Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.

Abstract: In some examples, a system can execute an iterative optimization routine on a set of candidate physical locations for an object. Each iteration can involve a series of operations. The operations can include selecting one of the candidate physical locations; determining a predicted demand value for the candidate physical location based on a first traffic score and a second traffic score associated with the candidate physical location; and determining a predicted overhead value for the candidate physical location. The operations can also include determining a predicted cannibalization factor for the candidate physical location; and generating an overall score for the candidate physical location based on the predicted demand value, the plurality of predicted overhead values, and the predicted cannibalization factor. The system may then identify one or more of the candidate physical locations as optimal locations based on their overall scores and display the optimal locations on a geographical map.

Abstract: System, methods, and other embodiments described herein relate to improving security of protected values in a memory. In one embodiment, a method includes, in response to receiving a write request indicating at least an item and a write value to write into the memory, determining whether a protected items list (PIL) indicates that the item is protected. The method includes replacing the write value of the write request with a protected value from the PIL that corresponds with the item when the item is listed in the PIL as being protected. The method further includes executing the write request to the memory.

Abstract: System, methods, and other embodiments described herein relate to improving security of protected values in a memory. In one embodiment, a method includes, in response to receiving a write request indicating at least an item and a write value to write into the memory, determining whether a protected items list (PIL) indicates that the item is protected. The method includes replacing the write value of the write request with a protected value from the PIL that corresponds with the item when the item is listed in the PIL as being protected. The method further includes executing the write request to the memory.