Abstract: A surgical clip may include: a first leg member having an inner surface, an outer surface, and first and second side surfaces, the inner surface of the first leg member having a concave curvature; a second leg member having an inner surface, an outer surface, and first and second side surfaces, the inner surface of the second leg member having a convex curvature; at least one first tooth extending from a first lateral side of the inner surface of the second leg member; and a first channel defined between the first side surface and the inner surface of the first leg member. The first and second leg members may be configured to move between an open configuration and a closed configuration, and in the closed configuration, the at least one first tooth is received in the first channel.

Abstract: A surgical clip may include first and second leg members, each having inner surfaces. The inner surface of the first leg member may be concave and the inner surface of the second leg member may be convex. The surgical clip may include a first locking member positioned on a distal end portion of the first leg member, and a second locking member positioned on a distal end portion of the second leg member. The surgical clip may also include a third locking member position between a proximal end portion and the distal end portion of the first leg member, and a fourth locking member positioned between a proximal end portion and the distal end portion of the second leg member. The first and second locking members, and the third and fourth locking members may be configured to interact to secure the surgical clip in a closed configuration.

Abstract: A surgical clip may be configured to ligate tissue. The surgical clip may include first and second leg members. The first leg member may have a proximal portion, a distal portion, a convex first inner surface, and a convex first outer surface. The first leg member may also include an inner portion at least partially defining the first inner surface and an outer portion at least partially defining the first outer surface. The inner and outer portions may be joined at first and second portions of the first leg member and separated by a channel. The second leg member may include a proximal portion, a distal portion, a second inner surface, and a second outer surface. The first and second leg members may be movable relative to each other between open and closed configurations, and the first and second inner surfaces may be configured to ligate the tissue when in the closed configuration.

Abstract: A surgical clip may include first and second leg members, each having inner surfaces. The inner surface of the first leg member may be concave and the inner surface of the second leg member may be convex. The surgical clip may include a first locking member positioned on a distal end portion of the first leg member, and a second locking member positioned on a distal end portion of the second leg member. The surgical clip may also include a third locking member position between a proximal end portion and the distal end portion of the first leg member, and a fourth locking member positioned between a proximal end portion and the distal end portion of the second leg member. The first and second locking members, and the third and fourth locking members may be configured to interact to secure the surgical clip in a closed configuration.

Abstract: A surgical clip may be configured to ligate tissue. The surgical clip may include first and second leg members. The first leg member may have a proximal portion, a distal portion, a convex first inner surface, and a convex first outer surface. The first leg member may also include an inner portion at least partially defining the first inner surface and an outer portion at least partially defining the first outer surface. The inner and outer portions may be joined at first and second portions of the first leg member and separated by a channel. The second leg member may include a proximal portion, a distal portion, a second inner surface, and a second outer surface. The first and second leg members may be movable relative to each other between open and closed configurations, and the first and second inner surfaces may be configured to ligate the tissue when in the closed configuration.

Abstract: A safety vial system has a vial adapter subsystem irreversibly mountable to the top of a vial containing a hazardous medicament and a vial base subsystem sealingly engaging a lower portion of the vial adapter subsystem and telescopically movable therein from a first position providing a path for gas sterilization around the vial to a second position wherein the path is closed to form a sterilized expandable, neutral pressure bellows chamber around and below the vial. The device has a removable top cap, a pierceable barrier film, a normally closed needleless valve in fluid communication with a dual lumen spike initially disposed above the film and a frangible product integrity ring holding the activation housing in place for sealed telescopic movement on a main body that surrounds the vial.

Abstract: A surgical clip may include a first leg member having a first inner surface with a concave curvature, a second leg member having second inner surface with a convex curvature, and a hinge member pivotally coupling the first leg member and the second leg member. The first leg member may have a first thickness in a compression direction, a first width in a lateral direction, and a first length in a longitudinal direction. The second leg member may have a second thickness in the compression direction, a second width in the lateral direction, and a first length in the longitudinal direction. The first width may be greater than the first thickness along at least half of the first length, and/or the second width may be greater than the second thickness along gat least half of the second length.

Abstract: A surgical clip may include: a first leg member having an inner surface, an outer surface, and first and second side surfaces, the inner surface of the first leg member having a concave curvature; a second leg member having an inner surface, an outer surface, and first and second side surfaces, the inner surface of the second leg member having a convex curvature; at least one first tooth extending from a first lateral side of the inner surface of the second leg member; and a first channel defined between the first side surface and the inner surface of the first leg member. The first and second leg members may be configured to move between an open configuration and a closed configuration, and in the closed configuration, the at least one first tooth is received in the first channel.

Abstract: A surgical clip may include: a first leg member having an inner surface, an outer surface, and first and second side surfaces, the inner surface of the first leg member having a concave curvature; a second leg member having an inner surface, an outer surface, and first and second side surfaces, the inner surface of the second leg member having a convex curvature; at least one first tooth extending from a first lateral side of the inner surface of the second leg member; and a first channel defined between the first side surface and the inner surface of the first leg member. The first and second leg members may be configured to move between an open configuration and a closed configuration, and in the closed configuration, the at least one first tooth is received in the first channel.

