Patents by Inventor Denis Labarre

Denis Labarre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9320804
    Abstract: The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K (I) wherein: K represents 0-Z or NH—Z, Z representing (CR2R3)m—CH3, (CH2—CH2—O)m—H, (CH2—CH2—O)m—CH3, (CH2)m—NR4R5 with m representing an integer from 1 to 30; R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: April 26, 2016
    Assignees: OCCLUGEL, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS-SUD 11, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, UNIVERSITE PARIS DIDEROT PARIS 7
    Inventors: Laurence Moine, Laurent Bedouet, Alexandre Laurent, Denis Labarre, Michel Wassef, Van Nga Nguyen
  • Patent number: 8673264
    Abstract: An injectable biomaterial containing a non-aqueous solvent suitable for injection to a human being and nanoparticles made of a polymer that is insoluble in water and insoluble in the non-aqueous solvent, in which the nanoparticles are loaded with a drug or a biological agent. The injectable biomaterial is suitable for occluding normal or malformative blood vessels or non-circulating cavities, or for necrosing tumors.
    Type: Grant
    Filed: March 2, 2010
    Date of Patent: March 18, 2014
    Assignee: Assistance Publique-Hopitaux de Paris
    Inventors: Minh Tam Baylatry, Anouk Bisdorf-Bresson, Denis Labarre, Alexandre Laurent, Laurence Moine, Jean-Pierre Saint-Maurice, Khelil Slimani, Michel Wassef
  • Publication number: 20120230937
    Abstract: The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K (I) wherein: K represents 0-Z or NH—Z, Z representing (CR2R3)m—CH3, (CH2—CH2—O)m—H, (CH2—CH2—O)m—CH3, (CH2)m—NR4R5 with m representing an integer from 1 to 30; R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker.
    Type: Application
    Filed: September 9, 2010
    Publication date: September 13, 2012
    Applicants: OCCLUGEL, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS DIDEROT PARIS 7, ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, UNIVERSITE PARIS-SUD 11
    Inventors: Laurence Moine, Laurent Bedouet, Alexandre Laurent, Denis Labarre, Michel Wassef, Van Nga Nguyen
  • Publication number: 20120195826
    Abstract: The invention relates to an injectable biomaterial. The injectable biomaterial of the invention comprises a non aqueous solvent which is compatible for injection to human being and nanoparticles made of a polymer which is insoluble in water and insoluble in said non aqueous solvent, said nanoparticles being loaded with a drug or a biological agent. The injectable biomaterial of the invention is particularly appropriate for occluding normal or malformative blood vessels or non circulating cavities or for necrosing tumors.
    Type: Application
    Filed: March 2, 2010
    Publication date: August 2, 2012
    Applicant: ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
    Inventors: Minh Tam Baylatry, Anouk Bisdorf-Bresson, Denis Labarre, Alexandre Laurent, Laurence Moine, Jean-Pierre Saint-Maurice, Khelil Slimani, Michel Wassef
  • Publication number: 20100260845
    Abstract: The present invention provides a biodegradable biopolymer matrix for surgical and/or therapeutic use comprising chitosan hydrochloride and dextran dialdehyde is in the ratio of 1:1 to 1:2. The invention further provides a process for preparing the biopolymer matrix and a kit for a surgical and/or therapeutic use comprising the biopolymer matrix.
    Type: Application
    Filed: December 8, 2008
    Publication date: October 14, 2010
    Applicant: Indo-French Center for the Promotion of Advanced Research
    Inventors: A. Jayakrishnan, Denis Labarre, Alexandre Laurent, Biji Balakrishnan, P.R. Umashankar
  • Patent number: 7407646
    Abstract: A charged biomaterial including at least one first hydrophilic polymer, and superparamagnetic iron oxide particles complexed with a second hydrophilic polymer substantially identical to or different from the first hydrophilic polymer, wherein the superparamagnetic iron oxide particles complexed with the second hydrophilic polymer are distributed substantially homogeneously and substantially without aggregates in the first hydrophilic polymer. A process for preparing a charged biomaterial including forming an aqueous solution of hydrophilic monomers and superparamagnetic iron oxide particles complexed with a hydrophilic polymer including monomers substantially identical to or different from the hydrophilic monomers, polymerizing the solution and forming a polymer hydrogel in which are distributed substantially homogeneously and substantially without aggregates the superparamagnetic iron oxide particles complexed with the hydrophilic polymer.
