Abstract: A computerized method and system is provided for automatically selecting from a digitized sound sample a segment of the sample that is optimal for the purpose of measuring clinical metrics for voice and speech assessment. A quality measure based on quality parameters of segments of the sound sample is applied to candidate segments to identify the highest quality segment within the sound sample. The invention can optionally provide feedback to the speaker to help the speaker increase the quality of the sound sample provided. The invention also can optionally perform sound pressure level calibration and noise calibration. The invention may optionally compute clinical metrics on the selected segment and may further include a normative database method or system for storing and analyzing clinical measurements.

Abstract: A microfabricated fluidic unidirectional valve includes a microfabricated elastomer material having a flow through channel. The microfabricated fluidic unidirectional valve also includes an elastomer flap attached to the elastomer material in the flow through channel. The elastomer flap forms a seal in the flow through channel to prevent fluid from flowing in a first direction through the flow through channel and to allow fluid flow in a second direction through the flow through channel.

Abstract: A computerized method and system is provided for automatically selecting from a digitized sound sample a segment of the sample that is optimal for the purpose of measuring clinical metrics for voice and speech assessment. A quality measure based on quality parameters of segments of the sound sample is applied to candidate segments to identify the highest quality segment within the sound sample. The invention can optionally provide feedback to the speaker to help the speaker increase the quality of the sound sample provided. The invention also can optionally perform sound pressure level calibration and noise calibration. The invention may optionally compute clinical metrics on the selected segment and may further include a normative database method or system for storing and analyzing clinical measurements.

Abstract: A computerized system and method is provided for managing normative data for metrics and comparing those normative data with metric values for a subject. The normative database provides a means for storing and utilizing normative data from multiple studies and the system automatically determines, or optionally allows a user to determine, which studies will be used in the comparison. The system also optionally allows a user to modify normative data in the normative database or add normative data to the normative database. The system generates images showing the relationship of the metric values to the normative data, optionally utilizing one or more thresholds extracted from the database or provided by the user.

Abstract: Microfabricated fluidic devices of the present invention include switches that can be opened and closed to allow or block the flow of fluid through a channel in response to the pressure level in a gate of the switch. The microfabricated fluidic switches may be coupled together to perform logic functions and Boolean algebra, such as inverters, AND gates, NAND, gates, NOR gates, and OR gates. The logic gates may be coupled together to form flip-flops that latch signals. The present invention also includes microfabricated fluidic pressure multipliers that increase the pressure in a second chamber relative to a first chamber. Microfabricated fluidic devices of the present invention also include high or low pressure sources. A pressure source of the present includes a pump coupled to a reservoir through unidirectional valves. Microfabricated fluidic devices of the present invention may also include devices that perform analog functions such as switching regulator.

Abstract: The present invention provides microfabricated fluidic systems and methods. Microfabricated fluidic devices of the present invention include switches that can be opened and closed to allow or block the flow of fluid through a channel in response to the pressure level in a gate of the switch. The microfabricated fluidic switches may be coupled together to perform logic functions and Boolean algebra, such as inverters, AND gates, NAND, gates, NOR gates, and OR gates. The logic gates may be coupled together to form flip-flops that latch signals. The present invention also includes microfabricated fluidic pressure multipliers that increase the pressure in a second chamber relative to a first chamber. Microfabricated fluidic devices of the present invention also include pressure sources. A pressure source of the present includes a pump coupled to a reservoir through unidirectional valves. The pressure source may be high pressure source or a low pressure source.

Abstract: The present invention provides microfabricated fluidic systems and methods. Microfabricated fluidic devices of the present invention include switches that can be opened and closed to allow or block the flow of fluid through a channel in response to the pressure level in a gate of the switch. The microfabricated fluidic switches may be coupled together to perform logic functions and Boolean algebra, such as inverters, AND gates, NAND, gates, NOR gates, and OR gates. The logic gates may be coupled together to form flip-flops that latch signals. The present invention also includes microfabricated fluidic pressure multipliers that increase the pressure in a second chamber relative to a first chamber. Microfabricated fluidic devices of the present invention also include pressure sources. A pressure source of the present includes a pump coupled to a reservoir through unidirectional valves. The pressure source may be high pressure source or a low pressure source.

Abstract: The present invention provides microfabricated fluidic systems and methods. Microfabricated fluidic devices of the present invention include switches that can be opened and closed to allow or block the flow of fluid through a channel in response to the pressure level in a gate of the switch. The microfabricated fluidic switches may be coupled together to perform logic functions and Boolean algebra, such as inverters, AND gates, NAND, gates, NOR gates, and OR gates. The logic gates may be coupled together to form flip-flops that latch signals. The present invention also includes microfabricated fluidic pressure multipliers that increase the pressure in a second chamber relative to a first chamber. Microfabricated fluidic devices of the present invention also include pressure sources. A pressure source of the present includes a pump coupled to a reservoir through unidirectional valves. The pressure source may be high pressure source or a low pressure source.