Abstract: The present invention is directed to an edible film that contains two or more segmented portions and comprises an active ingredient that is distributed on a segmented portion or portions which comprise less than 50% of the cross sectional surface area of a major face of said film. The present invention also relates to methods of treatment for the treatment of various conditions and for taste-masking of pharmaceutical ingredients.

Abstract: The present invention features a tablet including one or more pharmaceutically active agent(s), one or more thickeners, and one or more binder(s), wherein the tablet includes at least 200 mg of the pharmaceutically active agent(s) and the tablet has been fused with the binder(s) such that the tablet (i) has a water permeation time of less than 60 seconds and (ii) has an in vitro disintegration time of greater than 60 seconds.

Abstract: The present invention features a method of manufacturing a tablet containing a pharmaceutically active agent by the steps of: (a) adding a powder containing a pharmaceutically-acceptable carrier to a die cavity; (b) injecting a liquid drug composition containing the pharmaceutically active agent into the die cavity such that the liquid drug composition contacts the powder; (c) compressing the combination of the powder and the liquid drug composition within the die cavity to form the tablet; and (d) removing the tablet from the die cavity.

Abstract: In one aspect, the present invention features a method of administering an active ingredient, said method comprising chewing an oral dosage form comprising a texture masked particle, said texture masked particle comprising a) a core containing an active ingredient; b) a first coating layer comprised of a taste masking agent that substantially covers the core, wherein said taste masking agent is comprised of an insoluble film forming polymer and a non-enteric, water soluble polymer; and c) a second coating layer on the surface of the first coating layer.

Abstract: A thermal treatment device having at least one fast-acting heat pack and at least one long lasting heat pack is disclosed.

Abstract: A thermal treatment device having variable heat distribution along the device is disclosed.

Abstract: Oral dosage forms, and particles used therein, containing salivation inducing agents are disclosed. The salivation agents may be in the core of the dosage form and/or in coatings applied thereto, or alternatively may be within particles and/or the matrix of such dosage forms, in coatings applied to such particles, or on the surface of such coated particles. The particles may be produced into a tablet form, such as a chewable tablet form, that provides for the immediate release of the active ingredient. Other oral dosage forms include thin film strips, gummi, foam tabs, and lozenges.

Abstract: The present invention features a tablet including one or more pharmaceutically active agent(s), one or more thickeners, and one or more binder(s), wherein the tablet includes at least 200 mg of the pharmaceutically active agent(s) and the tablet has been fused with the binder(s) such that the tablet (i) has a water permeation time of less than 60 seconds and (ii) has an in vitro disintegration time of greater than 60 seconds.

Abstract: The present invention is directed to an edible film that contains two or more segmented portions and comprises an active ingredient that is distributed on a segmented portion or portions which comprise less than 50% of the cross sectional surface area of a major face of said film. The present invention also relates to methods of treatment for the treatment of various conditions and for taste-masking of pharmaceutical ingredients.

Abstract: Oral dosage forms, and particles used therein, containing salivation inducing agents are disclosed. The salivation agents may be in the core of the dosage form and/or in coatings applied thereto, or alternatively may be within particles and/or the matrix of such dosage forms, in coatings applied to such particles, or on the surface of such coated particles. The particles may be produced into a tablet form, such as a chewable tablet form, that provides for the immediate release of the active ingredient. Other oral dosage forms include thin film strips, gummi, foam tabs, and lozenges.

Abstract: The present invention features a method of manufacturing a tablet containing a pharmaceutically active agent by the steps of: (a) adding a powder containing a pharmaceutically-acceptable carrier to a die cavity; (b) injecting a liquid drug composition containing the pharmaceutically active agent into the die cavity such that the liquid drug composition contacts the powder; (c) compressing the combination of the powder and the liquid drug composition within the die cavity to form the tablet; and (d) removing the tablet from the die cavity.

Abstract: The present invention is directed to a topical composition comprising a counterirritant active ingredient and a sensate that provides a cooling sensation to the skin that is topically perceptible to an adult human subject for greater than about 90 minutes, e.g. greater than about 120 minutes, say greater than about 150 minutes, when applied in an effective amount over an area on the back of a hand, elbow, lower back or shoulder region. In one embodiment, the sensate can be encapsulated. The sensate can alternatively be bound to an ion exchange resin or adsorbed onto an adsorbant.

Abstract: A method is provided for providing protection for connectionless signals in a telecommunications network comprising a plurality of nodes. A first protection path is generated from each of the nodes to a destination node. A second protection path is generated from each of the nodes to the destination node. The second protection path is distinct from the first protection path. Protection traffic is routed along one of the protection paths to the destination node.

Abstract: Taste masked particles and chewable tablets made therefrom are disclosed. The taste masked particles comprise a core containing an active ingredient and a polymeric coating covering said core, said coating comprising a mixture of a) an enteric polymer; and b) an insoluble film forming polymer, the surface of said particle being free of active ingredient. The chewable tablets provide immediate release of the active ingredient.

Abstract: A method of communicating connectionless and connection oriented signals using at least one common network element includes receiving connectionless and connection oriented signals from a plurality of source peripheral network elements and determining a signaling type associated with each signal, the signaling type comprising connectionless signaling or connection oriented signaling. The method further includes appending a transport label to each signal, each transport label comprising an indication of the signal's signaling type, and communicating the signals and appended transport labels toward destination peripheral network elements according to signaling procedures associated with each signal's signaling type.

Abstract: A transport network includes a flexible topology for internally defining transport elements. The transport elements each include a port group having a plurality of geographically distributed ports from the transport network. Point-to-multipoint connectivity is defined between the ports in a port group. An identifier represents the port group as a single element to internal and/or external elements for protocol exchanges.

Abstract: A system is provided for providing a protection path for connection-oriented signals in a telecommunications network comprising a plurality of nodes. The system includes a source node, a destination node and a penultimate node. The source node is operable to transmit traffic. The destination node is operable to receive traffic from the source node. The penultimate node is operable to receive traffic from the source node, to transmit traffic directly to the destination node, to designate one of the nodes as a reflector and to generate a first segment of a protection path from the penultimate node through the reflector to the destination node.

Abstract: In particular embodiments, the present invention provides an apparatus for controlling a signaling link. The apparatus includes a plurality of receivers and a plurality of drivers. Each receiver receives signaling messages from one of a plurality of first signaling links, and each driver sends signaling messages over one of a plurality of second signaling links. The apparatus also includes an interface that receives signaling messages and control data from a control module and sends signaling messages and control data to the control module. The apparatus further includes a processor coupled to the receivers, the drivers, and the interface. The processor receives signaling messages from the receivers and multiplexes portions of the signaling messages together for communication through the interface. The processor also receives portions of signaling messages from the interface and demultiplexes the portions for communication to the drivers.

Abstract: Texture masked particles and chewable tablets made therefrom are disclosed. The texture masked particles are comprised of a core containing an active ingredient, an optional first coating layer comprised of a taste masking agent that substantially covers the core; and a second coating layer, which optionally may substantially cover the first coating layer or the core, comprised of a film forming polymer and a anti-grit agent. The particles may be produced into a tablet form, such as a chewable tablet form, that provides for the immediate release of the active ingredient.

Abstract: The present invention provides a composition comprising a) a laxative selected from the group consisting of bisacodyl and enteric coated vanilloid compounds; and b) simethicone in an amount effective to enhance the efficacy of the laxative. The simethicone enhances the transit of the laxatives through the small bowel.