Patents by Inventor David L. Kaplan

David L. Kaplan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10280204
    Abstract: A method of manufacturing a biopolymer optical device includes providing a polymer, providing a substrate, casting the polymer on the substrate, and enzymatically polymerizing an organic compound to generate a conducting polymer between the provided polymer and the substrate. The polymer may be a biopolymer such as silk and may be modified using organic compounds such as tyrosines to provide a molecular-level interface between the provided bulk biopolymer of the biopolymer optical device and a substrate or other conducting layer via a tyrosine-enzyme polymerization. The enzymatically polymerizing may include catalyzing the organic compound with peroxidase enzyme reactions. The result is a carbon-carbon conjugated backbone that provides polymeric “wires” for use in polymer and biopolymer optical devices. An all organic biopolymer electroactive material is thereby provided that provides optical functions and features.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: May 7, 2019
    Assignee: Tufts University
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Brian Lawrence, Mark Cronin-Golomb
  • Publication number: 20190105488
    Abstract: The present disclosure relates to programmable hydrogel ionic circuits having properties that are advantageous for use in biological systems. In particular, provided herein are programmable hydrogel ionic circuit that exhibit transparency, stretchability, aqueous-based connective interfaces, high-resolution routing of ionic currents between engineered and biological systems, and reduced tissue damage from electrochemical reactions. As described herein, the programmable hydrogel ionic circuits are produced using a combination of microfluidics and aqueous two-phase systems.
    Type: Application
    Filed: October 6, 2018
    Publication date: April 11, 2019
    Inventors: Siwei Zhao, Peter Tseng, Jonathan Grasman, Yu Wang, Fiorenzo G. Omenetto, David L. Kaplan
  • Publication number: 20190085140
    Abstract: Protein-protein imprinting of silk fibroin is introduced as a rapid, high-fidelity, and/or high-throughput method for the fabrication of nanoscale structures in silk films, through controlled manipulation of heat and/or pressure. High resolution imprinting on conformal surfaces is also demonstrated.
    Type: Application
    Filed: February 26, 2018
    Publication date: March 21, 2019
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Mark A. Brenckle
  • Publication number: 20190046647
    Abstract: Methods, compositions, devices and kits for increasing mechanical stiffness of an incompetent or a dilated biological tissue in a subject are provided herein. The methods described herein involve placing (e.g., injecting) a silk fibroin-based composition into at least a portion of an incompetent or dilated tissue of a subject. In some embodiments, the silk fibroin-based composition can further comprise at least two PEG components that will crosslink together upon placement (e.g., injection) into a subject in need thereof. In specific embodiments, the methods, compositions, devices and kits can be used to increase mechanical stiffness of a cervical tissue in a subject, for example, for treatment of cervical insufficiency.
    Type: Application
    Filed: March 7, 2018
    Publication date: February 14, 2019
    Inventors: Michael House, David L. Kaplan, Errol Norwitz, Simona Socrate
  • Publication number: 20190008923
    Abstract: The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
    Type: Application
    Filed: May 17, 2018
    Publication date: January 10, 2019
    Inventors: David L. Kaplan, Rina Sears, Gordana Vunjak-Novakovic, Lorenz Meinel
  • Publication number: 20190001272
    Abstract: The present disclosure provides, among other things, systems for processing silk. Provided systems purify silk fibroin solutions without inducing conformational changes in the silk proteins. Provided systems concentrate silk fibroin solutions. The present disclosure also provides methods of purifying and concentrating silk fibroin solutions. Provided systems and methods are useful for processing silk fibroin for any application.
    Type: Application
    Filed: December 16, 2016
    Publication date: January 3, 2019
    Inventors: Gary G. Leisk, David L. Kaplan, Benjamin P. Partlow, Tim Jia-Ching Lo
  • Publication number: 20180360947
    Abstract: Provided herein are methods and compositions for stabilization of active agents. The active agents are distributed, mixed or embedded in a silk fibroin matrix, thereby retaining the bioactivity of the active agents upon storage and/or transportation. In some embodiments, the storage-stable vaccine-silk compositions are also provided herein.
