Patents by Inventor Deepti ROKKAM

Deepti ROKKAM has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL12 receptor synthetic cytokines and methods of use
    Patent number: 12291572
    Abstract: Provided herein are IL12R binding molecules that bind to IL12Rb1 and IL12Rb2 and comprise an anti-IL12Rb2 sdAb and an anti-IL12Rb2 VHH antibody.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: May 6, 2025
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Deepti Rokkam, Patrick J. Lupardus
  • IL10RB binding molecules and encoding nucleic acids
    Patent number: 12286482
    Abstract: The present disclosure relates to biologically active molecules comprising a single domain antibody (sdAb) that specifically binds to the extracellular domain of human IL10Rb, compositions comprising such antibodies, and methods of use thereof.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: April 29, 2025
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Sandro Vivona, Deepti Rokkam, Patrick J. Lupardus
  • IL2RB binding molecules and methods of use
    Patent number: 12234291
    Abstract: The present disclosure relates to biologically active molecules comprising a single domain antibody (sdAb) that specifically binds to the extracellular domain of IL2Rb, compositions comprising such antibodies, and methods of use thereof.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: February 25, 2025
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Deepti Rokkam, Patrick J. Lupardus, Sandro Vivona
  • Compositions and methods related to IL27 receptor binding
    Patent number: 12209132
    Abstract: Provided herein are IL27R binding proteins that bind to IL27R? and gp130 and comprise an anti-IL27R? VHH antibody and an anti-gp130 VHH antibody.
    Type: Grant
    Filed: September 11, 2023
    Date of Patent: January 28, 2025
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Patrick Lupardus, Deepti Rokkam
  • IL2RB/IL2G SYNTHETIC CYTOKINES
    Publication number: 20250019453
    Abstract: Provided herein are IL2R binding molecules that bind to IL2Rb and IL2Rg and comprise an IL2Rg sdAb and an anti-IL2Rg VHH antibody.
    Type: Application
    Filed: August 9, 2024
    Publication date: January 16, 2025
    Inventors: Robert Kastelein, Deepti Rokkam, Patrick J. Lupardus, Rene De Waal Malefyt, Sandro Vivona
  • IL27RAlpha binding molecules and methods of use
    Patent number: 12157773
    Abstract: The present disclosure relates to biologically active molecules comprising a single domain antibody (sdAb) that specifically binds to the extracellular domain of human IL27R?, compositions comprising such antibodies, and methods of use thereof.
    Type: Grant
    Filed: August 4, 2021
    Date of Patent: December 3, 2024
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Deepti Rokkam, Patrick J. Lupardus, Sandro Vivona
  • IL23R BINDING MOLECULES AND METHODS OF USE
    Publication number: 20240376217
    Abstract: The present disclosure relates to biologically active molecules comprising a single domain antibody (sdAb) that specifically binds to the extracellular domain of human IL23R, compositions comprising such antibodies, and methods of use thereof.
    Type: Application
    Filed: May 6, 2024
    Publication date: November 14, 2024
    Inventors: Robert Kastelein, Patrick J. Lupardus, Deepti Rokkam
  • IL10 receptor binding molecules and methods of use
    Patent number: 12139545
    Abstract: Provided herein are IL10R binding molecules that bind to IL10Ra and IL10Rb and comprise an IL10Rb sdAb and an IL10Rb VHH antibody.
    Type: Grant
    Filed: February 3, 2023
    Date of Patent: November 12, 2024
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Mahalakshmi Ramadass, Deepti Rokkam, Patrick J. Lupardus, Sandro Vivona
  • IFNGR binding synthetic cytokines and methods of use
    Patent number: 12122839
    Abstract: Provided herein are IFNGR binding molecules that bind to IFNGR1 and IFNGR2 and comprise an anti-IFNGR2 sdAb and an anti-IFNGR2 VHH antibody.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: October 22, 2024
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Deepti Rokkam, Patrick J. Lupardus
  • Heterodimeric Fc cytokines and uses thereof
    Patent number: 12103954
    Abstract: The present disclosure provides IL12 and IL23 muteins as partial agonists comprising modified human p40 molecules that associate with human p35 (hP35) and human P19 (hP19) to form modified hIL-12 and IL23 partial agonists wherein the individual components of IL12 and IL23 muteins are linked to engineered Fc domains.
    Type: Grant
    Filed: February 20, 2024
    Date of Patent: October 1, 2024
    Assignee: Synthekine, Inc.
