Abstract: The present disclosure concerns a membrane-less electrolyzer comprising a first electrode and a second electrode, a first fluidic channel configured to receive an electrolyte, a second fluidic channel configured to receive the electrolyte from the first fluidic channel, a third fluidic channel configured to receive the electrolyte from the first fluidic channel. The first fluidic channel being in fluidic communication with the second and third fluidic channels. The first fluidic channel is connected to the second and third fluidic channels via a plurality of inclined fluidic canals extending from the first fluidic channel to each of the second and third fluidic channels.

Abstract: A method for visualizing structures inside a cochlea, comprising the steps of irradiating a cochlear bone with a first laser light to ablate portions of the cochlear bone, to form a thinned area of the cochlear bone, and imaging intracochlear structures by a second light via the thinned area of the cochlear bone to optically scan targeted structures inside the cochlea.

Abstract: A retinal projector system, comprising a coupling means, a spacial light modulator, and a tapered optical waveguide having an input side surface and an output side surface, whereby the input side surface is larger than the output side surface, the coupling means being configured to couple coherent light into the spatial light modulator, the spacial light modulator being configured to receive the coherent light and output modulated light modulated in 2 dimensions towards the input side surface, the tapered optical waveguide being configured to guide the modulated light received at the input side surface and reduce a size of the tapered optical waveguide towards the output side surface, without losing any information from the modulated light at the output side surface such to allow an image formation.

Abstract: The present invention concerns a membrane-less electrolyzer comprising a fluidic channel for receiving an electrolyte fluid; a first electrode and a second electrode located inside the fluidic channel, the first and second electrode permitting to extract a first gas and a second gas inside the fluidic channel from the electrolyte fluid, the first electrode and second electrode being separated by solely a surrounding fluid in the fluidic channel or the electrolyte; and a first fluidic transport channel for transporting the first gas to a first outlet and a second fluidic transport channel for transporting the second gas to a second outlet.

Abstract: The present invention relates to polymeric structures, in the form of flat membrane-like surfaces or micro- nanostruc-tures such as capsules, characterized in that it comprises a substantially two-dimensional layer of covalently-bonded monomers of R-substituted metal or metalloid oxides. Said polymeric structures in most embodiments have a crystal architecture with a hexagonal lattice, but the nature of the covalent bonds present therein impart a bending flexibility that make the polymeric structures behave as a “soft” crystal. Methods of producing such structures, composition comprising thereof and method of using thereof are also included within the present disclosure.

Abstract: A retinal projector system, comprising a coupling means, a spacial light modulator, and a tapered optical waveguide having an input side surface and an output side surface, whereby the input side surface is larger than the output side surface, the coupling means being configured to couple coherent light into the spatial light modulator, the spacial light modulator being configured to receive the coherent light and output modulated light modulated in 2 dimensions towards the input side surface, the tapered optical waveguide being configured to guide the modulated light received at the input side surface and reduce a size of the tapered optical waveguide towards the output side surface, without losing any information from the modulated light at the output side surface such to allow an image formation.

Abstract: A method for visualizing structures inside a cochlea, comprising the steps of irradiating a cochlear bone with a first laser light to ablate portions of the cochlear bone, to form a thinned area of the cochlear bone, and imaging intracochlear structures by a second light via the thinned area of the cochlear bone to optically scan targeted structures inside the cochlea.

Abstract: The design of a proximity sensor to be integrated into cochlea implants is described. The sensor allows the anticipation of contact between the cochlear implant and intracochlear structures, including the cochlear canal wall and basilar membrane, providing a feedback or an alarm to the surgeon performing the implant insertion such that trauma to the cochlea is avoided. This helps to preserve any residual hearing ability in patients who receive the surgical implant.

Abstract: Systems and methods for imaging ear tissue include: directing illumination radiation to pass through an intact biological structure and be incident on ear tissue that does not include an exogenous fluorophore, at a plurality of locations, the illumination radiation including a plurality of light pulses each having a temporal duration of 500 femtoseconds or less; for each one of the plurality of locations, using a detector to detect radiation emitted from the location that passes through the intact biological structure; and forming an image of the tissue based on the detected radiation at each of the plurality of locations, where the emitted radiation corresponds to endogenous two-photon fluorescence of the tissue.