    Type: Application
    Filed: December 29, 2017
    Publication date: December 20, 2018
    Inventors: David L. Kaplan, Fiorenzo G. Omenetto
  • Publication number: 20180361015
    Abstract: In some embodiments, the present invention provides compositions including silk fibroin, at least one hydrophilic agent, and at least one catechol donating agent, wherein the at least one hydrophilic agent and at least one catechol donating agent are conjugated to the silk fibroin. According to various embodiments, at least a portion of the silk fibroin may be crosslinked. In some embodiments, the silk fibroin is at least 50% (e.g., 60%, 70%, 80%, 90%, 95% or more) crosslinked. In some embodiments, the present invention also provides methods for making such compositions.
    Type: Application
    Filed: November 29, 2016
    Publication date: December 20, 2018
    Inventors: Kelly A. Burke, David L. Kaplan
  • Publication number: 20180359850
    Abstract: Described herein are flexible and stretchable LED arrays and methods utilizing flexible and stretchable LED arrays. Assembly of flexible LED arrays alongside flexible plasmonic crystals is useful for construction of fluid monitors, permitting sensitive detection of fluid refractive index and composition. Co-integration of flexible LED arrays with flexible photodetector arrays is useful for construction of flexible proximity sensors. Application of stretchable LED arrays onto flexible threads as light emitting sutures provides novel means for performing radiation therapy on wounds.
    Type: Application
    Filed: March 30, 2018
    Publication date: December 13, 2018
    Inventors: John A. ROGERS, Rak-Hwan KIM, Dae-Hyeong KIM, David L. KAPLAN, Fiorenzo G. OMENETTO
  • Publication number: 20180339084
    Abstract: The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein are injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection) and/or be molded flexibly into a tissue void of any shape and/or size. In some embodiments, the composition described herein comprises a plurality of silk fibroin particles, which can retain their original volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.
    Type: Application
    Filed: February 20, 2018
    Publication date: November 29, 2018
    Inventors: Evangelia Bellas, Kacey Marra, J. Peter Rubin, David L. Kaplan, James J. Yoo
  • Publication number: 20180258389
    Abstract: In some embodiments, the present invention provides methods including the steps of providing one or more human somatic cells, causing transient increased expression of OCT4, KLF4, SOX2, and cMYC in the somatic cells forming modified somatic cells, providing a plurality of inactivated embryonic fibroblasts, associating the modified somatic cells with the inactivated embryonic fibroblasts in a culture media comprising 20% KO DMEM xeno-free serum replacement and at least 15 ng/ml recombinant bFGF to form human induced neural stem cells.
    Type: Application
    Filed: September 9, 2016
    Publication date: September 13, 2018
    Applicant: Trustees of Tufts College
    Inventors: Dana Cairns, David L. Kaplan
  • Publication number: 20180243479
    Abstract: The present invention provides, among other things, a silk ceramic material having enzymatically cross-linked amino acid side chains to generate injectable and flexible foam ceramics. Provided are compositions and methods of producing soft, flexible ceramic foam with silk polymeric crosslinking to serve as binders. Materials have applications in osteochondral and dental replacement and repair.
