Patents by Inventor Dean S. Burgi

Dean S. Burgi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210277445
    Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.
    Type: Application
    Filed: December 11, 2020
    Publication date: September 9, 2021
    Inventors: David Eberhart, Yuan Li, James Ogg, Ezra Van Gelder, Stephen J. Williams, Timothy Woudenberg, Dean S. Burgi, William D. Nielsen
  • Patent number: 10865440
    Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: December 15, 2020
    Assignee: IntegenX, Inc.
    Inventors: David Eberhart, Yuan Li, James Ogg, Ezra Van Gelder, Stephen J. Williams, Timothy Woudenberg, Dean S. Burgi, William D. Nielsen
  • Publication number: 20150285766
    Abstract: Methods of electrokinetic chromatograph that produce focusing of an analyte. This may be done by creating an electroosmotic flow gradient in the background electrolyte near the sample matrix.
    Type: Application
    Filed: April 2, 2015
    Publication date: October 8, 2015
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Braden C. Giordano, Dean S. Burgi
  • Publication number: 20150024436
    Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.
    Type: Application
    Filed: February 28, 2013
    Publication date: January 22, 2015
    Applicant: INTEGENX INC,
    Inventors: David Eberhart, Yuan Li, James Ogg, Ezra Van Gelder, Stephen J. Williams, Timothy Woudenberg, Dean S. Burgi, William D. Nielsen
  • Patent number: 5736025
    Abstract: A gel electrophoresis separation apparatus comprising, in combination, a gaseous heat-exchange medium, a gaseous heat-exchange medium driving means, and an impingement means, whereby the gaseous heat-exchange medium is driven by the gaseous heat-exchange medium driving means across the impingement means to provide a flow of the gaseous heat-exchange medium on the surface of the gel plates, whereby the flow induced by passage of the gaseous heat-exchange medium through the impingement means thereby minimizes temperature gradients within the gel by forced convection.
    Type: Grant
    Filed: November 7, 1996
    Date of Patent: April 7, 1998
    Assignee: Genomyx Inc.
    Inventors: Douglas H. Smith, Brian J. Mifsud, Dean S. Burgi, Thomas E. Davis, Steven M. VanHuystee
  • Patent number: 5666435
    Abstract: A system for identification of DNA bases in a nucleotide sequence includes a microprocessor and a set of executable instructions and is configured to accept a set of input data corresponding to a DNA sequence image from an autoradiograph. In part by interpolating a distribution of density peaks derived from the set of input data, the system is configured to generate a set of output data substantially identifying or presenting the bases in the DNA sequence in a linear fashion, corresponding to the linear order of nucleotides comprising the DNA sequence. The system thereby enables identification of substantially more bases than could be read by the human eye. Enhanced electrophoresis equipment and consumables may also be applied to generate a more predictable and linear set of input data and, in turn, to generate a set of output data identifying an even greater number of DNA bases in the sequence under analysis.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: September 9, 1997
    Assignee: Genomyx Corporation
    Inventors: Dean S. Burgi, Daniel M. Bartell, Donald D. Sleeter, Lucina P. Mastro
  • Patent number: 5560125
    Abstract: A method for drying electrophoresis gel comprising, in combination, using a gaseous moisture removing medium, a gaseous moisture removing medium driving means, and an impingement means, whereby the gaseous moisture removing medium is driven by the gaseous moisture removing medium driving means across the impingement means to provide a flow of the gaseous moisture removing medium on the surface of the gel plates, whereby the flow induced by passage of the gaseous moisture removing medium through the impingement means thereby minimizes temperature gradients within the gel by forced convection and reduces drying time of the gel.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: October 1, 1996
    Assignee: Genomyx Corporation
    Inventor: Dean S. Burgi
  • Patent number: 5385654
    Abstract: An improved method for the separation of anions using capillary electrophoresis techniques. Both organic and inorganic anions may be separated. Using precise control of the temperature of the fluid in the capillary column; the migration speed and order of migration of the anions may be controlled to improve the selectivity of the process. Further, close temperature control provides a high degree of repeatability for samples and enables one to track and identify specific anions.
    Type: Grant
    Filed: July 7, 1993
    Date of Patent: January 31, 1995
    Assignee: Thermo Separation Products Inc.
    Inventors: Lenore Kelly, Dean S. Burgi, Robert J. Nelson
  • Patent number: 5235409
    Abstract: On-column optical detection apparatus and method for use with capillary separation columns are shown. The apparatus and method minimize the adverse effects of light scattered from the walls of the column, thereby improving detection sensitivity and providing greater dynamic range. Light from a conventional source is focussed onto a column. Spatial filter means are positioned in front of the column to prevent at least some light from striking the column wall. Another spatial filter is positioned in front of a light collecting means which gathers light emanating from the column. In a specific embodiment, a unique monolens design is shown comprising collecting and focussing lens formed as an integral unit with a bore for a capillary column.
    Type: Grant
    Filed: August 13, 1991
    Date of Patent: August 10, 1993
    Assignee: Varian Associates, Inc.
    Inventors: Dean S. Burgi, John C. Helmer, Ring-Ling Chien
  • Patent number: 5116471
    Abstract: The method for improving sample concentration in capillary electrophoresis by extracting the sample buffer from the capillary column using the electro-osmotic flow while the sample components are stacked into the support buffer utilizes a system for this technique. The system has a separation column 11, sample introduction means 16 for injecting the sample solution, an injection detector means 20 for detecting the volume of injected sample solution, a separation detector means 21 for detecting the sample components, power supply means 17 for applying a high voltage along the separation column 11 for reversing the direction of the electro-osmotic flow thereby causing extraction of the sample buffer from the separation column and afterward providing the separation sample into its components.
    Type: Grant
    Filed: October 4, 1991
    Date of Patent: May 26, 1992
    Assignee: Varian Associates, Inc.
    Inventors: Ring-Ling Chien, Dean S. Burgi
  • Patent number: 5089099
    Abstract: An improved electroinjection method of introducing a sample having positive and negative ions into a capillary column for CE or CZE process by introducing a short plug of a low concentration buffer before introducing the sample into the column which results in increasing amount of charged ions of the sample introduced in the capillary column due to increasing the electric field at the injection point. A method for efficiently introducing both positive and negative ions is also shown.
    Type: Grant
    Filed: November 30, 1990
    Date of Patent: February 18, 1992
    Assignee: Varian Associates, Inc.
    Inventors: Ring-Ling Chien, Dean S. Burgi