Patents by Inventor David K. Williams

David K. Williams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210070698
    Abstract: The present invention provides a compound of formula (II): an inhibitor of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases. Its prodrugs are disclosed.
    Type: Application
    Filed: January 3, 2019
    Publication date: March 11, 2021
    Inventors: James Aaron BALOG, Steven P. SEITZ, David K. WILLIAMS, Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH
  • Patent number: 10895111
    Abstract: A guide for a top drive unit includes a lower track member connected to a lower mast section and an upper track member connected to an upper mast section and telescoped with the lower track section. A slider is slidably positioned about the upper track member so the slider is movable along the upper track member. The slider has a lateral cross-sectional profile substantially the same size and shape as a lateral cross-sectional profile of the lower track member. The skate is slidably positioned about the lower track member to be movable along the lower track member and onto the slider. The skate travels along the upper track member via the slider. The skate is connectable to a top drive unit so the top drive unit is movable along the lower track member and the upper track member.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: January 19, 2021
    Assignee: Gordon Bros. Supply, Inc.
    Inventors: Robert L. Gordon, Ronald K. Gillespie, David L. Williams, James T. Grammer, Bobby D. Fisk, Charles W. Harjo
  • Publication number: 20210010328
    Abstract: A guide for a top drive unit includes a lower track member connected to a lower mast section and an upper track member connected to an upper mast section and telescoped with the lower track section. A slider is slidably positioned about the upper track member so the slider is movable along the upper track member. The slider has a lateral cross-sectional profile substantially the same size and shape as a lateral cross-sectional profile of the lower track member. The skate is slidably positioned about the lower track member to be movable along the lower track member and onto the slider. The skate travels along the upper track member via the slider. The skate is connectable to a top drive unit so the top drive unit is movable along the lower track member and the upper track member.
    Type: Application
    Filed: July 10, 2019
    Publication date: January 14, 2021
    Inventors: Robert L. Gordon, Ronald K. Gillespie, David L. Williams, James T. Grammer, Bobby D. Fisk, Charles W. Harjo
  • Publication number: 20200385541
    Abstract: Blends, polyol premix compositions, methods of forming such compositions, foamable compositions using the premix compositions, methods of preparing foams containing the premix compositions, and foams made using the premix compositions are described. The polyol premix composition includes a polyester polyol; halogenated olefin blowing agent; and a distribution-enhancing component. In the polyol premix composition, the blowing agent, the polyester polyol, and the distribution-enhancing component form a substantially uniform composition.
    Type: Application
    Filed: June 8, 2020
    Publication date: December 10, 2020
    Inventors: MARY C. BOGDAN, DAVID J. WILLIAMS, YIU K. LING, RONALD S. GROSSMAN, BIN YU
  • Publication number: 20200376209
    Abstract: A drive mechanism for a medicinal inhaler, the inhaler comprising: a patient port; a canister actuable by the drive mechanism to deliver a dose of medicament to the patient port, the drive mechanism comprising: a follower which moves between a first position in which the mechanism is primed for use and a second position in which the follower engages the canister to deliver a dose of medicament to the patient port, the follower being carried on a rocker plate which pivots as the follower moves between its first and second position, wherein the rocker plate engages a switch when the follower is in its second position to indicate that a dose of medicament has been delivered to the patient port.
    Type: Application
    Filed: April 24, 2018
    Publication date: December 3, 2020
    Inventors: Parfes Mohammed, Neale F. Griffiths, Jack L. Williams, Richard D. Brewer, Gary K. Jepps, Christopher Dawson, James L. Onslow, Christopher B.J. Groombridge, David M. Molony, Iain G. McDerment
  • Publication number: 20200359175
    Abstract: In some implementations, a first computing device can send notifications at times that the first computing device is not in an expected location. A user of a second computing device can remotely configure an expected location for the first computing device, which may be a particular location for a certain period of time. During that time, the first computing device can monitor its own location and check whether it is within the expected location. If the first computing device unexpectedly leaves or fails to enter the expected location, the first computing device may transmit a notification to the second computing device. Similarly, if the first computing device loses connectivity with other devices, a server device may notify the second computing device that the location of the first computing device cannot be determined.
