Patents by Inventor David Walsh

David Walsh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4898874
    Abstract: 3-Aryl-2,1-benzisoxazole compounds having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen or methyl;R.sup.3 and R.sup.4 are hydroxyl, loweralkoxy, amino or --OM wherein M is a pharmaceutically acceptable cation;X is hydrogen, halogen, loweralkyl or nitro;Y is selected from hydrogen, halogen, loweralkyl, loweralkoxy, nitro or trifluoromethyl;n and p are zero or one with the proviso that either n or p must be oneare disclosed, having anti-inflammatory activity and novel intermediates in the preparation thereof.
    Type: Grant
    Filed: September 15, 1986
    Date of Patent: February 6, 1990
    Assignee: A. H. Robins Company, Inc.
    Inventors: David A. Walsh, Ibrahim M. Uwaydah
  • Patent number: 4886794
    Abstract: 4-[(.alpha.,.alpha.-Diaryl)-hydroxymethyl]-1-piperidinylalkylcyclic carbamate derivatives having the formula: ##STR1## wherein; R is hydrogen, loweralkyl, cycloalkyl, phenyl and substituted phenyl;Ar and Ar.sup.1 are phenyl, substituted phenyl or pyridinyl;alk is a straight or branched hydrocarbon chain;R.sup.1 is loweralkyl substituted for hydrogen on a ring carbon.The compounds are useful antihistamines and in controlling allergic response.
    Type: Grant
    Filed: June 3, 1988
    Date of Patent: December 12, 1989
    Assignee: A. H. Robins Company, Incorporated
    Inventor: David A. Walsh
  • Patent number: 4882330
    Abstract: 1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols of the formula: ##STR1## wherein Ar is selected fro ##STR2## or 2, 3 or 4-pyridyl); X and X' are selected from the group of hydrogen, loweralkyl, loweralkoxy, halogen, trifluoromethyl, nitro, acetylamino, phenyl or ##STR3## acetyl, cyano, aminocarbonyl, carboxy, or loweralkyl carboxylic acid ester; Y, Y', Y" are selected from the same group as X and X' except phenyl and substituted phenyl are excluded; Z and Z' are selected from hydrogen, loweralkyl or loweralkoxy and the pharmaceutically acceptable salt thereof are employed in a method of inhibiting or combatting allergic response associated with anaphylactic sensitivity in animals and humans.
    Type: Grant
    Filed: April 6, 1989
    Date of Patent: November 21, 1989
    Assignee: A. H. Robins Company, Incorporated
    Inventors: David A. Walsh, John M. Yanni
  • Patent number: 4855448
    Abstract: 2-Amino-3-aroyl-.gamma.-oxobenzenebutanoic acids and derivatives having the formula: ##STR1## wherein X is hydrogen, halogen, or loweralkyl; Y is hydrogen, halogen, loweralkyl, loweralkoxy, nitro, or trifluoromethyl; n is 1 or 2; and R is hydrogen, loweralkyl, or a pharmaceutically acceptable cation, are disclosed having anti-inflammatory activity.
    Type: Grant
    Filed: August 8, 1988
    Date of Patent: August 8, 1989
    Assignee: A. H. Robins Company, Incorporated
    Inventor: David A. Walsh
  • Patent number: 4855447
    Abstract: 2-Amino-3-aroyl-.gamma.-oxobenzenebutanoic acids and derivatives having the formula: ##STR1## wherein X is hydrogen, halogen, or loweralkyl; Y is hydrogen, halogen, loweralkyl, loweralkoxyl, nitro, or trifluoromethyl; n is 1 or 2; and R is hydrogen lower-alkyl, or a pharmaceutically acceptable cation, are disclosed having anti-inflammatory activity.
    Type: Grant
    Filed: August 8, 1988
    Date of Patent: August 8, 1989
    Assignee: A. H. Robins Company, Incorporated
    Inventor: David A. Walsh
  • Patent number: 4810713
    Abstract: A method of treating allergy with substituted heterocyclic amines is disclosed wherein the active agents are expressed generally by the formula which includes certain known and certain novel compounds: ##STR1## wherein p is zero, one or two; m is one to six inclusive; A is selected from hydrogen, hydroxy or cyano; d is zero or one; Q is --CH--, --CH.sub.2 -- or ##STR2## n is zero or one and when Q is --CH-- and n is one, a double bond is formed with one of the adjacent carbons but not both at the same time, and when n and d are zero at the same time, a double bond is formed between the .alpha.
