Abstract: Systems and methods are described for cataract intervention. In one embodiment a system comprises a laser source configured to produce a treatment beam comprising a plurality of laser pulses; an integrated optical system comprising an imaging assembly operatively coupled to a treatment laser delivery assembly such that they share at least one common optical element, the integrated optical system being configured to acquire image information pertinent to one or more targeted tissue structures and direct the treatment beam in a 3-dimensional pattern to cause breakdown in at least one of the targeted tissue structures; and a controller operatively coupled to the laser source and integrated optical system, and configured to adjust the laser beam and treatment pattern based upon the image information, and distinguish two or more anatomical structures of the eye based at least in part upon a robust least squares fit analysis of the image information.

Abstract: Systems and methods are described for cataract intervention. In one embodiment a system comprises a laser source configured to produce a treatment beam comprising a plurality of laser pulses; an integrated optical system comprising an imaging assembly operatively coupled to a treatment laser delivery assembly such that they share at least one common optical element, the integrated optical system being configured to acquire image information pertinent to one or more targeted tissue structures and direct the treatment beam in a 3-dimensional pattern to cause breakdown in at least one of the targeted tissue structures; and a controller operatively coupled to the laser source and integrated optical system, and configured to adjust the laser beam and treatment pattern based upon the image information, and distinguish two or more anatomical structures of the eye based at least in part upon a robust least squares fit analysis of the image information.

Abstract: Systems and methods are described for cataract intervention. In one embodiment a system comprises a laser source configured to produce a treatment beam comprising a plurality of laser pulses; an integrated optical system comprising an imaging assembly operatively coupled to a treatment laser delivery assembly such that they share at least one common optical element, the integrated optical system being configured to acquire image information pertinent to one or more targeted tissue structures and direct the treatment beam in a 3-dimensional pattern to cause breakdown in at least one of the targeted tissue structures; and a controller operatively coupled to the laser source and integrated optical system, and configured to adjust the laser beam and treatment pattern based upon the image information, and distinguish two or more anatomical structures of the eye based at least in part upon a robust least squares fit analysis of the image information.

Abstract: Systems and methods are described for cataract intervention. In one embodiment a system comprises a laser source configured to produce a treatment beam comprising a plurality of laser pulses; an integrated optical system comprising an imaging assembly operatively coupled to a treatment laser delivery assembly such that they share at least one common optical element, the integrated optical system being configured to acquire image information pertinent to one or more targeted tissue structures and direct the treatment beam in a 3-dimensional pattern to cause breakdown in at least one of the targeted tissue structures; and a controller operatively coupled to the laser source and integrated optical system, and configured to adjust the laser beam and treatment pattern based upon the image information, and distinguish two or more anatomical structures of the eye based at least in part upon a robust least squares fit analysis of the image information.

Abstract: Systems and methods are described for cataract intervention. In one embodiment a system comprises a laser source configured to produce a treatment beam comprising a plurality of laser pulses; an integrated optical system comprising an imaging assembly operatively coupled to a treatment laser delivery assembly such that they share at least one common optical element, the integrated optical system being configured to acquire image information pertinent to one or more targeted tissue structures and direct the treatment beam in a 3-dimensional pattern to cause breakdown in at least one of the targeted tissue structures; and a controller operatively coupled to the laser source and integrated optical system, and configured to adjust the laser beam and treatment pattern based upon the image information, and distinguish two or more anatomical structures of the eye based at least in part upon a robust least squares fit analysis of the image information.

Abstract: A system and method of treating target tissue that includes generating a treatment beam of light using a light source, directing the treatment beam onto target tissue using an optical element, generating an image of the target tissue from light emanating from the target tissue using a plurality of optical elements, and translating the light source, the optical element and/or the plurality of optical elements relative to the target tissue (using a translation device) to simultaneously move the treatment beam along the target tissue and the field of view of the target tissue as defined by the plurality of optical elements. Control electronics control the translation device to cause the treatment beam to move along the target tissue in a predetermined pattern.

