Abstract: The invention provides polyol (allyl carbonate) polymer solid supports. The supports can be modified for attachment of a chemical moiety or ligand. A solid support comprising one or more ligands immobilized to a polyol (allyl carbonate) polymer solid support. The solid support can be in the form of a bead, fiber, flat surface, microfluidic device, molded device, machined device, container, multi-well container such as a multi-well plate, and mass spectrometry sample holder. The solid supports can be used for a variety of applications, including chemical storage, chemical synthesis, combinatorial library synthesis, analytical devices, diagnostic devices, and tissue culture applications. The invention also provides methods of using the polyol (allyl carbonate) polymer solid supports.

Abstract: The invention provides polyol (allyl carbonate) polymer for electrokinetic devices. The devices can be modified for attachment of a chemical moiety or ligand. The electrokinetic devices can be used for a variety of applications, including chemical analysis, biochemical analysis, cell sorting, purification, analytical devices, diagnostic devices, and tissue culture applications. The invention also provides methods of using the polyol (allyl carbonate) polymer electrokinetic devices. The invention also provides for a sensor that allows for the detection of various chemicals, biochemicals, ions, metals, solvents, and bio-polymers.

Abstract: The invention provides a method of generating an array of molecules. The method includes the steps of attaching one or more chemical moieties to a plurality of waveguides; distributing the plurality of waveguides in a predetermined arrangement in a grid, the grid thereby spacing the waveguides at a predetermined distance; embedding the plurality of waveguides in an inert support; and slicing the embedded plurality of waveguides transversely, thereby generating an array of molecules. A non-end portion of the embedded waveguides can be removed from at least one face of the slice. The waveguides can also be coated with cladding to effect spacing at a predetermined distance. The invention also provides compositions comprising a plurality of waveguides embedded in an inert support, the waveguides having attached thereto one or more chemical moieties, having a non-end portion exposed, and being spaced at a distance to minimize crosstalk between waveguides.

Abstract: The invention provides polyol (allyl carbonate) polymer solid supports. The supports can be modified for attachment of a chemical moiety or ligand. A solid support comprising one or more ligands immobilized to a polyol (allyl carbonate) polymer solid support. The solid support can be in the form of a bead, fiber, flat surface, microfluidic device, molded device, machined device, container, multi-well container such as a multi-well plate, and mass spectrometry sample holder. The solid supports can be used for a variety of applications, including chemical storage, chemical synthesis, combinatorial library synthesis, analytical devices, diagnostic devices, and tissue culture applications. The invention also provides methods of using the polyol (allyl carbonate) polymer solid supports.

Abstract: The invention provides an apparatus for fluorescence detection, comprising a light source for illuminating a portion of a solid support; a means for splitting light emanating from the light source into two or more split beams of light; a means for polarizing the beams of light; a means for collimating the polarized light; a ¼-wave plate disposed between the collimating means and the solid support for converting the collimated light into polarized light; a means for focusing the polarized light onto the solid support; a means for detecting a fluorescence emission; a means for filtering the fluorescence emission; and a photodetector array.

Abstract: The invention provides an apparatus for chemical synthesis comprising a light source, for example, a laser light source; a means for dispensing a chemical reagent onto the solid support; a means for splitting light emanating from the light source into two or more split beams of light; a means for polarizing the beams of light; a means for collimating the polarized light; a ¼-wave plate disposed between the collimating means and the solid support; a means for focusing the polarized light onto the solid support; and a photodetector array.

Abstract: The invention provides a composition comprising a diverse population of reagent ligands attached to a solid support and a diverse population of reagent antibodies specifically bound to the reagent ligands. The ligands can be peptides, oligosaccharides, oligonucleotides, or organic molecules. The invention additionally provides methods of determining an epitope in a sample contacting a composition comprising a diverse population of ligands attached to a solid support and a diverse population of antibodies specifically bound to each of the ligands with a sample; and detecting the antibodies bound to the diverse population of ligands. The invention further provides methods of diagnosing a disease, identifying a potential therapeutic agent, and mapping accessible epitopes of a polypeptide using invention compositions.