    Type: Grant
    Filed: December 20, 1985
    Date of Patent: March 7, 1989
    Assignee: A. H. Robins Company, Incorporated
    Inventors: John M. Yanni, David A. Walsh
  • Patent number: 4782089
    Abstract: 2-Amino-3-aroyl-.gamma.-oxobenzenebutanoic acids and derivatives having the formula: ##STR1## wherein X is hydrogen, halogen, or loweralkyl; Y is hydrogen, halogen, loweralkyl, loweralkoxy, nitro, or trifluoromethyl; n is 1 or 2; and R is hydrogen, loweralkyl, or a pharmaceutically acceptable cation, are disclosed having anti-inflammatory activity.
    Type: Grant
    Filed: August 26, 1986
    Date of Patent: November 1, 1988
    Assignee: A. H. Robins Company, Incorporated
    Inventor: David A. Walsh
  • Patent number: 4764165
    Abstract: An ophthalmic aspirator-irrigator system for use during cataract surgery is disclosed. The system frees both hands of the surgeon for the surgical tasks and leaves the automatic operation of the system to a single control input operated by a foot pedal. The pedal controls both the aspiration and ejection functions as well as their respective speeds. The ophthalmic aspirator-irrigator system essentially comprises a hand-held device, a control box operable by the foot pedal and a power cord connecting the device with the box. A source of fluid is connected via a tube to the device to effect the irrigation function. The control box includes a power source and a circuit coupled to the source and via the cord to the device. Preferably, the circuit includes a bridge output network controlled by a linear motion slide type potentiometer controlled by the foot pedal.
    Type: Grant
    Filed: June 25, 1987
    Date of Patent: August 16, 1988
    Assignee: Mentor O & O, Inc.
    Inventors: Harry G. Reimels, David A. Walsh, Michael J. Arsenault
  • Patent number: 4705500
    Abstract: An ophthalmic aspirator-irrigator system for use during cataract surgery is disclosed. The system frees both hands of the surgeon for the surgical tasks and leaves the automatic operation of the system to a single control input operated by a foot pedal. The pedal controls both the aspiration and ejection functions as well as their respective speeds. The opthalmic aspirator-irrigator system essentially comprises a hand-held device, a control box operable by the foot pedal and a power cord connecting the device with the box. A source of fluid is connected via a tube to the device to effect the irrigation function. The control box includes a power source and a circuit coupled to the source and via the cord to the device. Preferably, the circuit includes a bridge output network controlled by a linear motion slide type potentiometer controlled by the foot pedal.
    Type: Grant
    Filed: July 17, 1986
    Date of Patent: November 10, 1987
    Assignee: Mentor O & O, Inc.
    Inventors: Harry G. Reimels, David A. Walsh, Michael J. Arsenault
  • Patent number: 4670566
    Abstract: This invention relates to novel compounds having the formula: ##STR1## wherein; R.sup.1 is fluoro, chloro, bromo, lower-alkyl or nitro,R.sup.2 is lower alkyl, lower alkoxy, fluoro, chloro, bromo, nitro or trifluoromethyl, andm and n are 0-2 with the proviso that when R.sup.1 or R.sup.2 are tertiary butyl or a sterically hindering lower alkyl radical, m and/or n are 1. These compounds are intermediates in the preparation of 2-aminobiphenylacetic acids, esters and metal salts thereof.
    Type: Grant
    Filed: January 19, 1984
    Date of Patent: June 2, 1987
    Assignee: A. H. Robins Company, Incorporated
    Inventor: David A. Walsh
  • Patent number: 4585785
    Abstract: Cis and trans-3-aryloxy-4-hydroxypyrrolidines and derivatives thereof having the formula: ##STR1## are disclosed wherein R.sub.1 is hydrogen, loweralkyl, benzyloxycarbonyl and N-loweralkylcarbamoyl; R.sub.2 is hydrogen, lower alkyl, cycloalkyl, phenylalkyl, benzyloxycarbonyl, carbamoyl, N-loweralkylcarbamoyl, N-diloweralkylcarbamoyl and parafluorobenzoyl-lower-alkyl; Ar is phenyl, substituted phenyl, 1-naphthyl, 2-naphthyl, 1-indenyl and 2-indenyl and pharmaceutically acceptable acid addition and quaternary salts thereof. The compounds have antidepressant, antihypertensive and antiarrythmic activity in animals.
