Patents by Inventor David Y. Chien

David Y. Chien has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HCV NS4a/modified NS3 polypeptides and uses thereof
    Patent number: 10753939
    Abstract: Modified hepatitis C virus polypeptides are described. The polypeptides include the HCV NS4a domain and modified NS3 domain. The polypeptides retain conformational epitopes. HCV immunoassays including the polypeptides are also described.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: August 25, 2020
    Assignees: ORTHO-CLINICAL DIAGNOSTICS, INC., GRIFOLS WORLDWIDE OPERATIONS LIMITED, ORTHO CLINICAL DIAGNOSTICS, K.K
    Inventors: David Y. Chien, Doris Guenzi Coit, Toshiya Fujihara, Alexander Gyenes, John Andrew Hall, Angelica Medina-Selby, Jian Zheng
  • HCV NS4A/MODIFIED NS3 POLYPEPTIDES AND USES THEREOF
    Publication number: 20190271700
    Abstract: Modified hepatitis C virus polypeptides are described. The polypeptides include the HCV NS4a domain and modified NS3 domain. The polypeptides retain conformational epitopes. HCV immunoassays including the polypeptides are also described.
    Type: Application
    Filed: March 8, 2019
    Publication date: September 5, 2019
    Inventors: David Y. Chien, Doris Guenzi Coit, Toshiya Fujihara, Alexander Gyenes, John Andrew Hall, Angelica Medina-Selby, Jian Zheng
  • HCV NS4A/modified NS3 polypeptides and uses thereof
    Patent number: 10267803
    Abstract: Modified hepatitis C virus polypeptides are described. The polypeptides include the HCV NS4a domain and modified NS3 domain. The polypeptides retain conformational epitopes. HCV immunoassays including the polypeptides are also described.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: April 23, 2019
    Assignee: ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventors: David Y. Chien, Doris Guenzi Coit, Toshiya Fujihara, Alexander Gyenes, John Andrew Hall, Angelica Medina-Selby, Jian Zheng
  • HCV NS4A/MODIFIED NS3 POLYPEPTIDES AND USES THEREOF
    Publication number: 20180011096
    Abstract: Modified hepatitis C virus polypeptides are described. The polypeptides include the HCV NS4a domain and modified NS3 domain. The polypeptides retain conformational epitopes. HCV immunoassays including the polypeptides are also described.
    Type: Application
    Filed: June 22, 2015
    Publication date: January 11, 2018
    Inventors: David Y. CHIEN, Doris Guenzi COIT, Toshiya FUJIHARA, Alexander GYENES, John Andrew HALL, Angelica MEDINA-SELBY, Jian ZHENG
  • Device and method for in-line blood testing using biochips
    Patent number: 7785782
    Abstract: A device for in-line blood screening and testing using biochips is disclosed. The screening methods include nucleic acid amplification techniques and antibody/antigen assays to detect target molecules and agents indicative of infectious diseases or metabolic diseases.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: August 31, 2010
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: David Y. Chien, Bruce H. Phelps, Yiu-Lan Fong
  • Hcv Multiple Epitope Fusion Antigens With Modified Proteolytic Cleavage Sites And Uses Thereof
    Publication number: 20080299544
    Abstract: Modified HCV multiple epitope fusion antigens (MEFAs) are described. The proteins include modified sequences such that proteolytic cleavage of the MEFAs by HCV NS3 protease is inhibited. HCV immunoassays including the modified MEFAs are also described.
    Type: Application
    Filed: August 26, 2005
    Publication date: December 4, 2008
    Inventors: David Y Chien, Doris Coit, Carlos George-Nascimento, Sansan Lin, Angelica Medina-Selby, Laura Tandeske
  • Protease regulator screening assay
    Patent number: 7439040
    Abstract: A polypeptide containing an anchor region, a protease recognition site, and a detectable signal region can be produced recombinantly and directly attached to a solid support. The polypeptide is useful for screening protease regulators, especially protease inhibitors.
    Type: Grant
    Filed: August 1, 2005
    Date of Patent: October 21, 2008
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: David Y. Chien, Mark J. Selby, Kevin Shoemaker, Robert L. Warne
  • Polynucleotides encoding a multiple epitope fusion antigen for use in an HCV antigen/antibody combination assay
    Patent number: 7319144
    Abstract: The invention relates to a method of detecting HCV infection in a biological sample, the method comprising providing an immunoassay solid support, comprising an HCV anti-core antibody, an antigen comprising an HCV NS3/4a epitope, and an HCV multiple epitope fusion antigen, that can detect both HCV antigens and antibodies present in a sample. The invention also includes polynucleotides encoding multiple epitope fusion antigens for use in the assay, recombinant vectors and host cells comprising such polynucleotides, and methods of producing the multiple epitope fusion antigens.
