Abstract: Provided herein are 4-aminoisoindoline-1,3-dione compounds having the following structure: wherein R, Ring A, and n are as defined herein, compositions comprising an effective amount of a 4-aminoisoindoline-1,3-dione compound, and methods for treating or preventing disorders.

Abstract: Provided herein are compounds and compositions thereof for modulating BCL6. In some embodiments, the compounds and compositions are provided for treatment of cancer or an autoimmune disease.

Abstract: A method is given for a broadband constant beam width acoustic array using shading function parameters for a three dimensional axially symmetric beam. Coefficients are calculated for an estimated shading function fitting the parameters that is a summation of Legendre polynomial orders. The number of orders is user specified. Null bearing locations can be determined from the parameters or from the shading function. A constant beam width shading function can be created from these parameters and used as amplifications and attenuations for a conical spherical array of transducers. The array can be truncated at the null bearing locations. The estimated shading function can be further refined by provided additional Legendre polynomial orders.

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein R1, R2, R3, R4, L, V, X, a and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: A method is given for a broadband constant beam width acoustic array using shading function parameters for a three dimensional axially symmetric beam. Coefficients are calculated for an estimated shading function fitting the parameters that is a summation of Legendre polynomial orders. The number of orders is user specified. Null bearing locations can be determined from the parameters or from the shading function. A constant beam width shading function can be created from these parameters and used as amplifications and attenuations for a conical spherical array of transducers. The array can be truncated at the null bearing locations. The estimated shading function can be further refined by provided additional Legendre polynomial orders.

Abstract: An LED bulb without driving power supply includes a lamp cap, a bulb shell, a current limiting resistor, a core column, and an LED filament. The two ends of the LED filament are provided with connection terminals, the substrate of the LED filament is provided with two conductive lines, the two ends of the conductive line are respectively connected to the connection terminal through rectifier diodes. The rectifier diodes at both ends of the same conductive line are arranged in the opposite direction, and the rectifier diodes connecting different conductive lines on the same connection terminal are arranged in the opposite direction. The LED bulb can be directly connected to the external alternating current power supply to light the lighting without a driving power supply, which eliminates the cost of installing the driving power supply.

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein R1, R2, R3, R4, L, V, X, a and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: A method for providing a broadband constant beam width acoustic array includes providing a transducer array in an axisymmetric configuration. A beam width is specified, and an integer order Legendre polynomial is determined for that beam width. A control parameter is determined that will increase the integer order Legendre polynomial to that beam width. The Legendre polynomial is used to provide a shading function for the array of transducers that will give the specified beam width.

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein RN, R1, R2, R3, R4, RN, L, V, X, a, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein RN, R1, R2, R3, R4, RN, L, V, X, a, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein R1, R2, R3, R4, L, V, X, A, A?, a and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: Provided herein are 4-aminoisoindoline-1,3-dione compounds having the following structure: wherein R, Ring A, and n are as defined herein, compositions comprising an effective amount of a 4-aminoisoindoline-1,3-dione compound, and methods for treating or preventing disorders.

Abstract: A method for calibrating an acoustic calibration tank providing the tanks with reference hydrophones positioned along the tank. The tank is filled with a fluid at a known temperature and pressure. A calibrated reverse hydrophone is positioned in the tank, opposite one of the reference hydrophones. A known acoustic wave is created in the tank using the calibrated reverse hydrophone and the opposite reference hydrophone output is measured. Free field voltage sensitivity is computed for the reference hydrophone. This gives the calibration factor for the reference hydrophone. The calibrated reverse hydrophone can be repositioned. An iterative process can be utilized for the other reference hydrophones, and other known pressures and temperatures.

Abstract: Provided herein are 4-aminoisoindoline-1,3-dione compounds having the following structure: wherein R, Ring A, and n are as defined herein, compositions comprising an effective amount of a 4-aminoisoindoline-1,3-dione compound, and methods for treating or preventing disorders.

Abstract: An LED bulb without driving power supply includes a lamp cap, a bulb shell, a current limiting resistor, a core column, and an LED filament. The two ends of the LED filament are provided with connection terminals, the substrate of the LED filament is provided with two conductive lines, the two ends of the conductive line are respectively connected to the connection terminal through rectifier diodes. The rectifier diodes at both ends of the same conductive line are arranged in the opposite direction, and the rectifier diodes connecting different conductive lines on the same connection terminal are arranged in the opposite direction. The LED bulb can be directly connected to the external alternating current power supply to light the lighting without a driving power supply, which eliminates the cost of installing the driving power supply.

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein R1, R2, R3, R4, L, V, X, A, A?, a and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein R1, R2, R3, R4, L, V, X, a and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein RN, R1, R2, R3, R4, RN, L, V, X, a, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.