    Type: Grant
    Filed: March 10, 1980
    Date of Patent: April 29, 1986
    Assignee: A. H. Robins Company, Inc.
    Inventors: David A. Walsh, William J. Welstead, Jr.
  • Patent number: 4503073
    Abstract: Novel 2-amino-3-(alkylthiobenzoyl)phenylacetic acids, esters and metal salts have the formula: ##STR1## wherein R is hydrogen or lower alkyl, R.sup.1 is hydrogen, lower alkyl or pharmaceutically acceptable metal cation, R.sup.2 is hydrogen, halogen, lower alkyl or lower alkoxy, Am is primary amino (--NH.sub.2), methylamino or dimethylamino. The compounds have anti-inflammatory activity; have effective analgesic activity, and inhibit blood platelet aggregation.
    Type: Grant
    Filed: November 22, 1983
    Date of Patent: March 5, 1985
    Assignee: A. H. Robins Company, Incorporated
    Inventors: David A. Walsh, Dwight A. Shamblee
  • Patent number: 4452809
    Abstract: Cis and trans-3-aryloxy-4-hydroxypyrrolidines and derivatives thereof having the formula: ##STR1## are disclosed wherein R.sub.1 is hydrogen, loweralkyl, benzyloxycarbonyl and N-loweralkylcarbamoyl; R.sub.2 is hydrogen, lower alkyl, cycloalkyl, phenylalkyl, benzyloxycarbonyl, carbamoyl, N-loweralkylcarbamoyl, N-diloweralkylcarbamoyl and parafluorobenzoyl-lower-alkyl; Ar is phenyl, substituted phenyl, 1-naphthyl, 2-naphthyl, 1-indenyl and 2-indenyl and pharmaceutically acceptable acid addition and quaternary salts thereof. The compounds have antidepressant, antihypertensive and antiarrythmic activity in animals.
    Type: Grant
    Filed: April 22, 1983
    Date of Patent: June 5, 1984
    Assignee: A. H. Robins Company, Inc.
    Inventors: David A. Walsh, William J. Welstead, Jr.
  • Patent number: 4440785
    Abstract: Novel 2-aminobiphenylacetic acids, esters and metal salts of the formula are disclosed: ##STR1## wherein R represents hydrogen, lower alkyl, sodium or potassium; R.sup.1 represents fluoro, chloro, bromo, lower-alkyl or amino; R.sup.2 represents lower-alkyl, lower-alkoxy, fluoro, chloro, bromo, amino or trifluoromethyl; and m and n are 0-2 with the proviso that when R.sup.1 or R.sup.2 are tertiary butyl or a sterically hindering lower alkyl radical, m and/or n are 1. The compounds are prepared by hydrolysis of 4-(5-, 6- and 7-)phenylindolin-2-ones to give the 2-amino-3-(4-, 5- and 6-)biphenylacetic acids. The free acids are converted to the esters and metal salts. The compounds have anti-inflammatory activity and inhibit blood platelet aggregation.
    Type: Grant
    Filed: January 13, 1982
    Date of Patent: April 3, 1984
    Assignee: A. H. Robins Company, Inc.
    Inventor: David A. Walsh
  • Patent number: 4333951
    Abstract: Novel 2-amino-6-biphenylacetic acids, esters, and metal salts are provided of the formula: ##STR1## wherein R represents hydrogen or lower alkyl, R.sup.1 represents fluoro, chloro, bromo, lower-alkyl or amino; R.sup.2 represents lower-alkyl, lower-alkoxy, fluoro, chloro, bromo, amino or trifluoromethyl; n is 0-3 and m is 0-2, and the pharmaceutically acceptable salts thereof. The compounds exhibit muscle relaxant activity, and are also useful as anti-inflammatory agents.
    Type: Grant
    Filed: July 2, 1980
    Date of Patent: June 8, 1982
    Assignee: A. H. Robins Company, Inc.
