Patents by Inventor David Lutje Hulsik

David Lutje Hulsik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS COMPRISING ANTIBODIES THAT BIND GAMMA-DELTA T CELL RECEPTORS
    Publication number: 20250109204
    Abstract: The present invention relates to pharmaceutical compositions comprising antibodies capable of binding a human V?9V?2 T cell receptor. The invention further relates to uses of the pharmaceutical compositions of the invention for medical treatment.
    Type: Application
    Filed: December 13, 2024
    Publication date: April 3, 2025
    Inventors: Paul Willem Henri Ida PARREN, Robertus Cornelis ROOVERS, Johannes Jelle VAN DER VLIET, David LUTJE HULSIK, Peter Alexander Gerardus Maria MACHIELSEN, Michiel VAN WESTERHOVEN, Lisa Anna KING, Felix-Lennart FENNEMANN, Jochem Willem VAN DER VEEN
  • METHOD OF TREATING IGA NEPHROPATHY BY ADMINISTERING ALTERED ANTIBODIES WHICH BIND HUMAN A PROLIFERATION-INDUCING LIGAND (APRIL) PROTEIN
    Publication number: 20250101121
    Abstract: The invention relates to APRIL-binding antibodies, which bind the same epitope of human APRIL as an antibody having an antigen binding site of hAPRIL.01A. The antibodies of the present invention comprise specific selections of framework sequences of the VH and VL domains and have unexpected features in comparison to hAPRIL.01A. The invention further relates to compositions comprising an antibody of the invention and to the medical and diagnostic uses of the antibodies and compositions.
    Type: Application
    Filed: October 9, 2024
    Publication date: March 27, 2025
    Inventors: Hans Van Eenennaam, Andrea van Elsas, David Lutje Hulsik, Jan Paul Medema
  • Method of treating IgA nephropathy by administering altered antibodies which bind human a proliferation-inducing ligand (APRIL) protein
    Patent number: 12145992
    Abstract: The invention relates to APRIL-binding antibodies, which bind the same epitope of human APRIL as an antibody having an antigen binding site of hAPRIL.01A. The antibodies of the present invention comprise specific selections of framework sequences of the VH and VL domains and have unexpected features in comparison to hAPRIL.01A. The invention further relates to compositions comprising an antibody of the invention and to the medical and diagnostic uses of the antibodies and compositions.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: November 19, 2024
    Assignee: ADURO BIOTECH HOLDINGS, EUROPE B.V.
    Inventors: Hans Van Eenennaam, Andrea van Elsas, David Lutje Hulsik, Jan Paul Medema
  • ANTIBODIES THAT BIND PSMA AND GAMMA-DELTA T CELL RECEPTORS
    Publication number: 20240317888
    Abstract: The present invention relates to antibodies capable of binding human PSMA and capable of binding a human V?9V?2 T cell receptor. The invention further relates to pharmaceutical compositions comprising the antibodies of the invention and to uses of the antibodies of the invention for medical treatment.
    Type: Application
    Filed: May 6, 2024
    Publication date: September 26, 2024
    Inventors: Robertus Cornelis ROOVERS, Johannes Jelle VAN DER VLIET, Lisa Anna KING, Paul Willem Henri Ida PARREN, Victoria IGLESIAS GUIMARAIS, David LUTJE HULSIK, Peter Alexander Gerardus Maria MACHIELSEN
  • ANTIBODIES THAT BIND CD123 AND GAMMA-DELTA T CELL RECEPTORS
    Publication number: 20240141071
    Abstract: The present invention relates to antibodies capable of binding human CD123 and capable of binding the V?2 chain of a human V?9V?2 T cell receptor. The invention further relates to pharmaceutical compositions comprising the antibodies of the invention and to uses of the antibodies of the invention for medical treatment.
    Type: Application
    Filed: February 28, 2022
    Publication date: May 2, 2024
    Inventors: Robertus Cornelis ROOVERS, Johannes Jelle VAN DER VLIET, David LUTJE HULSIK, Paul Willem Henri Ida PARREN, Jurjen Matthijs RUBEN, Charlotte Merette MOUSSET
  • ANTIBODIES THAT BIND GAMMA-DELTA T CELL RECEPTORS
    Publication number: 20230303694
    Abstract: The present invention relates to antibodies capable of binding a human V?9V?d2 T cell receptor. The invention further relates to pharmaceutical compositions comprising the antibodies of the invention and to uses of the antibodies of the invention for medical treatment.