    Type: Application
    Filed: April 10, 2020
    Publication date: November 12, 2020
    Applicant: Apple Inc.
    Inventors: Andreas E. Schobel, Swaminathan Jayaraman, Paul W. Salzman, Kevin M. Lynch, Tommy Rochette, Albert R. Howard, Siva Ganesh Movva, Thomas Chathoth Abraham, Frank De Jong, Rachel F. Needle, David John Williams, Raghunandan K. Pai, Swadesh Bhattacharya
  • Patent number: 10831318
    Abstract: A device includes an enclosure and logic. The enclosure includes a plurality of capacitive touch sensor arrays disposed at least on two of a top side, a bottom side, a left side, a right side, a front side, and a back side of the device. The enclosure also includes a first display on the front side of the device. The logic receives touch interaction information from the plurality of capacitive touch sensor arrays and initiates an action based at least in part on the touch interaction information.
    Type: Grant
    Filed: December 24, 2013
    Date of Patent: November 10, 2020
    Assignee: Intel Corporation
    Inventors: Min Liu, Lakshman Krishnamurthy, David L. Graumann, Jameson H. Williams, Miriam K. Selvaraj, Bryan R. Peebler, Wendy A. March, Brian K. Vogel, Wenbo Shen, Sihua Tian, Lijuan Xiao, Tao Wang, Xiaoyan Dang, Nithyananda S. Jeganathan, Sunil A. Kulkarni, Chan Wai Lee, Kaining Yuan
  • Patent number: 10829781
    Abstract: The invention relates to identifying and evaluating target coding sequences for control of plant parasitic nematodes by inhibiting one or more biological functions, and their use. The invention provides methods and compositions for identification of such sequences and for the control of a plant-parasitic nematode population. By feeding one or more recombinant double stranded RNA molecules provided by the invention to the nematode, a reduction in disease may be obtained through suppression of nematode gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and the plant cells and plants obtained thereby.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: November 10, 2020
    Assignee: Monsanto Technology LLC
    Inventors: Andrey A. Boukharov, Zijin Du, Liang Guo, Michelle C. Hresko, David K. Kovalic, Zhaolong Li, Maolong Lu, James P. McCarter, Nancy M. Miller, Mark Vaudin, Deryck J. Williams, Wei Wu
  • Patent number: 10801388
    Abstract: A heating apparatus and method for use in an exhaust gas system is provided that includes a container body defining an exhaust gas pathway, a heater flange component attached to an exterior of the container body, and a heater assembly disposed in the exhaust gas pathway and secured to the heater flange component. The heater assembly includes at least one heater element, a bracket assembly that secures the at least one heater element in the container body, and a conformal bracket for securing the at least one heater element to the bracket assembly.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: October 13, 2020
    Assignee: Watlow Electric Manufacturing Company
    Inventors: David P. Culbertson, Richard T. Williams, Jr., Christopher Meyers, Jeremy Ohse, Mark Everly, Roger Brummell, Gerald S. Jackson, Jake Spooler, James N. Pradun, Scott H. Boehmer, Mitchell T. Diaco, Robert K. Frake
  • Patent number: 10716919
    Abstract: A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: July 21, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Pu Zhou, Erik Bulman, Timothy A. Geiser, Michael G. Valdez, Yidong M. Zhu, Baigui Bian, Sonny Tran, Richard D. White, Thanh Huy Le, Tung T. Le, Alpana K. Gowdar, Yong Gao, David D. Williams
  • Patent number: 10696648
    Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: June 30, 2020
    Assignee: Bristol-Myers Squibb Company
    Inventors: David K. Williams, Weifang Shan, James Aaron Balog
  • Patent number: 10689331
    Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: June 23, 2020
    Assignee: Bristol-Myers Squibb Company
    Inventors: James Aaron Balog, Emily Charlotte Cherney, Jay A. Markwalder, Weifang Shan, David K. Williams
  • Publication number: 20200129500
    Abstract: The present invention provides compounds of Formula (I): (I) wherein all of the variables are as defined herein. These compounds are modulators of NLRP3, which may be used as medicaments for the treatment of proliferative disorders, such as cancer in a subject (e.g., a human).