Abstract: A beam delivery system for treating target tissue that includes an input for receiving a light beam, a variable attenuator for providing variable attenuation of the light beam, a power and wavelength detection assembly, a spot size adjustment assembly, and a controller. The power and wavelength detection assembly measures the power level of the beam, and detects when unwanted wavelengths are present in the light beam. The spot size adjustment assembly selectively feeds the beam through different optical fibers to achieve different spot sizes of the beam. The controller controls the variable attenuator, the power and wavelength detection assembly, and the spot size adjustment assembly to achieve the desired power and wavelength, and beam spot size.

Abstract: Systems and methods are described for cataract intervention. In one embodiment a system comprises a laser source configured to produce a treatment beam comprising a plurality of laser pulses; an integrated optical system comprising an imaging assembly operatively coupled to a treatment laser delivery assembly such that they share at least one common optical element, the integrated optical system being configured to acquire image information pertinent to one or more targeted tissue structures and direct the treatment beam in a 3-dimensional pattern to cause breakdown in at least one of the targeted tissue structures; and a controller operatively coupled to the laser source and integrated optical system, and configured to adjust the laser beam and treatment pattern based upon the image information, and distinguish two or more anatomical structures of the eye based at least in part upon a robust least squares fit analysis of the image information.

Abstract: A method for delivering electromagnetic radiation onto tissue to be ‘treated with the radiation includes delivering the radiation onto the tissue in a treatment-spot having a polygonal shape such as a rectangle or a hexagon. The polygonal shape is selected such that a region of the tissue to be treated’ can be completely covered by a plurality of such shapes essentially without overlapping the shapes. The radiation to be delivered is passed through a lightguide having a cross-section of the polygonal shape. Radiation exiting the lightguide is projected onto the tissue via a plurality of optical elements to provide the treatment-spot.

Abstract: A beam delivery system for treating target tissue that includes an input for receiving a light beam, a variable attenuator for providing variable attenuation of the light beam, a power and wavelength detection assembly, a spot size adjustment assembly, and a controller. The power and wavelength detection assembly measures the power level of the beam, and detects when unwanted wavelengths are present in the light beam. The spot size adjustment assembly selectively feeds the beam through different optical fibers to achieve different spot sizes of the beam. The controller controls the variable attenuator, the power and wavelength detection assembly, and the spot size adjustment assembly to achieve the desired power and wavelength, and beam spot size.

Abstract: An optical device and method for varying an optical characteristic of an optical beam can include a plurality of optical fibers each having an input end, an output end, and a core, wherein each of the optical fibers has an effective area and a numerical aperture, and a beam-deviating component for moving at least one of the optical fiber input ends and the optical beam relative to each other such that the optical beam selectively enters the input ends one at a time and is transmitted out the output ends one at a time, wherein at least one of the effective areas and the numerical apertures varies among the plurality of optical fibers such that the optical beam transmitted out of the output ends has a varying optical characteristic.

Abstract: The present invention is directed to an optical grating sensor configured to detect a phase change in light passing though the system due to a binding event caused by an analyte. The grating sensor may include a light source that may be, for example, a coherent light source. The invention may also include a first diffraction grating having a first period. A micro-electrical mechanical system (MEMS) may be displaced from the first diffraction grating and may be configured to modulate the light received form the coherent light source. An analyte recognition material may be disposed on the surface of the first grating. A detector may be configured to receive light form the coherent light source after the light has been diffracted from the first diffraction grating and modulated by the MEMS. In another embodiment of the present invention, the grating sensor may be configured to operate in two modes. The first mode may be a mode the detect a phase change in the light due to a binding event.

Abstract: A method for delivering electromagnetic radiation onto tissue to be ‘treated with the radiation includes delivering the radiation onto the tissue in a treatment-spot having a polygonal shape such as a rectangle or a hexagon. The polygonal shape is selected such that a region of the tissue to be treated’ can be completely covered by a plurality of such shapes essentially without overlapping the shapes. The radiation to be delivered is passed through a lightguide having a cross-section of the polygonal shape. Radiation exiting the lightguide is projected onto the tissue via a plurality of optical elements to provide the treatment-spot.