    Inventors: Patrick Lupardus, Deepti Rokkam
  • IL2RG binding molecules and methods of use
    Patent number: 12077594
    Abstract: The present disclosure relates to biologically active molecules comprising a single domain antibody (sdAb) that specifically binds to the extracellular domain of human IL2Rg, compositions comprising such antibodies, and methods of use thereof.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: September 3, 2024
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Deepti Rokkam, Patrick J. Lupardus, Sandro Vivona
  • HETERODIMERIC FC CYTOKINES AND USES THEREOF
    Publication number: 20240209049
    Abstract: The present disclosure provides IL12 and IL23 muteins as partial agonists comprising modified human p40 molecules that associate with human p35 (hP35) and human P19 (hP19) to form modified hIL-12 and IL23 partial agonists wherein the individual components of IL12 and IL23 muteins are linked to engineered Fc domains.
    Type: Application
    Filed: February 20, 2024
    Publication date: June 27, 2024
    Inventors: Patrick Lupardus, Deepti Rokkam
  • COMPOSITIONS AND METHODS RELATED TO IL27 RECEPTOR BINDING
    Publication number: 20240209101
    Abstract: Provided herein are IL27R binding proteins that bind to IL27R? and gp130 and comprise an anti-IL27R? VHH antibody and an anti-gp130 VHH antibody.
    Type: Application
    Filed: September 11, 2023
    Publication date: June 27, 2024
    Inventors: Robert Kastelein, Patrick Lupardus, Deepti Rokkam
  • Interferon-gamma R2 (IFNGR2) binding molecules comprising single-domain antibodies and method of use thereof to treat autoimmune and inflammatory diseases
    Patent number: 12018085
    Abstract: The present disclosure relates to biologically active molecules comprising a single domain antibody (sdAb) that specifically binds to the extracellular domain of human IFNgR2, compositions comprising such antibodies, and methods of use thereof.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: June 25, 2024
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Patrick J. Lupardus, Deepti Rokkam
  • GP130 Binding Molecules and Methods of Use
    Publication number: 20240199737
    Abstract: The present disclosure relates to biologically active molecules comprising a single domain antibody (sdAb) that specifically binds to the extracellular domain of human gp130, compositions comprising such antibodies, and methods of use thereof.
    Type: Application
    Filed: August 4, 2021
    Publication date: June 20, 2024
    Inventors: Robert Kastelein, Deepti Rokkam, Patrick J. Lupardus, Sandro Vivona
  • IL23R binding molecules and methods of use
    Patent number: 12012457
    Abstract: The present disclosure relates to biologically active molecules comprising a single domain antibody (sdAb) that specifically binds to the extracellular domain of human IL23R, compositions comprising such antibodies, and methods of use thereof. Further disclosed are sequences of complementarity determining regions (CDR1, CDR2 and CDR3) and polypeptide sequences of human and mouse sdAbs.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: June 18, 2024
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Patrick J. Lupardus, Deepti Rokkam
  • IL12RB1-BINDING MOLECULES AND METHODS OF USE
    Publication number: 20240166754
    Abstract: The present disclosure relates to biologically active molecules comprising a single comain antibody (sdAb) that specifically binds to the extracellular domain of human IL12RM, compositions comprising such antibodies, and methods of use thereof.
    Type: Application
    Filed: November 20, 2023
    Publication date: May 23, 2024
    Inventors: Robert Kastelein, Deepti Rokkam, Patrick Lupardus, Sandro Vivona
  • HETERODIMERIC FC CYTOKINES AND USES THEREOF
    Publication number: 20240132562
    Abstract: The present disclosure provides IL12 and IL23 muteins as partial agonists comprising modified human p40 molecules that associate with human p35 (hP35) and human P19 (hP19) to form modified hIL-12 and IL23 partial agonists wherein the individual components of IL12 and IL23 muteins are linked to engineered Fc domains.
    Type: Application
    Filed: November 21, 2023
    Publication date: April 25, 2024
    Inventors: Patrick Lupardus, Deepti Rokkam
  • COMPOSITIONS AND METHODS RELATED TO RECEPTOR PAIRINGS
    Publication number: 20240026014
    Abstract: Provided herein are receptor binding proteins that bind to either natural cytokine receptor pairs or non-natural cytokine receptor pairs to create signaling diversity beyond natural receptor pairings.
    Type: Application
    Filed: August 5, 2021
    Publication date: January 25, 2024
    Inventors: Robert Kastelein, Patrick J. Lupardus, Deepti Rokkam
  • Compositions and methods related to IL27 receptor binding
    Patent number: 11873349
    Abstract: Provided herein are IL27R binding proteins that bind to IL27R? and gp130 and comprise an anti-IL27R? VHH antibody and an anti-gp130 VHH antibody.
    Type: Grant
    Filed: February 3, 2023
    Date of Patent: January 16, 2024
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Patrick Lupardus, Deepti Rokkam