Abstract: The invention relates to a system for the propagation of yeast and adaptation to ethanol in a sustained manner using a bioreactor (1) which is programmed automatically and in which the propagation and adaptation to ethanol, pH and temperature is carried out, for a secondary fermentation in the tirage of Cava, Champagne and sparkling wines in general. The bioreactor (1) includes a motor (6) with stirring blades, and a temperature-control system comprising a sleeve and an electrical resistor, said bioreactor (1) being associated with a mixing tank (2) which houses the liquor. In addition, a programmed pump (4) is provided between the bioreactor (1) and the mixing tank (2), as well as a programmable automaton with a control panel (5) for automating the process.

Abstract: Many computing systems process data organized in a matrix format. For example, artificial neural networks (ANNs) perform numerous computations on data organized into matrices using conventional matrix arithmetic operations. One such operation, which is commonly performed, is the transpose operation. Additionally, many such systems need to process many matrices and/or matrices that are large in size. For sparse matrices that hold few significant values and many values that can be ignored, transmitting and processing all the values in such matrices is wasteful. Thus, techniques are introduced for storing a sparse matrix in a compressed format that allows for a matrix transpose operation to be performed on the compressed matrix without having to first decompress the compressed matrix. By utilizing the introduced techniques, more matrix operations can be performed than conventional systems.

Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.

Abstract: A system includes credit network computing device(s) coupled to wallet provider computing device(s) and credit exchange computing device(s). Wallet provider computing device(s) receives credit request for loan having credit terms from borrower; generates smart contract including information regarding borrower and credit terms; and communicates smart contract to credit network computing device(s). Credit network computing device(s) receives indication that cosigner agrees to cosign for credit request on behalf of borrower; and communicates smart contract representing credit requests to credit exchange computing device(s). Credit exchange computing device(s) places smart contract representing credit request on order book. Credit exchange computing device(s) receives trading order for smart contract representing credit request from lender.

Abstract: The present invention provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The invention also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds.

Abstract: A method and system for generating a personalized health management recommendation for a user. During operation, the system obtains first physiological data generated by a wearable device worn by the user that indicates a physiological condition of the user. The system then generates a prediction model for the user based on the first physiological data. Next, the system obtains real-time physiological data generated by the wearable device. The system may generate a prediction by analyzing the real-time physiological data to determine whether the user's physiological condition exceeds a threshold parameter according to the prediction model. Upon determining that the threshold parameter has been exceeded, the system may select a recommendation and send the recommendation message to the user's mobile device.

Abstract: Systems, devices, and methods for controlling access to a medical device are provided. One example system includes an access card configured to wirelessly transmit user identification information and a medical device configured to receive the user identification information from the access card, and enable access to one or more components of the medical device based on permission information associated with the received user identification information. One example medical device includes a plurality of device components; a data receiver configured to wirelessly receive user identification information; a memory configured to store permission information in association with the user identification information; and a processor configured to retrieve the permission information from the memory in response to receiving the user identification information from the data receiver, and enable access to the one or more device components based on the retrieved permission information.

Abstract: A working machine has a body and a moveable element. The moveable element is moveable relative to the body. A camera captures an image of at least a portion of the moveable element. A processor executes a machine learning algorithm trained to determine a position of a moveable element from an image of the moveable element. The machine learning algorithm receives the image from the camera and determines the position of the moveable element in the image.

Abstract: A method for manufacturing electrically conductive structures, preferably conductive pathway structures using laser beams on a non-conductive carrier (LDS method), wherein a non-conductive carrier material is provided which contains at least one inorganic metal phosphate compound and at least one stabiliser finely distributed or dissolved therein, the carrier material is irradiated in regions by laser beams generating the electrically conductive structures in the irradiated regions.

Abstract: The present invention provides engineered phenylalanine ammonia lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia lyase (PAL) polypeptides. Methods for producing PAL enzymes are also provided. In some embodiments, the engineered PAL polypeptides are optimized to provide enhanced catalytic activities that are useful under industrial process conditions for the production of pharmaceutical compounds.

Abstract: A bag for medical use having three compartments, and having a compartment containing a solvent, a compartment containing a solute and a compartment containing a solvent, the compartment containing a solute being separated from the other two compartments by pincers, the opening of which allows liquid to flow by gravity, and, during opening of one of the pincers and under the effect of a pressure, the liquid contained in one compartment is propelled towards another compartment. A method for using a bag for medical use having three compartments is also provided.

Abstract: A joystick assembly for a working machine having a working arm includes a controller configured to control a plurality of machine functions, a first electronic joystick in communication with the controller, and actuators in communication with the controller. Each actuator is configured to actuate a function associated with the working arm. The first electronic joystick comprises four axes of movement, and the first electronic joystick is configured to transmit electronic signals to the controller in response to being displaced along an axis from a neutral position. The controller is configured to receive the electronic signals from the first electronic joystick, and to transmit an electrical signal to one or more actuators to actuate the actuators. The joystick assembly is configured such that the controller actuates a different actuator for controlling a different function associated with the working arm, dependent upon the axis of displacement of the first electronic joystick.

Abstract: Systems, devices, and methods for controlling access to a medical device are provided. One example system includes an access card configured to wirelessly transmit user identification information and a medical device configured to receive the user identification information from the access card, and enable access to one or more components of the medical device based on permission information associated with the received user identification information. One example medical device includes a plurality of device components; a data receiver configured to wirelessly receive user identification information; a memory configured to store permission information in association with the user identification information; and a processor configured to retrieve the permission information from the memory in response to receiving the user identification information from the data receiver, and enable access to the one or more device components based on the retrieved permission information.

Abstract: The present invention relates to the use of Lactobacillus rhamnosus in combination with Bifidobacterium longum to manufacture a formulation to increase male fertility in a subject. In particular, said strains are the strains Lactobacillus rhamnosus CECT 8361 and Bifidobacterium longum CECT 7347. Additionally, the formulation comprising the said strains Lactobacillus rhamnosus CECT 8361 and Bifidobacterium longum CECT 7347 is also described.

Abstract: The present invention provides engineered ?-glucosidase (BGL) enzymes, polypeptides having BGL activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the enzymes, and methods of using the engineered BGL enzymes to make products with ?-glucose linkages.

Abstract: Systems, devices, and methods for controlling access to a medical device are provided. One example system includes an access card configured to wirelessly transmit user identification information and a medical device configured to receive the user identification information from the access card, and enable access to one or more components of the medical device based on permission information associated with the received user identification information. One example medical device includes a plurality of device components; a data receiver configured to wirelessly receive user identification information; a memory configured to store permission information in association with the user identification information; and a processor configured to retrieve the permission information from the memory in response to receiving the user identification information from the data receiver, and enable access to the one or more device components based on the retrieved permission information.

Abstract: The present invention relates to calpain inhibitors for use in the prevention and/or treatment of adverse ventricular remodelling. In particular, they are for use in the adverse ventricular remodelling accompanying a myocardial infarction or due to chronic hypertension. The invention also relates to particular compositions comprising these inhibitors.

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: Systems, devices, and methods for controlling access to a medical device are provided. One example system includes an access card configured to wirelessly transmit user identification information and a medical device configured to receive the user identification information from the access card, and enable access to one or more components of the medical device based on permission information associated with the received user identification information. One example medical device includes a plurality of device components; a data receiver configured to wirelessly receive user identification information; a memory configured to store permission information in association with the user identification information; and a processor configured to retrieve the permission information from the memory in response to receiving the user identification information from the data receiver, and enable access to the one or more device components based on the retrieved permission information.

Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.