Abstract: The specification describes modified step index and GRaded INdex (GRIN) fibers with low core relative delta (near 0.8%) which have desirable properties for transmission. These lower delta fibers have lower attenuation losses due to reduced Rayleigh scattering, which is desirable to improve performance in multiple mode multiplexing. The fiber designs include optimized raised triangle profiles, and depressed cladding profiles, to support two and four LP modes.

Abstract: Described are optical fibers having a relatively large effective area, large negative dispersion coefficient, and relatively low attenuation. These optical fibers are advantageously paired with positive dispersion coefficient optical fibers for blockless undersea cables.

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

Abstract: An inverse dispersion fiber having a large effective area and a transmission system that incorporates the fiber for providing dispersion and dispersion slope compensation in a transmission fiber. The large-effective-area inverse dispersion optical fiber (IDF) has a negative dispersion and a negative dispersion slope. The effective area, Aeff, of the IDF preferably is greater than approximately 31 micrometers squared (?m2) at a transmission wavelength of approximately 1550 nm. The large-effective-area IDF is suitable for use with super-large-effective-area (SLA) transmission fiber for compensating dispersion in the SLA transmission fiber while reducing nonlinear effects between wavelength channels and cabling loss, which is especially advantageous in transoceanic and long-haul terrestrial systems. These nonlinear effects are inversely related to the effective area of the fiber (i.e., nonlinearities˜1/Aeff).

Abstract: A super-large-effective-area (SLA) optical fiber that is suitable for communicating over a wide wavelength range and that, because of its large effective area, suppresses nonlinear effects that typically result from interaction between signal channels. The effective area, Aeff, of the SLA fiber of the present invention preferably is equal to or greater than approximately 80 ?m2 at a wavelength window around 1310 nm. The cutoff wavelength of the SLA fiber of the present invention preferably is less than 1310 nm. Thus, the SLA fiber of the present invention has a very large effective area and a very low cutoff wavelength. In accordance with the present invention, a variety of SLA fibers are provided that all have very large effective areas and desirable transmission properties. The large effective areas of the SLA fibers of the present invention enable nonlinear effects to be suppressed, as well as Stimulated Brillouin Scattering in analog transmission.

Abstract: An inverse dispersion fiber having a large effective area and a transmission system that incorporates the fiber for providing dispersion and dispersion slope compensation in a transmission fiber. The large-effective-area inverse dispersion optical fiber (IDF) has a negative dispersion and a negative dispersion slope. The effective area, Aeff, of the IDF preferably is greater than approximately 31 micrometers squared (&mgr;m2) at a transmission wavelength of approximately 1550 nm. The large-effective-area IDF is suitable for use with super-large-effective-area (SLA) transmission fiber for compensating dispersion in the SLA transmission fiber while reducing nonlinear effects between wavelength channels and cabling loss, which is especially advantageous in transoceanic and long-haul terrestrial systems. These nonlinear effects are inversely related to the effective area of the fiber (i.e., nonlinearities ˜1/Aeff).

Abstract: A super-large-effective-area (SLA) optical fiber that is suitable for communicating over a wide wavelength range and that, because of its large effective area, suppresses nonlinear effects that typically result from interaction between signal channels. The effective area, Aeff, of the SLA fiber of the present invention preferably is equal to or greater than approximately 80 &mgr;m2 at a wavelength window around 1310 nm. The cutoff wavelength of the SLA fiber of the present invention preferably is less than 1310 nm. Thus, the SLA fiber of the present invention has a very large effective area and a very low cutoff wavelength. In accordance with the present invention, a variety of SLA fibers are provided that all have very large effective areas and desirable transmission properties. The large effective areas of the SLA fibers of the present invention enable nonlinear effects to be suppressed, as well as Stimulated Brillouin Scattering in analog transmission.

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

Abstract: Embodiments of the invention include an optical communications system including one or more optical transmission devices, one or more optical receiving devices, and at least one positive dispersion optical fiber coupled therebetween. The fiber includes a doped core region with an index of refraction n1, a cladding region with an index of refraction n2, and first and second annular rings or regions therebetween with indices of refraction n3 and n4, respectively. The various regions are manufactured in such a way that the refractive index value ranges are: 0.14<(n1−n2)/n2<0.31, −0.19<(n3−n2)/n2<−0.02, and −0.20<(n4−n2)/n2<−0.08. The fibers exhibit a chromatic dispersion greater than 20±2.0 ps/(nm-km) and a dispersion slope less than 0.062 ps/(nm2-km) at a wavelength of 1550 nm. Also, the fibers have a relatively large effective core area, Aeff, e.g., greater than 100.0 &mgr;m2, and a relative dispersion slope (RDS) less than 0.0032 nm−1.

Abstract: Embodiments of the invention include an optical communications system including one or more optical transmission devices, one or more optical receiving devices, and at least one positive dispersion optical fiber coupled therebetween. The fiber includes a doped core region with an index of refraction n1, a cladding region with an index of refraction n2, and first and second annular rings or regions therebetween with indices of refraction n3 and n4, respectively. The various regions are manufactured in such a way that the refractive index value ranges are: 0.14<(n1−n2)/n2<0.31, −0.19<(n3−n2)/n2<−0.02, and −0.20<(n4−n2)/n2<−0.08. The fibers exhibit a chromatic dispersion greater than 20±2.0 ps/(nm-km) and a dispersion slope less than 0.062 ps/(nm2-km) at a wavelength of 1550 nm. Also, the fibers have a relatively large effective core area, Aeff, e.g., greater than 100.0 &mgr;m2, and a relative dispersion slope (RDS) less than 0.0032 nm−1.

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

Abstract: An optical fiber is disclosed that is suitable for use in wave-division-multiplex (WDM) systems served by Erbium-doped fiber amplifiers. The fiber has a chromatic dispersion whose absolute magnitude is at least 0.8 ps/(nm-km) over the wavelength region 1530-1565 nm, and has a dispersion slope that is less than 0.05 ps/(nm.sup.2 -km). This optical fiber exhibits a loss that is less than about 0.20 dB/km and is relatively insensitive to bending; moreover, its effective area exceeds 50 .mu.m.sup.2. The optical fiber includes a core of transparent material having a maximum refractive index n.sub.1, and a layer of transparent cladding material on the outer surface of said core having a refractive index n.sub.2. The core includes an annular region of transparent material whose minimum refractive index, n.sub.3, is depressed with respect to n.sub.2. These indexes are constrained by the following equations: 0.50<(n.sub.1 -n.sub.2)/n.sub.2 <0.70; and -0.30<(n.sub.3 -n.sub.2)/n.sub.2 <-0.05.