Patents by Inventor David-Huy Nhu Nguyen

David-Huy Nhu Nguyen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220017882
    Abstract: The disclosure provides compositions and methods for modifying a target nucleic acid. In some embodiments, a composition can include a targetable nuclease, a DNA-binding protein, and a donor template comprising a homology directed repair (HDR) template and one or more DNA-binding protein target sequences. In some embodiments, a composition can include a Cas protein, one or more single guide RNAs (sgRNAs), and an anionic polymer.
    Type: Application
    Filed: December 12, 2019
    Publication date: January 20, 2022
    Inventors: Alexander Marson, Theodore Lee Roth, Daniel Goodman, David-Huy Nhu Nguyen, Francis C. Szoka
  • Publication number: 20120009222
    Abstract: The present invention provides lipidoids that can be used to modulate the immune response in a subject. Lipidoids are prepared by the conjugate addition of an amine to an acrylate to acrylamide. The lipidoids form complexes or particles with an immunostimulatory polynucleotide, which are then administerd to a subject. Such compositions have been found to stimulate the production of cytokines and increase both humoral and cell-mediate immune response. The invention also provides pharmaceuti-cal compositions thereof and methods for using the same.
    Type: Application
    Filed: October 27, 2009
    Publication date: January 12, 2012
    Applicant: Massachusetts Institute of Technology
    Inventors: David-Huy Nhu Nguyen, Daniel Griffith Anderson, Robert S. Langer, Kerry Peter Mahon