Patents by Inventor Denis Billen

Denis Billen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS OF MAKING A CRYSTALLINE EDG-2 RECEPTOR ANTAGONIST
    Publication number: 20230295073
    Abstract: Described herein are methods of making crystalline Form 1 of 2-(4-methoxy-3-(3-methylphenethoxy)benzamido)-2,3-dihydro-1H-indene-2-carboxylic acid.
    Type: Application
    Filed: March 1, 2023
    Publication date: September 21, 2023
    Inventors: Denis BILLEN, Bénédicte MARTIN, Michelle O'MAHONY
  • Process for preparing 7H-pyrrolo[2,3-D]pyrimidine compounds
    Patent number: 9926327
    Abstract: Described herein are improved processes for the preparation of the 7H-pyrrolo[2,3-d]pyrimidine compound, N-methyl-1-{trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}-methanesulfonamide, intermediates thereof, and veterinary acceptable salts thereof.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: March 27, 2018
    Assignee: Zoetis Services LLC
    Inventors: Timothy Lee Stuk, Denis Billen, Valerie Sue Westrick, Vageesha Warnajith Liyana Gunawardana
  • PROCESS FOR PREPARING 7H-PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS
    Publication number: 20170233397
    Abstract: Described herein are improved processes for the preparation of the 7H-pyrrolo[2,3-d]pyrimidine compound, N-methyl-1-{trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}-methanesulfonamide, intermediates thereof, and veterinary acceptable salts thereof.
    Type: Application
    Filed: February 7, 2017
    Publication date: August 17, 2017
    Inventors: Timothy Lee Stuk, Denis Billen, Valerie Sue Westrick, Vageesha Warnajith Liyana Gunawardana
  • Crystalline forms of 1-(5?-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoro-methyl)-4,5-dihydroisoxazol-3-yl)-3?H-spiro[azetidine-3,1?-isobenzofuran]-1-yl)-2-(methylsulfonyl) ethanone
    Patent number: 9200003
    Abstract: The present invention relates to novel crystalline modifications of 1-(5?-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoro-methyl)-4,5-dihydroisoxazol-3-yl)-3?H-spiro[azetidine-3,1?-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone. The present invention also describes compositions and methods of treating a parasitic infection or infestation in an animal in need thereof. The present invention also relates to processes for making the crystalline forms.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: December 1, 2015
    Assignee: Zoetis Services LLC
    Inventors: Denis Billen, Matthew Joseph Birchmeier, Ronald J. VanderRoest
  • PHENICOL ANTIBACTERIALS
    Publication number: 20150266910
    Abstract: The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.
    Type: Application
    Filed: June 5, 2015
    Publication date: September 24, 2015
    Inventors: Michael Curtis, Brian A. Duclos, Richard A. Ewin, Paul D. Johnson, Timothy Allan Johnson, Rajendran Vairagoundar, Denis Billen, Richard M. Goodwin, Andrea K. Haber-Stuk, Graham M. Kyne, Susan M. K. Sheehan
  • CRYSTALLINE FORMS OF 1-(5'-(5-(3,5-DICHLORO-4-FLUOROPHENYL)-5-(TRIFLUORO-METHYL)-4,5-DIHYDROISOXAZOL-3-YL)-3'H-SPIRO[AZETIDINE-3,1'-ISOBENZOFURAN]-1-YL)-2-(METHYLSULFONYL)ETHANONE
    Publication number: 20150183795
    Abstract: The present invention relates to novel crystalline modifications of 1-(5?-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoro-methyl)-4,5-dihydroisoxazol-3-yl)-3?H-spiro[azetidine-3,1?-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone. The present invention also describes compositions and methods of treating a parasitic infection or infestation in an animal in need thereof. The present invention also relates to processes for making the crystalline forms.
