Patents by Inventor Debra A. Ross
Debra A. Ross has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7767627Abstract: Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials or, alternatively, allowing the components to interact to form at least two different materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, nonbiological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc.Type: GrantFiled: April 22, 1997Date of Patent: August 3, 2010Assignees: Symyx Solutions, Inc., The Regents of the University of CaliforniaInventors: Isy Goldwasser, Debra A. Ross, Peter G. Schultz, Xiao-Dong Xiang, Gabriel BriceƱo, Xian-Dong Sun, Kai-An Wang
-
Patent number: 7736906Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodologies.Type: GrantFiled: June 17, 2002Date of Patent: June 15, 2010Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
-
Patent number: 7691330Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.Type: GrantFiled: May 26, 2000Date of Patent: April 6, 2010Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
-
Patent number: 6943034Abstract: A method for producing arrays by spacing a dispenser a distance from a surface of a support, dispensing a volume containing a compound in a single coupling step of less than 5 nl to occupy a localized area of less than 1 cm2 of the surface of the support, allowing the compound to bind directly or indirectly to the support and repeating the steps to produce an array of at least 100 ligands at a density of 1000 per cm2 or greater.Type: GrantFiled: February 4, 2000Date of Patent: September 13, 2005Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
-
Publication number: 20050186683Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.Type: ApplicationFiled: November 24, 2004Publication date: August 25, 2005Applicants: Affymetrix, Inc., AFFYMAX TECHNOLOGIES N.V.Inventors: James Winkler, Stephen Fodor, Christopher Buchko, Debra Ross, Lois Aldwin, Douglas Modlin
-
Publication number: 20050186592Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.Type: ApplicationFiled: November 24, 2004Publication date: August 25, 2005Applicants: Affymetrix, Inc., AFFYMAX TECHNOLOGIES N.V.Inventors: James Winkler, Stephen Fodor, Christopher Buchko, Debra Ross, Lois Aldwin, Douglas Modlin
-
Publication number: 20050124000Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.Type: ApplicationFiled: November 24, 2004Publication date: June 9, 2005Applicants: Affymetrix, Inc., AFFYMAX TECHNOLOGIES N.V., a Netherlands Antilles corporationInventors: James Winkler, Stephen Fodor, Christopher Buchko, Debra Ross, Lois Aldwin, Douglas Modlin
-
Patent number: 6864101Abstract: A method for producing polymer arrays by spacing a dispenser a distance from a surface of a support, dispensing a volume containing a monomer in a single coupling step of less than 5 nl to occupy a localized area of less than 1 cm2 of the surface of the support, allowing the monomer to bind directly or indirectly to the support and repeating the steps to produce an array of at least 100 polymer ligands at a density of 1000 per cm2 or greater.Type: GrantFiled: May 26, 2000Date of Patent: March 8, 2005Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
-
Patent number: 6849462Abstract: A method for producing arrays by depositing a resist on a substrate, selectively removing a portion of the resist to expose localized areas, dispensing a monomer to occupy a localized area of less than 1 cm2 of the surface of the support, allowing the monomer to bind directly or indirectly to the support and repeating the steps to produce an array of at least 10 different polymers is formed.Type: GrantFiled: May 26, 2000Date of Patent: February 1, 2005Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
-
Publication number: 20040092032Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.Type: ApplicationFiled: June 17, 2002Publication date: May 13, 2004Applicant: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P.A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
-
Patent number: 6136269Abstract: A device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.Type: GrantFiled: April 21, 1995Date of Patent: October 24, 2000Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
-
Patent number: 6040193Abstract: An array is created by moving a dispenser toward a solid support until a tip of the dispenser touches the support, withdrawing the tip from the surface and releasing a drop of 5 nanoliters or less in an area smaller than 1 mm.sup.2 to create an array of at least 100 spots.Type: GrantFiled: August 4, 1998Date of Patent: March 21, 2000Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
-
Patent number: 5885837Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are flowed through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.Type: GrantFiled: October 23, 1996Date of Patent: March 23, 1999Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin
-
Patent number: 5677195Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.Type: GrantFiled: November 20, 1992Date of Patent: October 14, 1997Assignee: Affymax Technologies N.V.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
-
Patent number: 5529752Abstract: This invention encompasses a work station for conducting assays which comprises filtering assembly, a slide reading assembly, and a slide with a porous filter membrane wherein the slide has a means for aligning the slide within the filter assembly to filter reagents on predetermined portions of the porous filter membrane and also to position the slide in the slide reading assembly so that detection will occur in those same predetermined locations.Type: GrantFiled: December 22, 1994Date of Patent: June 25, 1996Assignee: Molecular Devices CorporationInventors: George Pontis, Michael Lacy, Vladimir Drbal, Calvin Chow, Thomas Smith, Rick Smethers, Debra A. Ross, Gregory Kirk, Jonathan Briggs, Lev Leytes, Suresh N. Mehta
-
Patent number: 5384261Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are flowed through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.Type: GrantFiled: November 22, 1991Date of Patent: January 24, 1995Assignee: Affymax Technologies N.V.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin
-
Patent number: 5252293Abstract: This invention encompasses a slide reading assembly, and a slide with a porous filter membrane wherein the slide has a means for aligning the slide within a filter assembly to filter reagents on predetermined portions of the porous filter membrane and also to position the slide in a slide reading assembly so that detection will occur in those same predetermined locations.Type: GrantFiled: January 17, 1989Date of Patent: October 12, 1993Inventors: Vladimir Drbal, Calvin Chow, Rick Smethers, Debra A. Ross, Gregory Kirk, Briggs, Jonathan, Lev Leytes, Suresh N. Mehta