Patents by Inventor David S. Scher

David S. Scher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20040028733
    Abstract: This invention relates to sustained release compositions, and methods of forming and using said compositions, in particular for the sustained release of Follicle Stimulating Hormone (FSH). The sustained release compositions comprise a polymeric matrix of a biodegradable biocompatible polymer and stabilized FSH. The method of the invention for forming a sustained release composition includes, dissolving a biodegradable biocompatible polymer in a polymer solvent to form a polymer solution; adding biologically active stabilized FSH; removing the solvent; and solidifying the polymer to form a polymer matrix containing stabilized FSH dispersed therein. Also described is a method for providing a therapeutically effective amount of stabilized FSH in a patient in need of for a sustained period comprising administering to the patient a dose of the sustained release compositions of the invention.
    Type: Application
    Filed: February 7, 2003
    Publication date: February 12, 2004
    Applicant: Alkermes Controlled Therapeutics, Inc.
    Inventors: Mark A. Tracy, Henry R. Costantino, Maria Figueiredo, Kevin L. Ward, David S. Scher
  • Publication number: 20030138491
    Abstract: This invention relates to sustained release compositions, and methods of forming and using said compositions, for the sustained release of biologically active acid-stable or free sulfhydryl-containing proteins, in particular &bgr;-IFN. The sustained release composition of this invention comprises a biocompatible polymer having dispersed therein a stabilized biologically active acid-stable or free sulfhydryl-containing protein formulation and a nonionic polymer surfactant.
    Type: Application
    Filed: August 13, 2002
    Publication date: July 24, 2003
    Applicant: Alkermes Controlled Therapeutics, Inc.
    Inventors: Mark A. Tracy, Kevin L. Ward, David S. Scher, J. Keith Johnson
  • Patent number: 6565888
    Abstract: The present invention relates to a sustained release composition for the targeted delivery of biologically active agents to specific tissues and cells. The composition comprises microparticles containing a biocompatible polymer, a water-soluble polymer and a biologically active agent. In one embodiment, the biologically active agent is an antigen or an immunomodulator. In another embodiment, the biologically is a labile agent. The microparticles have a number median diameter of greater than 20 microns upon administration. The water-soluble polymer is present in the sustained released composition in at least about 20% of the dry weight of the microparticle. The sustained release composition provides for the dissolution of the water-soluble polymer of the composition upon hydration, at a much greater rate than the degradation of the biocompatible polymer.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: May 20, 2003
    Assignee: Alkermes Controlled Therapeutics, Inc.
    Inventors: Mark A. Tracy, David S. Scher
  • Patent number: 6465425
    Abstract: This invention relates to sustained release compositions, and methods of forming and using said compositions, for the sustained release of biologically active acid-stable or free sulfhydryl-containing proteins, in particular &bgr;-IFN. The sustained release composition of this invention comprises a biocompatible polymer having dispersed therein a stabilized biologically active acid-stable or free sulfhydryl-containing protein formulation and a nonionic polymer surfactant.
    Type: Grant
    Filed: February 10, 2000
    Date of Patent: October 15, 2002
    Assignee: Alkermes Controlled Therapeutics, Inc.
    Inventors: Mark A. Tracy, Kevin L. Ward, David S. Scher, J. Keith Johnson