Patents by Inventor David H. MacLennan

David H. MacLennan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosis for porcine malignant hyperthermia
    Patent number: 6001976
    Abstract: A purified DNA molecule comprises a DNA sequence of approximately 15.1 kb coding for normal or mutant RYR1 protein having a molecular weight of approximately 564,740 daltons. The DNA molecule has an endonuclease restriction map of FIG. 1 and a sequence of FIG. 2.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: December 14, 1999
    Assignee: University of Toronto Innovations Foundation and University of Guelph
    Inventors: David H. MacLennan, Peter J. O'Brien
  • Diagnosis for malignant hyperthermia
    Patent number: 5413907
    Abstract: A method for isolating a cDNA specific for the human ryanodine receptor is disclosed. The gene is associated with malignant hyperthermia, a hypermetabolic syndrome triggered primarily by inhalation anesthetics. The cDNA can be cloned and expressed in a recombinant plasmid or phage. The cDNA, or fragments thereof, is used as diagnostic probes for individuals at risk for malignant hyperthermia using restriction fragment length polymorphism analysis. The cDNA is that sequenced in FIG. 2 of this specification.
    Type: Grant
    Filed: April 13, 1992
    Date of Patent: May 9, 1995
    Assignees: The University of Toronto Innovations Foundation, HSC Research and Development Limited Partnership, The Toronto Hospital
    Inventors: Ronald G. Worton, David H. MacLennan, Beverley A. Britt
  • Diagnosis for porcine malignant hyperthermia
    Patent number: 5358649
    Abstract: A purified DNA molecule comprises a DNA sequence of approximately 15.1 kb coding for normal or mutant RYR1 protein having a molecular weight of approximately 564,740 daltons. The DNA molecule has an endonuclease restriction map of FIG. 1 and a sequence of FIG. 2.
    Type: Grant
    Filed: March 15, 1993
    Date of Patent: October 25, 1994
    Assignees: University of Guelph, The University of Toronto Innovations Foundation
    Inventors: David H. MacLennan, Peter J. O'Brien