    Type: Application
    Filed: June 9, 2023
    Publication date: September 28, 2023
    Inventors: Paul Willem Henri Ida PARREN, Robertus Cornelis ROOVERS, Johannes Jelle VAN DER VLIET, David LUTJE HULSIK, Peter Alexander Gerardus Maria MACHIELSEN, Michiel VAN WESTERHOVEN, Lisa Anna KING, Felix-Lennart FENNEMANN
  • ANTIBODIES THAT BIND PSMA AND GAMMA-DELTA T CELL RECEPTORS
    Publication number: 20230272110
    Abstract: Provided herein are antibodies capable of binding human PSMA and capable of binding a human V?9V?2 T cell receptor. In particular, provided herein are pharmaceutical compositions comprising the antibodies capable of binding human PSMA and capable of binding a human V?9V? T cell receptor and uses of the antibodies for medical treatment.
    Type: Application
    Filed: July 8, 2021
    Publication date: August 31, 2023
    Inventors: Robertus Cornelis Roovers, Johannes Jelle VAN DER VLIET, Lisa Anna KING, Paul Willem Henri Ida PARREN, Victoria IGLESIAS GUIMARAIS, David LUTJE HULSIK, Peter Alexander Gerardus Maria MACHIELSEN
  • ANTI-SIRP ALPHA ANTIBODIES
    Publication number: 20220135671
    Abstract: The present invention relates to anti-SIRP? antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease.
    Type: Application
    Filed: November 30, 2020
    Publication date: May 5, 2022
    Applicant: ADURO BIOTECH HOLDINGS, EUROPE B.V.
    Inventors: Hans VAN EENENNAAM, Andrea VAN ELSAS, Erik VOETS, Paul VINK, David Lutje HULSIK
  • ANTI-SIRP ALPHA ANTIBODIES
    Publication number: 20220135677
    Abstract: The present invention relates to anti-SIRP? antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease.
    Type: Application
    Filed: January 14, 2022
    Publication date: May 5, 2022
    Applicant: SAIROPA B.V.
    Inventors: Hans VAN EENENNAAM, Andrea VAN ELSAS, Erik VOETS, Paul VINK, David Lutje HULSIK
  • ALTERED APRIL BINDING ANTIBODIES
    Publication number: 20210221900
    Abstract: The invention relates to APRIL-binding antibodies, which bind the same epitope of human APRIL as an antibody having an antigen binding site of hAPRIL.01A. The antibodies of the present invention comprise specific selections of framework sequences of the VH and VL domains and have unexpected features in comparison to hAPRIL.01A. The invention further relates to compositions comprising an antibody of the invention and to the medical and diagnostic uses of the antibodies and compositions.
    Type: Application
    Filed: March 29, 2021
    Publication date: July 22, 2021
    Applicant: ADURO BIOTECH HOLDINGS, EUROPE B.V.
    Inventors: Hans Van Eenennaam, Andrea van Elsas, David Lutje Hulsik, Jan Paul Medema
  • Humanized antibodies which bind to human APRIL (“a proliferation-inducing ligand”)
    Patent number: 10961316
    Abstract: The invention relates to APRIL-binding antibodies, which bind the same epitope of human APRIL as an antibody having an antigen binding site of hAPRIL.01A. The antibodies of the present invention comprise specific selections of framework sequences of the VH and VL domains and have unexpected features in comparison to hAPRIL.01A. The invention further relates to compositions comprising an antibody of the invention and to the medical and diagnostic uses of the antibodies and compositions.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: March 30, 2021
    Assignee: ADURO BIOTECH HOLDINGS, EUROPE B.V.
    Inventors: Hans van Eenennaam, Andrea van Elsas, David Lutje Hulsik, Jan Paul Medema
  • Anti-SIRP? antibodies
    Patent number: 10851164
    Abstract: The present invention relates to anti-SIRP? antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: December 1, 2020
    Assignee: ADURO BIOTECH HOLDINGS, EUROPE B.V.
    Inventors: Hans Van Eenennaam, Andrea Van Elsas, Erik Voets, Paul Vink, David Lutje Hulsik
  • Anti-HCTLA-4 antibodies
    Patent number: 10808030
    Abstract: The invention relates to new anti-hCTLA-4 antibodies that bind to a different epitope than prior art anti-CTLA4 antibodies, methods to produce these antibodies and therapeutic and diagnostic uses of these antibodies. These antibodies show a similar affinity for the CTLA4 antigen and they are also able to block the binding of CTLA4 to CD80 and/or CD86.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: October 20, 2020
    Assignee: ADURO BIOTECH HOLDINGS, EUROPE B.V.
    Inventors: Hans Van Eenennaam, Andrea Van Elsas, Joost Kreijtz, David Lutje Hulsik, Paul Vink
  • ALTERED APRIL BINDING ANTIBODIES
    Publication number: 20200079859
    Abstract: The invention relates to APRIL-binding antibodies, which bind the same epitope of human APRIL as an antibody having an antigen binding site of hAPRIL.01A. The antibodies of the present invention comprise specific selections of framework sequences of the VH and VL domains and have unexpected features in comparison to hAPRIL.01A. The invention further relates to compositions comprising an antibody of the invention and to the medical and diagnostic uses of the antibodies and compositions.