    Type: Grant
    Filed: October 23, 2002
    Date of Patent: August 5, 2008
    Assignee: L'Assistance Publique-Hopitaux de Paris Etablissement Public de Sante
    Inventors: Alexandre Laurent, Denis Labarre
  • Publication number: 20060210635
    Abstract: The invention relates to injectable gel-forming compositions which contain an association of linear and cross-linked polymers and are embodied in the form of a suspension. The use of said compositions, in particular for filling pipes and cavities is also disclosed.
    Type: Application
    Filed: January 5, 2004
    Publication date: September 21, 2006
    Applicants: ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, UNIVERSITE PARIS SUD XI
    Inventors: Alexandre Laurent, Denis Labarre, Jiri Labsky, Jiri Honiger, Rene Chapot, Michel Wassef, Aymeric Seron
  • Publication number: 20060182807
    Abstract: The invention relates to novel compounds, characterized in that they comprise a hemoprotein which is associated with a sequenced block copolymer, comprising an hydrophilic segment which is an oligo or polysaccharide linked to at least one hydrophobic segment of formula (1) wherein x represents H or an radical which is alkyl, CN or CONHR, Y represents a COOR?, CONHR? or C6H5 radical, wherein R, R? and R? represent, independently from each other, a hydrogen atom, a C1-C20 linear ou branched alkyl group, a C1-C20 linear or branched alcoxy group, an amino acid radical, a mono- or poly-hydroxyl acid radical or an aryl ou heteroaryl C5-C12 radical, and forms associated with a gas. The invention can be used as blood substitutes and depolluting agents.
    Type: Application
    Filed: June 10, 2003
    Publication date: August 17, 2006
    Inventors: Christine Vauthier, Cedric Chauvierre, Patrick Couvreur, Denis Labarre, Liliane Leclerc, Michael Marden
  • Patent number: 7014845
    Abstract: The invention relates to cross-linked copolymers based on non cross-linked polycarboxylic copolymers, said non cross-linked copolymers containing at least one polysaccharide. The invention also relates to a process for the preparation of these copolymers and their use in particular as a support in pharmaceutical compositions.
    Type: Grant
    Filed: October 3, 2000
    Date of Patent: March 21, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S)
    Inventors: Denis Labarre, Nada Lambert, Cathy Ducos, Françis Diancourt
  • Publication number: 20040071776
    Abstract: The invention concerns porous polymeric biomaterials containing a porous polymeric matrix optionally filled with biological and/or chemical active agents, the method for preparing same and their uses, in particular as implant.
    Type: Application
    Filed: November 7, 2003
    Publication date: April 15, 2004
    Inventors: Vincent Boudy, Alexandre Laurent, Denis Labarre, Jean-Claude Chaumeil
  • Publication number: 20040028635
    Abstract: A block-structure copolymer consisting of a hydrophilic saccharide segment and at least a biodegradable hydrophobic segment of general formula (I), 1
    Type: Application
    Filed: May 15, 2003
    Publication date: February 12, 2004
    Inventors: Cedric Chauvierre, Patrick Couvreur, Denis Labarre, Christine Vauthier
  • Publication number: 20030077225
    Abstract: A charged biomaterial including at least one first hydrophilic polymer, and superparamagnetic iron oxide particles complexed with a second hydrophilic polymer substantially identical to or different from the first hydrophilic polymer, wherein the superparamagnetic iron oxide particles complexed with the second hydrophilic polymer are distributed substantially homogeneously and substantially without aggregates in the first hydrophilic polymer. A process for preparing a charged biomaterial including forming an aqueous solution of hydrophilic monomers and superparamagnetic iron oxide particles complexed with a hydrophilic polymer including monomers substantially identical to or different from the hydrophilic monomers, polymerizing the solution and forming a polymer hydrogel in which are distributed substantially homogeneously and substantially without aggregates the superparamagnetic iron oxide particles complexed with the hydrophilic polymer.
    Type: Application
    Filed: October 23, 2002
    Publication date: April 24, 2003
    Applicant: X-BIO
    Inventors: Alexandre Laurent, Denis Labarre
  • Patent number: 6229009
    Abstract: A cross-linked copolymer based on at least one non-crosslinked polycarboxylic polysaccharide and at least one second non-crosslinked polycarboxylic polymer which is not a polycarboxylic polysaccharide and a cross-linking agent having at least two amine functions.
    Type: Grant
    Filed: February 18, 1999
    Date of Patent: May 8, 2001
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Nada Lambert, Denis Labarre, Hatem Fessi