    Inventor: David A. Walsh
  • Patent number: 4313949
    Abstract: Novel 2-amino-3-benzoyl-phenylacetamides are provided having the formula: ##STR1## wherein R represents hydrogen or lower alkyl, R.sup.1 and R.sup.2 represent hydrogen, lower alkyl, cycloalkyl, phenyl and phenyl substituted by lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl, and R.sup.1 and R.sup.2 when taken together with the adjacent nitrogen may form a heterocyclic residue; X represents hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; Y represents hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, lower alkylthio, lower alkyloxythio or lower alkyldioxythio; Am is primary amino (--NH.sub.2), methylamino or dimethylamino, and n is 1 to 3 inclusive. The compounds exhibit anti-inflammatory, antipyretic, anti-blood platelet aggregation and analgetic pharmacological activities.
    Type: Grant
    Filed: February 17, 1981
    Date of Patent: February 2, 1982
    Assignee: A. H. Robins Company, Inc.
    Inventors: James R. Shanklin, Jr., Dwight A. Shamblee, David A. Walsh
  • Patent number: 4254146
    Abstract: 3-Benzoyl-2-nitrophenylacetic acids, metal salts, amides and esters are disclosed having the formula: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 is OH, OM, O-lower alkyl, NH.sub.2, NH-lower alkyl or N,N-dilower alkyl; X is hydrogen, halogen, lower alkyl, lower alkoxy, trifluoromethyl or nitro and M is a pharmaceutically acceptable cation or a fraction thereof when the cation is multivalent, hydrates thereof and n is 1-3 inclusive. The compounds have anti-inflammatory activity and methods and pharmaceutical compositions for use thereof are disclosed.
    Type: Grant
    Filed: October 18, 1979
    Date of Patent: March 3, 1981
    Assignee: A. H. Robins Company, Inc.
    Inventor: David A. Walsh
  • Patent number: 4254135
    Abstract: Cis and trans 3-amino-4-hydroxypyrrolidines and derivatives thereof are disclosed having the formula: ##STR1## wherein R.sub.1 is hydrogen, loweralkyl or phenylcarbonyl; R.sub.2 is hydrogen, loweralkyl, lowercycloalkyl, phenyl or phenylloweralkyl; R.sub.3 is hydrogen, loweralkyl, phenylloweralkyl, phenylcarbonyl, diphenylmethyl, 5-yl-10,11-dihydro-5H-dibenzo[a,d]cycloheptene or naphthylcarbonyl; R.sub.4 is hydrogen, loweralkyl, phenylloweralkyl or lowercycloalkyl; phenyl is optionally substituted and acid addition salts thereof. The compounds have antidepressant activity and methods and pharmaceutical compositions for use thereof are disclosed.
    Type: Grant
    Filed: October 16, 1979
    Date of Patent: March 3, 1981
    Assignee: A. H. Robins Company, Inc.
    Inventors: David A. Walsh, Dwight A. Shamblee
  • Patent number: 4251541
    Abstract: Trans isomers of 1-substituted-3-arylthio-4-hydroxypyrrolidines and derivatives thereof having the formula: ##STR1## are disclosed wherein R.sub.1 is hydrogen, lower-alkyl, --C(O)NH-lower-alkyl and --C(O)-NH-phenyl; R.sub.2 is lower-alkyl, cycloalkyl and phenylalkyl; Ar is phenyl and substituted phenyl and the pharmaceutically acceptable addition salts thereof. The compounds have antidepressant activity in animals.
    Type: Grant
    Filed: January 9, 1979
    Date of Patent: February 17, 1981
    Assignee: A. H. Robins Company, Inc.
    Inventor: David A. Walsh
  • Patent number: 4230718
    Abstract: 3,4-Epoxypyrrolidines substituted in the 1-position with alkyl, cycloalkyl and phenylalkyl are disclosed which have pharmaceutical application in cataract prevention in animals and as intermediates in preparation of trans-3-aryloxy-4-hydroxypyrrolidines. The epoxypyrrolidines are prepared by a novel route involving chlorination of pyrrolines in aqueous medium.
    Type: Grant
    Filed: January 9, 1979
    Date of Patent: October 28, 1980
    Assignee: A. H. Robins Company, Inc.
    Inventors: David A. Walsh, William J. Welstead, Jr.