    Type: Application
    Filed: August 28, 2013
    Publication date: July 2, 2015
    Inventors: Denis Billen, Matthew Joseph Birchmeier, Ronald J. VanderRoest
  • PROCESS FOR THE PREPARATION OF CHIRAL ISOXAZOLINE AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS
    Publication number: 20140371464
    Abstract: The invention recites a chiral process for the synthesis of isoxazoline azetidine phenyl substituted derivatives of Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, processes for making, and their use as a parasiticide in an animal.
    Type: Application
    Filed: January 29, 2013
    Publication date: December 18, 2014
    Inventors: Denis Billen, Sean David William Greenwood, Timothy Lee Stuk
  • PHENICOL ANTIBACTERIAL AGENTS
    Publication number: 20140088046
    Abstract: The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.
    Type: Application
    Filed: September 5, 2013
    Publication date: March 27, 2014
    Applicant: ZOETIS LLC
    Inventors: Denis Billen, Michael Curtis, Richard Andrew Ewin, Richard M. Goodwin, Paul D. Johnson, Timothy Allan Johnson, Graham M. Kyne, Todd M. Maddux, Susan Mary Kult Sheehan, Rajendran Vairagoundar
  • PHENICOL ANTIBACTERIALS
    Publication number: 20130237502
    Abstract: The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.
    Type: Application
    Filed: March 5, 2013
    Publication date: September 12, 2013
    Inventors: Michael Curtis, Brian A. Duclos, Richard A. Ewin, Paul D. Johnson, Timothy Allen Johnson, Rajendran Vairagoundar, Denis Billen, Richard M. Goodwin, Andrea K. Haber-Stuk, Graham M. Kyne, Susan M. K. Sheehan
  • Spirocyclic isoxazoline derivatives as antiparasitic agents
    Patent number: 8466115
    Abstract: The invention recites spirocyclic isoxazoline derivatives of Formula (V.1), Formula (V.2), Formula (V.1.1), and Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, processes for making, and their use as a parasiticide in an animal. The variables A, V, Z, W1, W2, W3, W, Y, X, R1a, R1b, R1c, R2, R3, R4, n, and “” are as described herein.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: June 18, 2013
    Assignee: Zoetis LLC
    Inventors: Michael Curtis, Sanjay Menon, Valerie A. Vaillancourt, Nathan Anthony Logan Chubb, Denis Billen, Sean David William Greenwood, Timothy Lee Stuk
  • SPIROCYCLIC ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS
    Publication number: 20120232026
    Abstract: The invention recites spirocyclic isoxazoline derivatives of Formula (V.1), Formula (V.2), Formula (V.1.1), and Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, processes for making, and their use as a parasiticide in an animal. The variables A, V, Z, W1, W2, W3, W, Y, X, R1a, R1b, R1c, R2, R3, R4, n, and “” are as described herein.
    Type: Application
    Filed: March 8, 2012
    Publication date: September 13, 2012
    Applicant: PFIZER INC.
    Inventors: Michael Curtis, Sanjay Menon, Valerie A. Vaillancourt, Nathan Anthony Logan Chubb, Denis Billen, Sean David William Greenwood, Timothy Lee Stuk
  • Substituted arylpyrazoles
    Patent number: 8084486
    Abstract: This invention relates to a combination product comprising a compound of formula I wherein X, R1, R2, R3, R4, R5, R6, R7 and R9 are as described herein, and one or more further biologically active compounds as described herein, particularly anti-parasitic agents.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: December 27, 2011
    Assignee: Pfizer Limited
    Inventors: Denis Billen, Nathan Anthony Logan Chubb, David Morris Gethin, Kim Thomas Hall, Lee Richard Roberts, Nigel Derek Arthur Walshe
  • SUBSTITUTED ARYLPYRAZOLES
    Publication number: 20110196011
    Abstract: This invention relates to a combination product comprising a compound of formula I wherein X, R1, R2, R3, R4, R5, R6, R7 and R9 are as described herein, and one or more further biologically active compounds as described herein, particularly anti-parasitic agents.
