Abstract: Systems and methods for detecting a composition of a binary gas mixture are provided. Such methods and systems include, with a species-dependent mass flow meter, sensing a mass flow rate of a binary gas mixture comprising gases of differing gas correction factors and, with a species-independent pressure sensor, sensing a total pressure of the binary gas mixture. An output representative of a relative concentration of one gas of the binary gas mixture is provided. The relative concentration is determined as a function of the sensed mass flow rate and the sensed total pressure.

Abstract: A composition includes a silyl hydride (having at least one silicon-bonded hydrogen atom per molecule) and a fluorinated triarylborane Lewis acid. In the method, the Lewis acid catalyzes reaction of silicon bonded hydrogen atoms from the silyl hydride and water, thereby forming a siloxane bond in the resulting product. The composition and method can be used to form siloxane intermediates and cured networks.

Abstract: In examples, a device's native input interface (e.g., a soft keyboard) may be invoked using interaction areas associated with image frames from an application, such as a game. An area of an image frame(s) from a streamed game video may be designated (e.g., by the game and/or a game server) as an interaction area. When an input event associated with the interaction area is detected, an instruction may be issued to the client device to invoke a user interface (e.g., a soft keyboard) of the client device and may cause the client device to present a graphical input interface. Inputs made to the presented graphical input interface may be accessed by the game streaming client and provided to the game instance.

Abstract: A method of developing a road conditioning monitoring model is disclosed. The method comprises utilizing vehicle sensors to collect data under controlled conditions over a road surface to develop a training data set. The training data set undergoes a data analysis to determine an absolute running mean associated with the first road surface under controlled conditions. Abnormalities in the road surface are detected by comparing the absolute running mean with the training data set. The detected abnormalities are classified to create road surface classification rules. A method of developing a road condition database is also disclosed, that comprises utilizing vehicle sensors during operation of a vehicle to collect data during the operation and feeding the data into the road conditioning monitoring model to classify the road conditions on which the vehicle is driven. A system for determining road condition impact on a vehicle is also disclosed.

Abstract: Cryosurgical devices, such as cryosurgical probes (cryoprobes) are disclosed. Some example embodiments may include an elongated shaft at least partially housing or delineating a fluid supply conduit and a fluid exhaust conduit, the elongated shaft including a distal ablation section terminating at a closed distal end, a housing at least partially circumscribing at least a portion of a proximal end of the elongated shaft and receiving or delineating at least a portion of the fluid supply conduit and a portion of the fluid exhaust conduit; and/or a flow restricting element in fluid communication with the fluid exhaust conduit, the flow restricting element regulating the flow of fluid through at least a portion of the fluid exhaust conduit.

Abstract: An automated batch sampling drilling mud management system (1) includes a portable mud measurement system (10) and a communications system (120). The portable mud measurement system (10) has one or more measurement devices (14) arranged to measure at least one property and/or characteristic of drilling mud; and a pumping system (16) arranged to pump a batch sample of drilling mud from a supply of drilling mud to the one or more measurement devices. The pumping system (16) is also able to subsequently flush the batch sample of drilling mud from the one or more measurement devices (14). The communications system (120) enables bidirectional communications between the mud management system (10) and a remote location to enable transfer of data therebetween and the exertion of control from the remote location to the mud management system (10).

Abstract: The disclosed technology relates to a ceramic composition and an article formed therefrom. A ceramic article for radio frequency applications is formed of a ceramic material having a chemical formula represented by: Bi1.0+aY2.0?a?x?2yCax+2yFe5?x?yMIVxVyO12 or Bi1.0+aY2.0?a?2yCa2yFe5?y?zVyInzO12. The ceramic material has a composition such that a normalized change in saturation magnetization (?4?Ms), defined as ?4?Ms=[(4?Ms at 20° C.)?(4?Ms at 120° C.)]/(4?Ms at 20° C.), is less than about 0.35.

Abstract: The disclosed technology relates to a ceramic composition and an article formed therefrom. A ceramic article for radio frequency applications is formed of a ceramic material having a chemical formula represented by: Bi1.0+aY2.0-a-x-2yCax+2yFe5-x-yMIVxVyO12 or Bi1.0+aY2.0-a-2yCa2yFe5-y-zVyInzO12. The ceramic material has a composition such that a normalized change in saturation magnetization (?4?Ms), defined as ?4?Ms=[(4?Ms at 20° C.)-(4?Ms at 120° C.)]/(4?Ms at 20° C.), is less than about 0.35.

Abstract: Embodiments include methods for generating automated responses to event feed items in a multiplatform collaboration system. The methods can include receiving event notifications for events generated at a respective application service of a set of applications services, rendering a set of event cards corresponding to the events, and identifying a subset of event cards that include an update to a comment field. Methods include generating, for each event card in the subset of event cards, a comment field and causing the client device to display event cards of the set of event cards in an event feed. Methods include a, in response to a user selecting a reply option in an event card, causing the client device to launch an application platform associated with the application service and generate a response interface including a pre-populated response comment.

Abstract: In various examples, natural language processing may be performed on text generated by a game to extract one or more in-game events from the game. The system (e.g., a client device and/or server) may receive the text in the form of one or more strings generated by a game application. The system may then extract one or more in-game events from the text using natural language processing. The game may include the text in a message it sends to the system (e.g., using an Application Programming Interface (API)) and/or in a game log entry or notification. The text may be generated based at least on the game determining one or more conditions are satisfied in the gameplay (e.g., victory, points scored, milestones, eliminations, item acquisition, etc.). The text may be mapped to event templates, which may then be used to extract parameters of events therefrom.

