Patents by Inventor David M. Kaye
David M. Kaye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11633538Abstract: A system for modulating delivery of a fluid medium includes an injector for injecting the fluid medium during an injection cycle, a delivery catheter including a conduit for delivering the fluid medium, a manifold disposed in a fluid medium flow path between the injector and the delivery catheter, and a pulsatile generator. The pulsatile generator is configured to apply a pulsatile force to the fluid medium defined by a plurality of duty cycles during the injection cycle, each of the duty cycles including a first pressure level and a second pressure level that is lower than the first pressure level.Type: GrantFiled: May 11, 2020Date of Patent: April 25, 2023Assignee: Osprey Medical, Inc.Inventors: Matthew M. Burns, Tuan M. Doan, Rodney L. Houfburg, David M. Kaye, Todd J. Mortier
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Patent number: 11623036Abstract: Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.Type: GrantFiled: November 11, 2019Date of Patent: April 11, 2023Assignee: Osprey Medical, Inc.Inventors: Matthew M. Burns, Tuan M. Doan, Rodney L. Houfburg, David M. Kaye, Daniel R. Mans, Todd J. Mortier
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Publication number: 20220211942Abstract: A system for delivering an amount of fluid medium includes an injector, a delivery catheter and a pulsatile generator. The injector is configured for injecting the fluid medium during an injection cycle. The delivery catheter includes a conduit for delivering the fluid medium. The pulsatile generator is configured to apply a pulsatile force on the fluid medium delivered through the delivery catheter at a pulsation frequency. The pulsatile force is defined by a plurality of duty cycles during the injection cycle, each of the plurality of duty cycles including a first flow level and a second flow level that is lower than the first flow level. The pulsation frequency is 3 or more duty cycles per second.Type: ApplicationFiled: February 11, 2022Publication date: July 7, 2022Inventors: Matthew M. Burns, Tuan M. Doan, Rodney L. Houfburg, David M. Kaye, Todd J. Mortier
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Patent number: 11235099Abstract: Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.Type: GrantFiled: May 21, 2019Date of Patent: February 1, 2022Assignee: Osprey Medical, Inc.Inventors: Matthew M. Burns, Tuan M. Doan, Rodney L. Houfburg, David M. Kaye, Daniel R. Mans, Todd J. Mortier
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Patent number: 10835670Abstract: Systems and methods for modulating delivery of a fluid medium to a selected site within a patient's body are described. A system includes a syringe for injecting the fluid medium, a delivery catheter including a conduit for delivering the fluid medium from outside of the body to the selected site within the body, a diversion reservoir configured to receive a portion of the fluid medium, and a flow diverter assembly disposed in a fluid medium flow path between the syringe and the delivery catheter. The flow diverter assembly is configured to divert the portion of the fluid medium from the chamber of the syringe away from the delivery of the medium through the delivery catheter conduit during injecting with the syringe. The flow diverter assembly simultaneously increases fluid medium flow resistance with increasing pressure level of the fluid medium passing into the flow diverter assembly.Type: GrantFiled: February 28, 2018Date of Patent: November 17, 2020Assignee: Osprey Medical, Inc.Inventors: Matthew M. Burns, Tuan M. Doan, Rodney L. Houfburg, David M. Kaye, Todd J. Mortier
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Publication number: 20200345933Abstract: A system for modulating delivery of a fluid medium includes an injector for injecting the fluid medium during an injection cycle, a delivery catheter including a conduit for delivering the fluid medium, a manifold disposed in a fluid medium flow path between the injector and the delivery catheter, and a pulsatile generator. The pulsatile generator is configured to apply a pulsatile force to the fluid medium defined by a plurality of duty cycles during the injection cycle, each of the duty cycles including a first pressure level and a second pressure level that is lower than the first pressure level.Type: ApplicationFiled: May 11, 2020Publication date: November 5, 2020Inventors: Matthew M. Burns, Tuan M, Doan, Rodney L. Houfburg, David M. Kaye, Todd J. Mortier
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Publication number: 20200069867Abstract: Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.Type: ApplicationFiled: November 11, 2019Publication date: March 5, 2020Inventors: Matthew M. Burns, Tuan M. Doan, Rodney L. Houfburg, David M. Kaye, Daniel R. Mans, Todd J. Mortier
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Publication number: 20190307951Abstract: Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.Type: ApplicationFiled: May 21, 2019Publication date: October 10, 2019Inventors: Matthew M. Burns, Tuan M. Doan, Rodney L. Houfburg, David M. Kaye, Daniel R. Mans, Todd J. Mortier
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Patent number: 10335539Abstract: Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.Type: GrantFiled: March 25, 2016Date of Patent: July 2, 2019Assignee: Osprey Medical, Inc.Inventors: Matthew M. Burns, Tuan M. Doan, Rodney L. Houfburg, David M. Kaye, Daniel R. Mans, Todd J. Mortier
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Patent number: 10279104Abstract: Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.Type: GrantFiled: March 17, 2015Date of Patent: May 7, 2019Assignee: Osprey Medical, Inc.Inventors: Matthew M. Burns, Tuan M. Doan, Rodney L. Houfburg, David M. Kaye, Daniel R. Mans, Todd J. Mortier