Abstract: A bending compensation device for a waveguide, including a direction changing device configured to maintain a constant bending angle to the waveguide, a distal end of the waveguide having a first orientation, and the proximal end of the waveguide having a second orientation, and a motion device connected to the direction changing device, the motion device configured to move the direction changing device upon a movement of the waveguide.

Abstract: Second harmonic nanoprobes for imaging biological samples and a method of using such probes to monitor the dynamics of biological process using a field resonance enhanced second harmonic (FRESH) technique are provided. The second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystals that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy for in vivo imaging of biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging.

Abstract: A multimode waveguide illuminator and imager relies on a wave front shaping system that acts to compensate for modal scrambling and light dispersion by the multimode waveguide. A first step consists of calibrating the multimode waveguide and a second step consists in projecting a specific pattern on the wave guide proximal end in order to produce the desire light pattern at its distal end. The illumination pattern can be scanned or changed dynamically only by changing the phase pattern projected at the proximal end of the waveguide. The third and last step consists in collecting the optical information, generated by the sample, through the same waveguide in order to form an image. Known free space microscopy technique can be adapted to endoscopy with multimode waveguide, such as, but not limited to, fluorescence imaging or Raman spectros copy or imaging, 3D linear scattering imaging or two-photon imaging. Super-resolution, i.e.

Abstract: The present invention concerns a membrane-less electrolyzer comprising a fluidic channel for receiving an electrolyte fluid; a first electrode and a second electrode located inside the fluidic channel, the first and second electrode permitting to extract a first gas and a second gas inside the fluidic channel from the electrolyte fluid, the first electrode and second electrode being separated by solely a surrounding fluid in the fluidic channel or the electrolyte; and a first fluidic transport channel for transporting the first gas to a first outlet and a second fluidic transport channel for transporting the second gas to a second outlet.

Abstract: The present invention relates to polymeric structures, in the form of flat membrane-like surfaces or micro- nanostruc-tures such as capsules, characterized in that it comprises a substantially two-dimensional layer of covalently-bonded monomers of R-substituted metal or metalloid oxides. Said polymeric structures in most embodiments have a crystal architecture with a hexagonal lattice, but the nature of the covalent bonds present therein impart a bending flexibility that make the polymeric structures behave as a “soft” crystal. Methods of producing such structures, composition comprising thereof and method of using thereof are also included within the present disclosure.

Abstract: Second harmonic nanoprobes for imaging biological samples and a method of using such probes to monitor the dynamics of biological process using a field resonance enhanced second harmonic (FRESH) technique are provided. The second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystals that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy for in vivo imaging of biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging.

Abstract: A drop delivery system comprising a light source; an optical waveguide bringing light from the light source; and a liquid supplying means configured to bring a liquid at a tip of the optical waveguide, wherein the light source and the optical waveguide are configured to enable the light to eject a drop of the liquid.

Abstract: A bending compensation device for a waveguide, including a direction changing device configured to maintain a constant bending angle to the waveguide, a distal end of the waveguide having a first orientation, and the proximal end of the waveguide having a second orientation, and a motion device connected to the direction changing device, the motion device configured to move the direction changing device upon a movement of the waveguide.

Abstract: Second harmonic nanoprobes for imaging biological samples and a method of using such probes to monitor the dynamics of biological process using a field resonance enhanced second harmonic (FRESH) technique are provided. The second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystals that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy for in vivo imaging of biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging.

Abstract: A device having a water vapor microelectrolyzer cell including microstructured parallel electrodes where the water splitting reactions can take place, the microstructured electrodes being covered by a thin layer of solid-state ion conducting material to allow for the conduction of protons during the device operation, while permitting the diffusion of water from the vapor phase into the electrodes, as well as the diffusion of evolved oxygen and hydrogen gases from the electrodes into the vapor phase environment above the ion-conductor film.

Abstract: An endoscopic device for photoacoustic imaging, including a multimode optical fiber having a distal end and a proximal end, a light source to provide a light beam to the proximal end of the multimode optical fiber, a transducer to capture acoustic waves that are emitted from the proximal end of the multimode optical fiber, and a processing device to generate a photoacoustic image based on data from the captured acoustic waves captured by the transducer, wherein the distal end of the multimode optical fiber is configured to be inserted into a sample, the sample generating the acoustic waves by a photoacoustic effect.