Abstract: A method of securing a surgical clip to a clip applier may include engaging a first applier tip with a first jaw member, and engaging a second applier tip with a second jaw member. The jaw members may be secured within sleeve portions of the applier tips. The surgical clip may then be received between the first and second jaw members and secured with the first and second applier tips. The surgical clip may be secured to the clip applier by receiving a proximal portion of the surgical clip between a first protrusion of the first applier tip and a second protrusion of the second applier tip, receiving a first boss member on a first leg member of the surgical clip in a recess of the first applier tip, and receiving a second boss member on a second leg member of the surgical clip in a recess of the second applier tip.

Abstract: A clip applier may be configured to apply a surgical clip and have a pair of jaw members. Each of the jaw members may have an inner surface and a stabilizing member extending from the inner surface. Each of the jaw members may be configured to engage a distal portion of a leg member of the surgical clip. The stabilizing members may be configured to be positioned on opposite lateral sides of a proximal portion of the surgical clip to reduce lateral movement of the surgical clip. An inner portion of each of the stabilizing members may be spaced apart from the opposing jaw member in an open configuration, and each of the jaw members may have a channel on the inner surface to receive the opposing stabilizing member in a closed configuration.

Abstract: A surgical clip may include first and second leg members, each having inner surfaces. The inner surface of the first leg member may be concave and the inner surface of the second leg member may be convex. The surgical clip may include a first locking member positioned on a distal end portion of the first leg member, and a second locking member positioned on a distal end portion of the second leg member. The surgical clip may also include a third locking member position between a proximal end portion and the distal end portion of the first leg member, and a fourth locking member positioned between a proximal end portion and the distal end portion of the second leg member. The first and second locking members, and the third and fourth locking members may be configured to interact to secure the surgical clip in a closed configuration.

Abstract: A surgical clip may be configured to ligate tissue. The surgical clip may include first and second leg members. The first leg member may have a proximal portion, a distal portion, a convex first inner surface, and a convex first outer surface. The first leg member may also include an inner portion at least partially defining the first inner surface and an outer portion at least partially defining the first outer surface. The inner and outer portions may be joined at first and second portions of the first leg member and separated by a channel. The second leg member may include a proximal portion, a distal portion, a second inner surface, and a second outer surface. The first and second leg members may be movable relative to each other between open and closed configurations, and the first and second inner surfaces may be configured to ligate the tissue when in the closed configuration.

Abstract: A surgical clip may be configured to ligate tissue. The surgical clip may include first and second leg members. The first leg member may have a proximal portion, a distal portion, a convex first inner surface, and a convex first outer surface. The first leg member may also include an inner portion at least partially defining the first inner surface and an outer portion at least partially defining the first outer surface. The inner and outer portions may be joined at first and second portions of the first leg member and separated by a channel. The second leg member may include a proximal portion, a distal portion, a second inner surface, and a second outer surface. The first and second leg members may be movable relative to each other between open and closed configurations, and the first and second inner surfaces may be configured to ligate the tissue when in the closed configuration.

Abstract: A safety vial system has a vial adapter subsystem irreversibly mountable to the top of a vial containing a hazardous medicament and a vial base subsystem sealingly engaging a lower portion of the vial adapter subsystem and telescopically movable therein from a first position providing a path for gas sterilization around the vial to a second position wherein the path is closed to form a sterilized expandable, neutral pressure bellows chamber around and below the vial. The device has a removable top cap, a pierceable barrier film, a normally closed needleless valve in fluid communication with a dual lumen spike initially disposed above the film and a frangible product integrity ring holding the activation housing in place for sealed telescopic movement on a main body that surrounds the vial.

Abstract: A surgical clip may include: a first leg member having an inner surface, an outer surface, and first and second side surfaces, the inner surface of the first leg member having a concave curvature; a second leg member having an inner surface, an outer surface, and first and second side surfaces, the inner surface of the second leg member having a convex curvature; at least one first tooth extending from a first lateral side of the inner surface of the second leg member; and a first channel defined between the first side surface and the inner surface of the first leg member. The first and second leg members may be configured to move between an open configuration and a closed configuration, and in the closed configuration, the at least one first tooth is received in the first channel.

Abstract: A method of securing a surgical clip to a clip applier may include engaging a first applier tip with a first jaw member, and engaging a second applier tip with a second jaw member. The jaw members may be secured within sleeve portions of the applier tips. The surgical clip may then be received between the first and second jaw members and secured with the first and second applier tips. The surgical clip may be secured to the clip applier by receiving a proximal portion of the surgical clip between a first protrusion of the first applier tip and a second protrusion of the second applier tip, receiving a first boss member on a first leg member of the surgical clip in a recess of the first applier tip, and receiving a second boss member on a second leg member of the surgical clip in a recess of the second applier tip.

Abstract: A surgical clip may be configured to ligate tissue. The surgical clip may include first and second leg members. The first leg member may have a proximal portion, a distal portion, a convex first inner surface, and a convex first outer surface. The first leg member may also include an inner portion at least partially defining the first inner surface and an outer portion at least partially defining the first outer surface. The inner and outer portions may be joined at first and second portions of the first leg member and separated by a channel. The second leg member may include a proximal portion, a distal portion, a second inner surface, and a second outer surface. The first and second leg members may be movable relative to each other between open and closed configurations, and the first and second inner surfaces may be configured to ligate the tissue when in the closed configuration.