    Type: Application
    Filed: July 12, 2018
    Publication date: April 30, 2020
    Inventors: Daniel O'Malley, Ashvinikumar V. Gavai, Patrice Gill, Christine M. Tarby, Scott Hunter Watterson, Hua Gong, David K. Williams, Shomir Ghosh, William R. Roush
  • Patent number: 10633342
    Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: April 28, 2020
    Assignee: Bristol-Myers Squibb Company
    Inventors: Emily Charlotte Cherney, Weifang Shan, Liping Zhang, David K. Williams, Weiwei Guo, Audris Huang, James Aaron Balog
  • Publication number: 20200095231
    Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
    Type: Application
    Filed: May 10, 2018
    Publication date: March 26, 2020
    Inventors: James Aaron BALOG, Emily Charlotte CHERNEY, Liping ZHANG, Audris HUANG, Weifang SHAN, David K. WILLIAMS, Xiao ZHU, Weiwei GUO
  • Patent number: 10576679
    Abstract: A vessel is configured to hold a product in an interior region formed in the vessel. The vessel includes an inner layer arranged to define the interior region and an outer layer. The vessel is formed using a blow-molding process in which a multiple layer parison is blow molded to form the vessel. The multiple layer parison is formed in an extrusion process in which a number of extruders are arranged to co-extrude associated inner and outer parisons to establish the multiple layer parison.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: March 3, 2020
    Assignee: Berry Plastics Corporation
    Inventors: David Dezhou Sun, Philip A. Driskill, Jeffrey C. Minnette, Birju A. Surti, Jonathan K. Williams
  • Patent number: 10544099
    Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: January 28, 2020
    Assignee: Bristol-Myers Squibb Company
    Inventors: Emily Charlotte Cherney, Liping Zhang, David K. Williams, James Aaron Balog
  • Patent number: 10537431
    Abstract: An expandable introducer sheath for passage of implant delivery catheters, such as catheters for delivery of prosthetic heart valves. The expandable sheath balances the amounts, shapes and positions of various stiff and elastic structures in the sheath to selectively program the expandability and buckling stiffness of the sheath. The expandable sheath can include, for example, an expandable tubular layer that includes alternating stiff and elastic wall portions of a single radial thickness. The combination of stiff and elastic wall portions allow for torque and push strength to advance the expandable sheath while at the same time accommodating temporary expansion. The expandable sheath can also be reinforced with a tubular layer of braided fibers or a stent structure for additional strength. Other embodiments include selective use of slots or gaps at the distal end of a stiff wall portion to enhance expandability and distribute strain.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: January 21, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Pu Zhou, Yong Gao, Erik Bulman, Baigui Bian, Yidong M. Zhu, David D. Williams, Timothy A. Geiser, Michael G. Valdez, Sonny Tran, Richard D. White, Thanh Huy Le, Tung T. Le, Alpana K. Gowdar
  • Patent number: 10533014
    Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: January 14, 2020
    Assignee: FLEXUS BIOSCIENCES, INC.
    Inventors: Hilary Plake Beck, Juan Carlos Jaen, Maksim Osipov, Jay Patrick Powers, Maureen Kay Reilly, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky, James Aaron Balog, David K. Williams, Jay A. Markwalder, Emily Charlotte Cherney, Weifang Shan, Audris Huang
  • Patent number: 10500377
    Abstract: A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: December 10, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: Pu Zhou, Erik Bulman, Timothy A. Geiser, Michael G. Valdez, Yidong M. Zhu, Baigui Bian, Sonny Tran, Richard D. White, Thanh Huy Le, Tung T. Le, Alpana K. Gowdar, Yong Gao, David D. Williams