Abstract: The present invention provides methods for fabricating optical fiber preforms and optical fibers. According to one embodiment of the invention, a method for making an optical fiber preform includes the steps of providing at least one sacrificial rod having an outside surface; forming a material on the outside surface of each sacrificial rod to yield a structured body, the structured body including a structured material in substantial contact with the at least one sacrificial rod; removing each sacrificial rod from the structured body; and including the structured body in the optical fiber preform. The preform may be drawn into an optical fiber. The methods of the present invention are especially useful in the fabrication of microstructured optical fibers.