrical subsystem configured for electrical communication with the rig equipment and including a rig electrical subsystem input transformer, an electrical system including a primary power supply subsystem remote from the rig unit, and an intermediate electrical subsystem.

Abstract: The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

Abstract: A fleet node management system may include a metadata store, a plurality of fleet nodes, and one or more metadata mutation devices. The metadata store may be configured to store dynamic metadata. The plurality of fleet nodes may be configured to determine, based on a gossip protocol, whether to continue performance of a function that uses a local version of the metadata. The one or more metadata mutation devices may be configured to determine, based on a global state of the fleet nodes, whether to modify the dynamic metadata for the fleet nodes.

Abstract: In one aspect, composite layers are described herein demonstrating phase-separated architectures which, in some embodiments, can mitigate performance disadvantages of prior organic layers of optoelectronic devices. A composite organic layer described herein comprises nanocluster nodes and carbon nanoparticles disposed in a conjugated polymeric host, wherein the carbon nanoparticles are substantially phase separated from the conjugated polymeric host forming lamellar structures of carbon nanofibrils radiating from the nanocluster nodes.

Abstract: Disclosed are substituted pyridine compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure wherein E, J, T, the ring system denoted by “B”, T, R3, R4, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

Abstract: The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

Abstract: An integrated tele-health networking, interaction, and care-matching tool for tele-health services may include a tele-health operations server in communication with patient, provider, matching, and interaction databases. A management engine running on the server may execute a database management module, a rule module, and a GUI module configured to display a GUI having a plurality of preconfigured screens at a plurality of user terminals. In operation, the management engine implements a referral-based care network that connects a patient with healthcare providers, non-medical-professional caregivers, advocates, and friends or family via the user terminals.

Abstract: The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

Abstract: The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.

Abstract: Disclosed are substituted pyridine compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure wherein E, J, T, the ring system denoted by “B”, T, R3, R4, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

Abstract: The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lupus erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

Abstract: The present invention provides a skin surface sampling device in which a supply tube and a recovery tube are housed in an elongated hand-holdable tubular sleeve, the sleeve having upper and lower ends positioned along a longitudinal axis and the lower end being provided with a sampling head; in which: the supply tube is adapted to convey liquid from a liquid source to the sampling head; the recovery tube is adapted to convey liquid from the sampling head to a liquid collection vessel; the sampling head has a planar surface adapted for application to the surface of the skin to form a contact therewith during sampling; the planar surface has a liquid entry port adapted for liquid communication with the supply tube and a liquid exit port adapted for liquid communication with the recovery tube; and characterized in that: the liquid entry port and the liquid exit port are connected via a guide channel which is adapted to guide liquid from the liquid entry port, along the surface of the skin for the elution of mate

Abstract: An electroluminescent device described herein, in one aspect, comprises a first electrode and second electrode and a light emitting layer positioned between the first and second electrodes. A current injection gate is positioned between the first electrode and the light emitting layer or the second electrode and the light emitting layer. In some embodiments, the current injection gate comprises a semiconductor layer of electronic structure restricting injected current flow from the first or second electrode through the semiconductor layer as a function of alternating current voltage frequency applied to the first and second electrodes.

Abstract: An interchangeable lamp shade including an upper rigid frame. An interchangeable cover can be disposed on the upper rigid frame, the interchangeable cover having a sidewall and an upper end having an upper perimeter. An upper resilient band can be positioned on the cover and can extend along the upper perimeter of the cover. The upper rigid frame can be positioned between the upper resilient band and the sidewall of the cover, the upper resilient band resistant to twisting away from the upper rigid frame to retain the upper rigid frame between the upper resilient band and the sidewall of the cover. A method of assembling an interchangeable lamp shade of the present disclosure.

Abstract: An interchangeable lamp shade including an upper rigid frame. An interchangeable cover can be disposed on the upper rigid frame, the interchangeable cover having a sidewall and an upper end having an upper perimeter. An upper resilient band can be positioned on the cover and can extend along the upper perimeter of the cover. The upper rigid frame can be positioned between the upper resilient band and the sidewall of the cover, the upper resilient band resistant to twisting away from the upper rigid frame to retain the upper rigid frame between the upper resilient band and the sidewall of the cover. A method of assembling an interchangeable lamp shade of the present disclosure.

Abstract: Disclosed are sulfonamidoquinoline compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein R1, R2, R3 and R4 are as described herein. In certain embodiments, a compound disclosed herein inhibits ubiquitination, and can be used to treat disease by blocking the degradation of tumor suppressors.

Abstract: An electroluminescent device described herein, in one aspect, comprises a first electrode and second electrode and a light emitting layer positioned between the first and second electrodes. A current injection gate is positioned between the first electrode and the light emitting layer or the second electrode and the light emitting layer. In some embodiments, the current injection gate comprises a semiconductor layer of electronic structure restricting injected current flow from the first or second electrode through the semiconductor layer as a function of alternating current voltage frequency applied to the first and second electrodes.

Abstract: In one aspect, composite materials including a thin-film layer of lateral p-n junctions are described herein, which can be employed in circuits or various components of electrical devices. Briefly, a composite material comprises a thin-film layer including p-type regions alternating with n-type regions along a face of the thin-film layer, the p-type regions comprising electrically conductive particles dispersed in a first organic carrier and the n-type regions comprising electrically conductive particles dispersed in a second organic carrier, wherein p-n junctions are established at interfaces between the p-type and n-type regions. As described further herein, the thin-film layer is flexible, permitting the thin-film to be folded or arranged into a number of configurations to provide various circuits or components of electrical devices.