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Publication number: 20180185576Abstract: A system for modulating delivery of a fluid medium to a selected site within a patient's body includes a syringe for injecting the fluid medium, a delivery catheter including a conduit for delivering the fluid medium from outside of the body to the selected site within the body, and a flow diverter assembly disposed in a fluid medium flow path between the syringe and the delivery catheter. The syringe includes a chamber for receiving the fluid medium therein. The flow diverter assembly is configured to simultaneously divert at least some of the fluid medium within the chamber of the syringe away from the delivery of the medium through the delivery catheter conduit during injecting with the syringe, and wherein the flow diverter assembly creates increasing medium fluid flow resistance with increasing pressure level of the fluid medium within the flow diverter assembly. A method for modulating fluid delivery to a selected site within a patient's body is also disclosed.Type: ApplicationFiled: February 28, 2018Publication date: July 5, 2018Inventors: Matthew M. Burns, Tuan M. Doan, Rodney L. Houfburg, David M. Kaye, Todd J. Mortier
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Patent number: 10010673Abstract: A system for modulating delivery of a fluid medium to a selected site within a patient's body includes a syringe for injecting the fluid medium, a delivery catheter including a conduit for delivering the fluid medium from outside of the body to the selected site within the body, a medium reservoir configured to receive a portion of the fluid medium, and a flow diverter assembly disposed in a fluid medium flow path between the syringe and the delivery catheter. The syringe includes a chamber for receiving the fluid medium therein. The flow diverter assembly is configured to divert the portion of the fluid medium from the chamber of the syringe away from the delivery of the medium through the delivery catheter conduit during injecting with the syringe, and simultaneously increase medium fluid flow resistance with increasing pressure level of the fluid medium within the flow diverter assembly.Type: GrantFiled: September 11, 2015Date of Patent: July 3, 2018Assignee: Osprey Medical, Inc.Inventors: Matthew M. Burns, Tuan M. Doan, Rodney L. Houfburg, David M. Kaye, Todd J. Mortier
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Publication number: 20160310660Abstract: Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.Type: ApplicationFiled: March 25, 2016Publication date: October 27, 2016Inventors: Matthew M. Burns, Tuan M. Doan, Rodney L. Houfburg, David M. Kaye, Daniel R. Mans, Todd J. Mortier
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Patent number: 9320846Abstract: Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.Type: GrantFiled: March 15, 2013Date of Patent: April 26, 2016Assignee: Osprey Medical, Inc.Inventors: Matthew M. Burns, Tuan M. Doan, Rodney L. Houfburg, David M. Kaye, Daniel R. Mans, Todd J. Mortier
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Publication number: 20160106915Abstract: A system for modulating delivery of a fluid medium to a selected site within a patient's body includes a syringe for injecting the fluid medium, a delivery catheter including a conduit for delivering the fluid medium from outside of the body to the selected site within the body, and a flow diverter assembly disposed in a fluid medium flow path between the syringe and the delivery catheter. The syringe includes a chamber for receiving the fluid medium therein. The flow diverter assembly is configured to simultaneously divert at least some of the fluid medium within the chamber of the syringe away from the delivery of the medium through the delivery catheter conduit during injecting with the syringe, and wherein the flow diverter assembly creates increasing medium fluid flow resistance with increasing pressure level of the fluid medium within the flow diverter assembly. A method for modulating fluid delivery to a selected site within a patient's body is also disclosed.Type: ApplicationFiled: September 11, 2015Publication date: April 21, 2016Inventors: Matthew M. Burns, Tuan M. Doan, Rodney L. Houfburg, David M. Kaye, Todd J. Mortier
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Publication number: 20150265761Abstract: Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.Type: ApplicationFiled: March 17, 2015Publication date: September 24, 2015Inventors: Matthew M. Burns, Tuan M. Doan, Rodney L. Houfburg, David M. Kaye, Daniel R. Mans, Todd J. Mortier
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Publication number: 20140066891Abstract: Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.Type: ApplicationFiled: March 15, 2013Publication date: March 6, 2014Inventors: Matthew M. Burns, Tuan M. Doan, Rodney L. Houfburg, David M. Kaye, Daniel R. Mans, Todd J. Mortier
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Patent number: 7956219Abstract: In the present specification we describe a new class of compounds, designed to modulate the ability of blood vessels to synthesize NO from L-arginine. In particular we have identified novel compounds which enhance the entry of L-arginine into cells. These compounds improve endothelial function, and thereby have the potential to retard the progression of vascular disease in conditions such as hypertension, heart failure and diabetes. This new class of drugs may also have other potentially, relevant pharmacological actions, including anti-hypertensive and anti-anginal actions.Type: GrantFiled: May 8, 2003Date of Patent: June 7, 2011Assignee: Baker IDI Heart and DiabetesInventors: Nicholas J. Ede, David M. Kaye, Robert W. Trainor, Andrew N. Hunter
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Patent number: 7591826Abstract: A device, system and method provides mitral valve therapy. The device is implantable in the coronary sinus of the heart to partially encircle the mitral valve annulus. The device is elongated, is resilient, and has a preformed arched configuration. When the device is implanted in the coronary sinus, the device exerts a substantially radially inward force to the mitral valve to restore mitral valve annulus geometry.Type: GrantFiled: December 28, 2000Date of Patent: September 22, 2009Assignee: Cardiac Dimensions, Inc.Inventors: Clifton A. Alferness, David M. Kaye
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Publication number: 20020087173Abstract: A device, system and method for treating a mitral valve is disclosed. The device is implantable in the coronary sinus of the heart to partially encircle the mitral valve annulus. The device is elongated, is resilient, and has a preformed arched configuration. When the device is implanted in the coronary sinus, the device exerts a substantially radially inward force to the mitral valve to restore mitral valve annulus geometry.Type: ApplicationFiled: December 28, 2000Publication date: July 4, 2002Inventors: Clifton A. Alferness, David M. Kaye