Patents by Inventor David Thompson Berg

David Thompson Berg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS OF USE FOR SOLUBLE THROMBOMODULIN VARIANTS
    Publication number: 20110207670
    Abstract: The present invention provides a method for preventing and/or treating a patient with acute kidney injury caused by a variety of conditions. The method comprises administering to the patient soluble thrombomodulin variants that do not bind thrombin. In conjunction with standard of care, soluble thrombomodulin variants that do not bind thrombin will prevent or reduce acute kidney injury and subsequent morbidity and mortality.
    Type: Application
    Filed: October 21, 2009
    Publication date: August 25, 2011
    Applicant: ELI LILLY AND COMPANY
    Inventors: David Thompson Berg, Brian William Grinnell, Akanksha Gupta
  • Protein C derivatives
    Patent number: 6998122
    Abstract: Novel protein C derivatives are described. These polypeptides retain the biological activity of the wild-type human protein C with substantially longer half-lives in human blood. These polypeptides will require either less frequent administration and/or smaller dosage than wild-type human protein C in the treatment of vascular occlusive disorders, hypercoagulable states, thrombotic disorders and disease states predisposing to thrombosis.
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: February 14, 2006
    Assignee: Eli Lilly and Company
    Inventors: Bruce Edward Gerlitz, Bryan Edward Jones, David Thompson Berg
  • Effect of compounds that suppress induction of plasminogen activator inhibitor 1 (PAI-1)
    Patent number: 5980938
    Abstract: The present invention provides methods of inhibiting PAI-1 using benzopyrans.
    Type: Grant
    Filed: June 25, 1997
    Date of Patent: November 9, 1999
    Assignee: Eli Lilly and Company
    Inventors: David Thompson Berg, George Joseph Cullinan, Brian William Grinnell, Mark Alan Richardson
  • Benzothiophene compounds, and uses and formulations thereof
    Patent number: 5962698
    Abstract: Novel benzothiophenes, and intermediates thereof, and the uses and formulations thereof, are provided by the present invention.
    Type: Grant
    Filed: June 3, 1998
    Date of Patent: October 5, 1999
    Assignee: Eli Lilly and Company
    Inventors: David Thompson Berg, George Joseph Cullinan, Brian William Grinnell, Mark Alan Richardson
  • Benzothiopene compounds, and uses and formulations thereof
    Patent number: 5948795
    Abstract: Novel benzothiophenes, ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are independently --OH, --OCO(C.sub.1 -C.sub.6 alkyl), --O(CO)O(C.sub.1 -C.sub.6 alkyl), --OCO--Ar, where Ar is phenyl or substituted phenyl, or --O(CO)O--phenyl; and R.sub.4 is N-pyrrolidinyl, N-piperidinyl, or N-hexamethyleneimino, and intermediates thereof, and the uses and formulations thereof, are provided by the present invention.
    Type: Grant
    Filed: June 25, 1997
    Date of Patent: September 7, 1999
    Assignee: Eli Lilly and Company
    Inventors: David Thompson Berg, George Joseph Cullinan, Brian William Grinnell, Mark Alan Richardson
  • Method for inhibiting plasminogen activator inhibitor 1
    Patent number: 5792798
    Abstract: Methods of inhibiting plasminogen activator inhibitor 1 comprising administering to a human in need thereof an effective amount of a compound having the formula I: ##STR1## wherein R.sup.1 and R.sup.2 are, independently, --H, --C.sub.1 -C.sub.4 alkyl, or taken together with the nitrogen to which they are attached form a pyrrolidine, piperidine, or hexamethyleneimino ring;or a pharmaceutically acceptable salt or solvate thereof.
    Type: Grant
    Filed: July 15, 1997
    Date of Patent: August 11, 1998
    Assignee: Eli Lilly and Company
    Inventors: David Thompson Berg, George Joseph Cullinan, Brian William Grinnell, Mark Alan Richardson
  • Benzothiophene compounds, and uses formulations thereof
    Patent number: 5780648
    Abstract: Benzothiophenes, and uses and formulations thereof, are provided by the present invention.
    Type: Grant
    Filed: June 25, 1997
    Date of Patent: July 14, 1998
    Assignee: Eli Lilly and Company
    Inventors: David Thompson Berg, George Joseph Cullinan, Brian William Grinnell, Mark Alan Richardson
  • Methods of inhibiting plasminogen activator inhibitor 1
    Patent number: 5731328
    Abstract: A method of inhibiting plasminogen activator inhibitor 1 comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, --CH.sub.3, ##STR2## wherein Ar is optionally substituted phenyl; R.sup.2 is selected from the group consisting of pyrrolidine, hexamethyleneimino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.
    Type: Grant
    Filed: September 4, 1996
    Date of Patent: March 24, 1998
    Assignee: Eli Lilly and Company
    Inventors: David Thompson Berg, Brian William Grinnell, Mark Alan Richardson