    Type: Application
    Filed: December 17, 2015
    Publication date: August 30, 2018
    Inventors: Stephanie L. McNamara, Benjamin P. Partlow, David L. Kaplan
  • Patent number: 10058514
    Abstract: The inventions provided herein relate to silk-based scaffolds and methods of producing the same, which can be used for a range of tissue engineering applications. The fabrication methods described herein provide a versatile platform to incorporate hollow conduits (e.g., for nutrient/oxygen delivery) through three-dimensional silk-based scaffolds that have tunable bulk properties (e.g., but not limited to, porosity, mechanical, degradation rate) and allow endothelialization and/or cell compartmentalization, for engineering a variety of complex tissue equivalents.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: August 28, 2018
    Assignee: TUFTS UNIVERSITY
    Inventors: Lindsay Wray, Jelena Rnjak-Kovacina, David L. Kaplan
  • Patent number: 10040834
    Abstract: A method of manufacturing a biopolymer optofluidic device including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the biopolymer matrix solution on the substrate, embedding a channel mold in the biopolymer matrix solution, drying the biopolymer matrix solution to solidify biopolymer optofluidic device, and extracting the embedded channel mold to provide a fluidic channel in the solidified biopolymer optofluidic device. In accordance with another aspect, an optofluidic device is provided that is made of a biopolymer and that has a channel therein for conveying fluid.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: August 7, 2018
    Assignee: TUFTS UNIVERSITY
    Inventors: Fiorenzo Omenetto, David L. Kaplan, Brian Lawrence, Mark Cronin-Golomb
  • Patent number: 10034945
    Abstract: The present disclosure relates generally to compositions and methods for production of three-dimensional constructs with high mechanical strength and/or stiffness.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: July 31, 2018
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Gary G. Leisk, Tim Jia-Ching Lo, Benjamin Partlow, Rosario Friedman
  • Patent number: 9993527
    Abstract: The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: June 12, 2018
    Assignees: TRUSTEES OF TUFTS COLLEGE, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: David L. Kaplan, Rina Sears, Gordana Vunjak-Novakovic, Lorenz Meinel
  • Patent number: 9986924
    Abstract: Provided herein are implantable biomedical devices and methods of administering implantable biomedical devices, making implantable biomedical devices, and using implantable biomedical devices to actuate a target tissue or sense a parameter associated with the target tissue in a biological environment.
    Type: Grant
    Filed: December 24, 2013
    Date of Patent: June 5, 2018
    Assignees: The Board of Trustees of the University of Illinois, Northwestern University, Trustees of Tufts College, The Trustees of the University of Pennsylvania
    Inventors: John A. Rogers, Dae-Hyeong Kim, Fiorenzo Omenetto, David L. Kaplan, Brian Litt, Jonathan Viventi, Yonggang Huang, Jason Amsden
  • Patent number: 9952148
    Abstract: In one aspect, the present invention generally provides methods for characterizing mineralization of a material, e.g., a biomaterial, by illuminating the material with radiation and analyzing radiation scattered from the material in response to the illumination. For example, in some embodiments, a material can be illuminated with polarized radiation at a plurality of wavelengths and the elastically scattered radiation corresponding to two or more of those wavelengths can be collected at two polarizations: one parallel and the other perpendicular to the illumination polarization. A differential intensity of the scattered radiation at the two polarizations can be analyzed as a function of wavelength to obtain information regarding the morphology of mineral deposits in the sample. Further, the total scattered radiation can be analyzed to derive information regarding the level of mineralization.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: April 24, 2018
    Assignee: Trustees of Tufts College
    Inventors: Irene Georgakoudi, Sharad Gupta, Martin Hunter, David L. Kaplan
  • Publication number: 20180098271
    Abstract: Systems and methods are described for a power aggregation system. In one implementation, a method includes charging an electric resource over a power connection to an electric network, obtaining a unique identifier of a device over the power connection, and determining an electric network location of the electric resource from the unique identifier.
    Type: Application
    Filed: April 14, 2017
    Publication date: April 5, 2018
    Applicant: V2Green, Inc.
    Inventors: Seth W. BRIDGES, Seth B. POLLACK, David L. KAPLAN
  • Patent number: 9931434
    Abstract: The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein are injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection) and/or be molded flexibly into a tissue void of any shape and/or size. In some embodiments, the composition described herein comprises a plurality of silk fibroin particles, which can retain their original volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: April 3, 2018
    Assignees: Trustees of Tufts College, University of Pittsburgh of the Commonwealth System of Higher Education, Wake Forest University Health Sciences
    Inventors: Evangelia Bellas, Kacey Marra, J. Peter Rubin, David L. Kaplan, James J. Yoo