    Type: Application
    Filed: April 19, 2011
    Publication date: August 11, 2011
    Applicant: PFIZER LIMITED
    Inventors: Denis Billen, Nathan Anthony Logan Chubb, David Morris Gethin, Kim Thomas Hall, Lee Richard Roberts, Nigel Derek Arthur Walshe
  • Substituted arylpyrazoles
    Patent number: 7968584
    Abstract: This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.
    Type: Grant
    Filed: March 19, 2009
    Date of Patent: June 28, 2011
    Assignees: Pfizer Inc., Pfizer Products Inc.
    Inventors: Denis Billen, Jessica Boyle, Douglas James Critcher, David Morris Gethin, Kim Thomas Hall, Graham Michael Kyne
  • Substituted arylpyrazoles
    Patent number: 7960426
    Abstract: This invention relates to a combination product comprising a compound of formula I wherein X, R1, R2, R3, R4, R5, R6, R7 and R9 are as described herein, and one or more further biologically active compounds as described herein, particularly anti-parasitic agents.
    Type: Grant
    Filed: February 3, 2009
    Date of Patent: June 14, 2011
    Assignee: Pfizer Limited
    Inventors: Denis Billen, Nathan Anthony Logan Chubb, David Morris Gethin, Kim Thomas Hall, Lee Richard Roberts, Nigel Derek Arthur Walshe
  • Substituted arylpyrazoles
    Patent number: 7902232
    Abstract: This invention relates to a combination product comprising a range of 1-aryl-4 -cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, and one o more further therapeutic agents, particularly anti-parasitic agents.
    Type: Grant
    Filed: June 6, 2006
    Date of Patent: March 8, 2011
    Assignee: Pfizer Limited
    Inventors: Denis Billen, Nathan Anthony Logan Chubb, David Morris Gethin, Kim Thomas Hall, Lee Richard Roberts, Nigel Derek Arthur Walshe
  • Substituted arylpyrazoles
    Patent number: 7645786
    Abstract: This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.
    Type: Grant
    Filed: December 14, 2006
    Date of Patent: January 12, 2010
    Assignee: Pfizer Inc.
    Inventors: Denis Billen, Jessica Boyle, Douglas James Critcher, David Morris Gethin, Kim Thomas Hall, Graham Michael Kyne
  • SUBSTITUTED ARYLPYRAZOLES
    Publication number: 20090312371
    Abstract: This invention relates to a combination product comprising a range of 1-aryl-4-cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, and one o more further therapeutic agents, particularly anti-parasitic agents.
    Type: Application
    Filed: June 6, 2006
    Publication date: December 17, 2009
    Applicant: PFIZER LIMITED
    Inventors: Denis Billen, Nathan Anthony Chubb, David Morris Gethin, Kim Thomas Hall, Lee Richard Roberts, Nigel Derek Walshe
  • SUBSTITUTED ARYLPYRAZOLES
    Publication number: 20090186924
    Abstract: This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.
    Type: Application
    Filed: March 19, 2009
    Publication date: July 23, 2009
    Applicants: Pfizer Inc., Pfizer Products Inc..
    Inventors: Denis Billen, Jessica Boyle, Douglas James Critcher, David Morris Gethin, Kim Thomas Hall, Graham Michael Kyne
  • SUBSTITUTED ARYLPYRAZOLES
    Publication number: 20090137524
    Abstract: This invention relates to a combination product comprising a compound of formula I wherein X, R1, R2, R3, R4, R5, R6, R7 and R9 are as described herein, and one or more further biologically active compounds as described herein, particularly anti-parasitic agents.
    Type: Application
    Filed: February 3, 2009
    Publication date: May 28, 2009
    Inventors: Denis Billen, Nathan Anthony Logan Chubb, David Morris Gethin, Kim Thomas Hall, Lee Richard Roberts, Nigel Derek Arthur Walshe