Patents by Inventor Dennis Mulvey

Dennis Mulvey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes and intermediates for phosphorous-containing covalent linkages
    Patent number: 6124450
    Abstract: Synthetic processes are provided wherein substituted silylalkyl phosphoramidites serve as coupling reagents for preparing phosphate, phosphorothioate, and other phosphorous-containing covalent linkages. Also provided are synthetic intermediates useful in such processes.
    Type: Grant
    Filed: July 27, 1998
    Date of Patent: September 26, 2000
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Dennis Mulvey, Douglas L. Cole, Phillip Dan Cook
  • Monomeric and dimeric nucleosides with silyl-containing diamino phosphorous linkages
    Patent number: 5847106
    Abstract: Synthetic processes are provided wherein substituted silylalkyl phosphoramidites serve as coupling reagents for preparing phosphate, phosphorothioate, and other phosphorous-containing covalent linkages. Also provided are synthetic intermediates useful in such processes. h processes.
    Type: Grant
    Filed: January 27, 1997
    Date of Patent: December 8, 1998
    Assignee: ISIS Pharmaceuticals Inc.
    Inventors: Vasulinga Ravikumar, Dennis Mulvey, Douglas L. Cole, Phillip Dan Cook
  • Use of carbocation scavenger during oligonucleotide synthesis
    Patent number: 5714597
    Abstract: During the synthesis of oligonucleotides and phosphate linked oligomers, a carbocation scavenging agent is employed to increase the overall yield. The carbocation scavenging agent is used in conjunction with an acidic solution employed during the deprotection step.
    Type: Grant
    Filed: March 8, 1996
    Date of Patent: February 3, 1998
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Mark Andrade, Dennis Mulvey, Douglas L. Cole
  • Process for preparing oligonucleotides using silyl-containing diamino phosphorous reagents
    Patent number: 5614621
    Abstract: Synthetic processes are provided wherein substituted silylalkyl phosphoramidites serve as coupling reagents for preparing phosphate, phosphorothioate, and other phosphorous-containing covalent linkages. Also provided are synthetic intermediates useful in such processes.
    Type: Grant
    Filed: July 29, 1993
    Date of Patent: March 25, 1997
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Dennis Mulvey, Douglas L. Cole, Phillip D. Cook
  • Carbocation scavenging during oligonucleotide synthesis
    Patent number: 5510476
    Abstract: During the synthesis of oligonucleotides and phosphate linked oligomers, a carbocation scavenging agent is employed to increase the overall yield. The carbocation scavenging agent is used in conjunction with an acidic solution employed during the deprotection step.
    Type: Grant
    Filed: July 7, 1994
    Date of Patent: April 23, 1996
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Mark Andrade, Dennis Mulvey, Douglas L. Cole
  • 2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin
    Patent number: 4195023
    Abstract: Certain novel acyl saccharins and acyl 3-oxo-1,2-benzisothiazolines, their preparation, pharmaceutical compositions and novel methods of inhibiting elatase and treating emphysema are disclosed.
    Type: Grant
    Filed: August 20, 1975
    Date of Patent: March 25, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Dennis Mulvey, Howard Jones, Morris Zimmerman