Patents by Inventor David M. Segal

David M. Segal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5888773
    Abstract: The invention relates to a method of producing single-chain Fv molecules in eukaryotic cells, and to secretable sFv proteins having at least one non-naturally occurring glycosylation site. The single-chain Fv molecules produced by this method are biologically active and capable of being secreted from eukaryotic cells into the cell culture medium.
    Type: Grant
    Filed: August 17, 1994
    Date of Patent: March 30, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Carolina R. Jost, David M. Segal, James S. Huston
  • Patent number: 5861156
    Abstract: Methods of delivering agents to target cells including methods of immunotherapy, are disclosed in which monospecific binding proteins are administered to a host and bind to target cells followed by administration of multivalent antibodies to direct the agents to the target cells.
    Type: Grant
    Filed: January 8, 1993
    Date of Patent: January 19, 1999
    Assignees: Creative BioMolecules, The United States of America as represented by the Department of Health and Human Services
    Inventors: Andrew J. T. George, David M. Segal, James S. Huston
  • Patent number: 4676980
    Abstract: The present invention discloses a target specific cross-linked heteroantibody and a method of producing the same. The cross-linked heteroantibodies of the present invention can cause normal autologous cells of the immune system to destroy any unwanted cell for which an antibody is available. Treatment or control of tumors, viral infected cells, fungi, bacteria, parasites and the like is now made possible through the use of the heteroantibody complex of the present invention.
    Type: Grant
    Filed: September 23, 1985
    Date of Patent: June 30, 1987
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: David M. Segal, Pilar Perez