    Type: Grant
    Filed: August 19, 2003
    Date of Patent: January 15, 2008
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • Immunoassays for anti-HCV antibodies
    Patent number: 7241879
    Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
    Type: Grant
    Filed: July 26, 2004
    Date of Patent: July 10, 2007
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • Hepatitis C viral antigen immunoassay detection systems
    Patent number: 7108967
    Abstract: Immunoassays for detecting hepatitis C virus protein and immune complexes between hepatitis C virus protein and antibodies in biological samples, methods of screening blood products for hepatitis C virus, and kits employed therefor are provided.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: September 19, 2006
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: David Y. Chien, Phillip M. Arcangel
  • Protease regulator screening assay
    Patent number: 6924122
    Abstract: A polypeptide containing an anchor region, a protease recognition site, and a detectable signal region can be produced recombinantly and directly attached to a solid support. The polypeptide is useful for screening protease regulators, especially protease inhibitors.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: August 2, 2005
    Assignee: Chiron Corporation
    Inventors: David Y. Chien, Mark J. Selby, Kevin Shoemaker, Robert L. Warne
  • Immunoassays for anti-HCV antibodies
    Publication number: 20040265801
    Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
    Type: Application
    Filed: July 26, 2004
    Publication date: December 30, 2004
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • Hepatitis C viral antigen immunoassay detection systems
    Publication number: 20040229218
    Abstract: Immunoassays for detecting hepatitis C virus protein and immune complexes between hepatitis C virus protein and antibodies in biological samples, methods of screening blood products for hepatitis C virus, and kits employed therefor are provided.
    Type: Application
    Filed: April 7, 2004
    Publication date: November 18, 2004
    Applicant: Chiron Corporation
    Inventors: David Y. Chien, Phillip Arcangel
  • Hepatitis C viral antigen immunoassay detection systems
    Patent number: 6815160
    Abstract: Imnunoassays for detecting hepatitis C virus protein and immune complexes between hepatitis C virus protein and antibodies in biological samples, methods of screening blood products for hepatitis C virus, and kits employed therefor are provided.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: November 9, 2004
    Assignee: Chiron Corporation
    Inventors: David Y. Chien, Phillip Arcangel
  • Multiple fusion antigens for use in immunoassays for anti-HCV antibodies
    Patent number: 6797809
    Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
    Type: Grant
    Filed: August 8, 2003
    Date of Patent: September 28, 2004
    Assignee: Chiron Corporation
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • HCV antigen/antibody combination assay
    Publication number: 20040096822
    Abstract: An HCV core antigen and NS3/4a antibody combination assay that can detect both HCV antigens and antibodies present in a sample using a single solid matrix, is provided, as well as immunoassay solid supports for use in the assay.
    Type: Application
    Filed: August 19, 2003
    Publication date: May 20, 2004
    Applicant: Chiron Corporation
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • Immunoassays for anti-HCV antibodies
    Publication number: 20040063092
    Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
    Type: Application
    Filed: August 8, 2003
    Publication date: April 1, 2004
    Applicant: Chiron Corporation
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • Immunoassays for anti-HCV antibodies
    Patent number: 6632601
    Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: October 14, 2003
    Assignee: Chiron Corporation
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • HCV antigen/antibody combination assay
    Patent number: 6630298
    Abstract: An HCV core antigen and NS3/4a antibody combination assay that can detect both HCV antigens and antibodies present in a sample using a single solid matrix, is provided, as well as immunoassay solid supports for use in the assay.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: October 7, 2003
    Assignee: Chiron Corporation
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • Buffers for stabilizing antigens
    Publication number: 20030170618
    Abstract: The present invention is directed to an antigen diluent or buffer for antigens, in particular HCV recombinant antigens, comprising a reducing agent. The antigen diluent or buffer serves as a stabilizing buffer for the antigens. The present invention is also directed to antigen diluents or buffers for use in an automated immunoassay.
    Type: Application
    Filed: January 28, 2003
    Publication date: September 11, 2003
    Inventors: David Y. Chien, Phillip Arcangel, Stephen Tirell, Wanda Zeigler