Abstract: A therapeutic composition and a method for the treatment of the acute and/or chronic symptoms associated with the excessive ingestion or inhalation of alcohols, most particularly ethanol in the form of alcoholic beverages. The therapeutic composition comprises an analgesic, nicotinamide and/or NAD, the nicotinamide and/or NAD being present in an amount of at least 7% by weight of the analgesic. The composition can further comprise additional water-soluble vitamins, and antacid component, an electrolyte salt replacement component, trace metal ions, and antihistaminic component, fructose, an alkaloid component and usual additives like sweetening agents, effervescent components, carriers, fillers, coloring agents, a.s.o. The composition is administered in a single dose either before going to sleep or the morning after.