Abstract: The present invention is directed to an optical grating sensor configured to detect a phase change in light passing though the system due to a binding event caused by an analyte. The grating sensor may include a light source that may be, for example, a coherent light source. The invention may also include a first diffraction grating having a first period. A micro-electrical mechanical system (MEMS) may be displaced from the first diffraction grating and may be configured to modulate the light received form the coherent light source. An analyte recognition material may be disposed on the surface of the first grating. A detector may be configured to receive light form the coherent light source after the light has been diffracted from the first diffraction grating and modulated by the MEMS. In another embodiment of the present invention, the grating sensor may be configured to operate in two modes. The first mode may be a mode the detect a phase change in the light due to a binding event.

Abstract: A method for delivering electromagnetic radiation onto tissue to be treated with the radiation includes delivering the radiation onto the tissue in a treatment-spot having a polygonal shape such as a rectangle or a hexagon. The polygonal shape is selected such that a region of the tissue to be treated can be completely covered by a plurality of such shapes essentially without overlapping the shapes. The radiation to be delivered is passed through a lightguide having a cross-section of the polygonal shape. Radiation exiting the lightguide is projected onto the tissue via a plurality of optical elements to provide the treatment-spot.

Abstract: An apparatus and method may provide uniform illumination on the retina using scanned continuous wave laser sources by making use of waveguides with regular shaped cross sections. Some embodiments of the present invention may provide illumination uniformity for selected spots and/or whole target scans, and may provide for constant dwell times every point of the scanned beam. Furthermore, the non-uniformities caused by starting and stopping scans may be eliminated by, for example, clipping-off both the beginning and end of the scan with a hard aperture. A modulator may be provided, enabling uniform irradiation of selected target areas.

Abstract: A scanning optical system for delivering electromagnetic radiation onto tissue to be treated is cooperative with a lightguide or optical fiber. Radiation to be delivered is provided by a source thereof via the optical fiber. The optical system includes an optical projection arrangement comprising a plurality of lenses cooperatively arranged with the lightguide. A first of the lenses is arranged to receive radiation emerging from the lightguide. The beam of radiation is passed through the projection arrangement to form a treatment spot the radiation on the tissue. Scanning is effected by causing relative motion between the exit-end of said lightguide and at least the first lens, transverse to the optical axis of the projection arrangement. The treatment spot undergoes a related transverse motion over the tissue. In one example scanning is effected by moving the first lens with the lightguide fixed. The first lens is moved using an arrangement of piezo-electric actuators.

Abstract: A method for delivering electromagnetic radiation onto tissue to be treated with the radiation includes delivering the radiation onto the tissue in a treatment-spot having a polygonal shape such as a rectangle or a hexagon. The polygonal shape is selected such that a region of the tissue to be treated can be completely covered by a plurality of such shapes essentially without overlapping the shapes. The radiation to be delivered is passed through a lightguide having a cross-section of the polygonal shape. Radiation exiting the lightguide is projected onto the tissue via a plurality of optical elements to provide the treatment-spot.

Abstract: A method for delivering electromagnetic radiation onto tissue to be treated with the radiation includes delivering the radiation onto the tissue in a treatment-spot having a polygonal shape such as a rectangle or a hexagon. The polygonal shape is selected such that a region of the tissue to be treated can be completely covered by a plurality of such shapes essentially without overlapping the shapes. The radiation to be delivered is passed through a lightguide having a cross-section of the polygonal shape. Radiation exiting the lightguide is projected onto the tissue via a plurality of optical elements to provide the treatment-spot.

Abstract: An apparatus and method may provide uniform illumination on the retina using scanned continuous wave laser sources by making use of waveguides with regular shaped cross sections. Some embodiments of the present invention may provide illumination uniformity for selected spots and/or whole target scans, and may provide for constant dwell times every point of the scanned beam. Furthermore, the non-uniformities caused by starting and stopping scans may be eliminated by, for example, clipping-off both the beginning and end of the scan with a hard aperture. A modulator may be provided, enabling uniform irradiation of selected target areas.