    Type: Application
    Filed: August 12, 2019
    Publication date: March 12, 2020
    Applicant: ADURO BIOTECH HOLDINGS, EUROPE B.V.
    Inventors: Hans van Eenennaam, Andrea van Elsas, David Lutje Hulsik, Jan Paul Medema
  • Anti-PD-1 antibodies
    Patent number: 10494436
    Abstract: The present invention relates to anti-PD-1 antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease. These antibodies have CDRs as provided in the enclosed sequences. Also part of the invention are nucleic acids encoding these antibodies, expression vectors comprising such nucleotide sequences and host cells that comprise said nucleotide sequences or expression vectors.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: December 3, 2019
    Assignee: ADURO BIOTECH HOLDINGS, EUROPE B.V.
    Inventors: Hans Van Eenennaam, Andrea Van Elsas, Joost Kreijtz, David Lutje Hulsik, Carlos Ricardo Rodrigues Dos Reis
  • Method of treating IgA nephropathy by administering humanized APRIL-binding antibodies
    Patent number: 10377830
    Abstract: The invention relates to APRIL-binding antibodies, which bind the same epitope of human APRIL as an antibody having an antigen binding site of hAPRIL.01A. The antibodies of the present invention comprise specific selections of framework sequences of the VH and VL domains and have unexpected features in comparison to hAPRIL.01A. The invention further relates to compositions comprising an antibody of the invention and to the medical and diagnostic uses of the antibodies and compositions.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: August 13, 2019
    Assignee: ADURO BIOTECH HOLDINGS, EUROPE B.V.
    Inventors: Hans van Eenennaam, Andrea van Elsas, David Lutje Hulsik, Jan Paul Medema
  • ANTI-SIRP ALPHA ANTIBODIES
    Publication number: 20180312587
    Abstract: The present invention relates to anti-SIRP antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease.
    Type: Application
    Filed: April 13, 2018
    Publication date: November 1, 2018
    Applicant: ADURO BIOTECH HOLDINGS, EUROPE B.V.
    Inventors: Hans VAN EENENNAAM, Andrea VAN ELSAS, Erik VOETS, Paul VINK, David Lutje HULSIK
  • ALTERED APRIL BINDING ANTIBODIES
    Publication number: 20180258176
    Abstract: The invention relates to APRIL-binding antibodies, which bind the same epitope of human APRIL as an antibody having an antigen binding site of hAPRIL.01A. The antibodies of the present invention comprise specific selections of framework sequences of the VH and VL domains and have unexpected features in comparison to hAPRIL.01A. The invention further relates to compositions comprising an antibody of the invention and to the medical and diagnostic uses of the antibodies and compositions.
    Type: Application
    Filed: May 14, 2018
    Publication date: September 13, 2018
    Applicant: ADURO BIOTECH HOLDINGS, EUROPE B.V.
    Inventors: Hans van Eenennaam, Andrea van Elsas, David Lutje Hulsik, Jan Paul Medema
  • Altered APRIL binding antibodies
    Patent number: 9969808
    Abstract: The invention relates to APRIL-binding antibodies, which bind the same epitope of human APRIL as an antibody having an antigen binding site of hAPRIL.01A. The antibodies of the present invention comprise specific selections of framework sequences of the VH and VL domains and have unexpected features in comparison to hAPRIL.01A. The invention further relates to compositions comprising an antibody of the invention and to the medical and diagnostic uses of the antibodies and compositions.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: May 15, 2018
    Assignee: ADURO BIOTECH HOLDINGS, EUROPE B.V.
    Inventors: Hans van Eenennaam, Andrea van Elsas, David Lutje Hulsik, Jan Paul Medema
  • NEW ANTI-HCTLA-4 ANTIBODIES
    Publication number: 20180037654
    Abstract: The invention relates to new anti-hCTLA-4 antibodies that bind to a different epitope than prior art anti-CTLA4 antibodies, methods to produce these antibodies and therapeutic and diagnostic uses of these antibodies. These antibodies show a similar affinity for the CTLA4 antigen and they are also able to block the binding of CTLA4 to CD80 and/or CD86.
    Type: Application
    Filed: October 2, 2017
    Publication date: February 8, 2018
    Applicant: ADURO BIOTECH HOLDINGS, EUROPE B.V.
    Inventors: Hans VAN EENENNAAM, Andrea VAN ELSAS, Joost KREIJTZ, David Lutje HULSIK, Paul VINK