Abstract: A differential circulator comprises first and second magnets, a ground plane, a first three-port junction conductor disposed between the first magnet and the ground plane, and a second three-port junction conductor disposed between the second magnet and the ground plane. The first three-port junction conductor and the second three-port junction conductor are in the same magnetic circuit including the first and second magnets to provide substantially same pass characteristics to radio frequency signals passing through the first three-port junction conductor and the second three-port junction conductor.

Abstract: Cyanines which selectively bind to G-quadruplex DNA complexes, particularly quadruplexes expressed in cancer cells, and methods of making and using thereof are described herein. The cyanine can be a symmetrical or unsymmetrical streptocyanine, hemicyanine, closed chain cyanine, or combinations thereof. The cyanine is preferably substituted with one or more groups that minimize or prevent aggregation of the cyanine and/or inhibit binding of the cyanine to duplex DNA. One or more of the cyanines can be formulated with one or more pharmaceutical excipients and/or carrier to prepare pharmaceutical compositions suitable for administration to a patient, particular a human patient. The compounds and compositions described herein can be used to treat diseases or disorders characterized by the expression of G-quadruplex DNA, such as cancer.

Abstract: A star polymer of formula O[P1]-([X]-A[P2]-[Z]-[P3])n where O is a core; A is a polymer arm attached to the core; X is a linker molecule between the core and the polymer arm; Z is a linker molecule between the end of the polymer arm and P3; P1, P2 and P3 are each independently one or more pharmaceutically active compounds that act extracellularly or intracellularly, n is an integer number; [ ] denotes that the group is optional; and at least one of P1, P2 or P3 is present.

Abstract: A heat pump that includes a thermoelectric device(s) and a heat sink having a raised portion with a top surface for thermally coupling with a planar face of the thermoelectric device(s). The raised portion of the heat sink includes an outer periphery and a raised central region surrounded by a void region to provide more uniform thermal conductivity when clamped within an assembly. The raised central region is shaped in an any shape corresponding to a shape of uneven thermal conductivity due to clamping pressure applied to the heat sink. The void region can be substantially contiguous and entirely circumscribe the central raised region. The device can optionally include discrete supports formed of a less thermally-conductive material within the void region. The supports can be elastomeric, such as O-rings, and disposed within pockets defined within the void region.

Abstract: Biodegradable particles for delivering a nucleic acid encoding gene-editing factors or a nucleic acid associated with a therapeutic protein to a cell, and compositions, methods, systems, and kits for gene editing in vivo or ex vivo or gene therapy for treating retinal eye diseases are disclosed.

Abstract: A modular gearbox assembly for a wind turbine having improved up-tower serviceability includes a low-speed gear stage module, a separate, intermediate-speed gear stage module adjacent to the low-speed gear stage module, and a separate high-speed gear stage module adjacent to the intermediate-speed gear stage module. The gearbox assembly also includes a first flange removably connecting the intermediate and high-speed gear stage modules and a second flange removably connecting the intermediate and low-speed gear stage modules. Thus, the low-speed gear stage module converts a low-speed, high torque input from a rotor shaft of the wind turbine to a high-speed, low torque output for a generator of the wind turbine via the intermediate and high-speed gear stage modules. In addition, the first and second flanges allow for easy disassembly of the gear stage modules such that the various stages can be easily repaired, replaced, and/or inspected.

Abstract: A high energy explosive having reduced shock sensitivity for tactical weapon platforms to increase the safety margins to the warfighter if the weapon became involved in an unplanned event on the battlefield. The high energy explosive having a reduced crystalline particle size below about 30 microns, preferably 10 microns, and coated with a thermoplastic elastomer, which is capable of being compressed into a warhead configuration and attached to a weapon. The high energy explosive having a greater than 25% reduction in shock sensitivity compared to the same crystalline energetic material without undergoing size reduction prior to being coated.

Abstract: A box closure device having a first piece, a second piece, and a hub separating the first piece and second piece is provided. The first piece can have one or more engagement portions. The second piece can extend in both directions relative to the hub and is spaced from the first piece a selected amount allowing for box flaps to fit between the top piece and bottom piece. The second piece can have a blade to assist in positioning the closure device between the interior ends of two flaps. The second piece can also have a glide. In use, the user or a machine can engage the engagement portion(s) and twist the closure device so that the bottom piece is no longer aligned with a gap between the flaps thereby locking the flaps in a closed position. Lobes can be located on the ends of the second piece.

Abstract: The present invention relates to pharmaceutical compositions suitable for oral administration, and more particularly to pharmaceutical compositions, including pharmaceutical tablet compositions, containing N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide (“AZD9291”) or a pharmaceutically acceptable salt thereof, wherein such compositions comprise a certain amount of microcrystalline cellulose and at least one other pharmaceutical diluent.

Abstract: Cationic polymers having one or more anionic ligand end groups, including a new class of carboxylated branched poly(beta-amino ester)s that can self-assemble into nanoparticles for efficient intracellular delivery of different biomolecules, including a variety of proteins is disclosed.