Patents by Inventor Dennis W. Solas

Dennis W. Solas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9370629
    Abstract: Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance, by optical ignition or by percussion. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: June 21, 2016
    Assignee: ALEXZA PHARMACEUTICALS, INC.
    Inventors: Ramesh Damani, Ron L. Hale, Daniel J. Myers, Reynaldo J. Quintana, Dennis W. Solas, Soonho Song, Pravin Soni, Curtis Tom, Krishnamohan Sharma
  • Publication number: 20160108529
    Abstract: There are provided methods and systems for an electrochemical cell including an anode and a cathode where the anode is contacted with a metal ion that converts the metal ion from a lower oxidation state to a higher oxidation state. The metal ion in the higher oxidation state is reacted with hydrogen gas, an unsaturated hydrocarbon, and/or a saturated hydrocarbon to form products.
    Type: Application
    Filed: October 9, 2015
    Publication date: April 21, 2016
    Inventors: Thomas A. Albrecht, Ryan J. Gilliam, Bryan Boggs, Kyle Self, Dennis W. Solas, Michael Kostowskyj, Margarete K. Leclerc, Alexander Gorer, Michael Joseph Weiss
  • Publication number: 20160040304
    Abstract: There are provided methods and systems for an electrochemical cell including an anode and a cathode where the anode is contacted with a metal ion that converts the metal ion from a lower oxidation state to a higher oxidation state. The metal ion in the higher oxidation state is reacted with hydrogen gas, an unsaturated hydrocarbon, and/or a saturated hydrocarbon to form products.
    Type: Application
    Filed: October 7, 2015
    Publication date: February 11, 2016
    Inventors: Thomas A. Albrecht, Ryan J. Gilliam, Kyle Self, Dennis W. Solas, Margarete K. Leclerc
  • Publication number: 20150361564
    Abstract: There are provided methods and systems for an electrochemical cell including an anode and a cathode where the anode is contacted with a metal ion that converts the metal ion from a lower oxidation state to a higher oxidation state. The metal ion in the higher oxidation state is reacted with hydrogen gas, an unsaturated hydrocarbon, and/or a saturated hydrocarbon to form products.
    Type: Application
    Filed: August 24, 2015
    Publication date: December 17, 2015
    Inventors: Thomas A. Albrecht, Ryan J. Gilliam, Kyle Self, Dennis W. Solas, Margarete K. Leclerc, Michael Joseph Weiss
  • Patent number: 9187834
    Abstract: There are provided methods and systems for an electrochemical cell including an anode and a cathode where the anode is contacted with a metal ion that converts the metal ion from a lower oxidation state to a higher oxidation state. The metal ion in the higher oxidation state is reacted with hydrogen gas, an unsaturated hydrocarbon, and/or a saturated hydrocarbon to form products.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: November 17, 2015
    Assignee: Calera Corporation
    Inventors: Thomas A. Albrecht, Ryan J. Gilliam, Bryan Boggs, Kyle Self, Dennis W. Solas, Michael Kostowskyj, Margarete K. Leclerc, Alexander Gorer, Michael Joseph Weiss
  • Patent number: 9187835
    Abstract: There are provided methods and systems for an electrochemical cell including an anode and a cathode where the anode is contacted with a metal ion that converts the metal ion from a lower oxidation state to a higher oxidation state. The metal ion in the higher oxidation state is reacted with hydrogen gas, an unsaturated hydrocarbon, and/or a saturated hydrocarbon to form products.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: November 17, 2015
    Assignee: Calera Corporation
    Inventors: Thomas A. Albrecht, Ryan J. Gilliam, Bryan Boggs, Kyle Self, Dennis W. Solas, Michael Kostowskyj, Margarete K. Leclerc, Alexander Gorer, Michael Joseph Weiss
  • Publication number: 20150265783
    Abstract: Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance, by optical ignition or by percussion. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.
    Type: Application
    Filed: March 31, 2015
    Publication date: September 24, 2015
    Inventors: Ramesh Damani, Ron L. Hale, Daniel J. Myers, Reynaldo J. Quintana, Dennis W. Solas, Soonho Song, Pravin Soni, Curtis Tom, Krishnamohan Sharma
  • Patent number: 8991387
    Abstract: Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance, by optical ignition or by percussion. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: March 31, 2015
    Assignee: Alexza Pharmaceuticals, Inc.
    Inventors: Ramesh Damani, Ron L. Hale, Daniel J. Myers, Reynaldo J. Quintana, Dennis W. Solas, Soonho Song, Pravin Soni, Curtis Tom, Krishnamohan Sharma
  • Patent number: 8387612
    Abstract: Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance, by optical ignition or by percussion. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: March 5, 2013
    Assignee: Alexza Pharmaceuticals, Inc.
    Inventors: Ramesh Damani, Ron L. Hale, Daniel J. Myers, Reynaldo J. Quintana, Dennis W. Solas, Soonho Song, Pravin Soni, Curtis Tom, Kirshnamohan Sharma
  • Publication number: 20120292196
    Abstract: There are provided methods and systems for an electrochemical cell including an anode and a cathode where the anode is contacted with a metal ion that converts the metal ion from a lower oxidation state to a higher oxidation state. The metal ion in the higher oxidation state is reacted with hydrogen gas, an unsaturated hydrocarbon, and/or a saturated hydrocarbon to form products.
    Type: Application
    Filed: May 17, 2012
    Publication date: November 22, 2012
    Inventors: Thomas A. Albrecht, Ryan J. Gilliam, Bryan Boggs, Kyle Self, Dennis W. Solas, Michael Kostowskyj, Margarete K. Leclerc, Alexander Gorer, Michael Joseph Weiss
  • Publication number: 20120292197
    Abstract: There are provided methods and systems for an electrochemical cell including an anode and a cathode where the anode is contacted with a metal ion that converts the metal ion from a lower oxidation state to a higher oxidation state. The metal ion in the higher oxidation state is reacted with hydrogen gas, an unsaturated hydrocarbon, and/or a saturated hydrocarbon to form products.
    Type: Application
    Filed: May 17, 2012
    Publication date: November 22, 2012
    Inventors: Thomas A. Albrecht, Ryan J. Gilliam, Bryan Boggs, Kyle Self, Dennis W. Solas, Michael Kostowskyj, Margarete K. Leclerc, Alexander Gorer, Michael Joseph Weiss
  • Patent number: 7923662
    Abstract: High sparking initiator compositions with a controlled amount of power are disclosed. The initiator compositions comprise a metal containing oxidizing agent, at least one metal reducing agent, and a non-explosive binder. Low voltage igniters that provide bidirectional plumes upon ignition are also disclosed. These igniters have a electrically resistive element positioned across a hole in a support which directs the plume. These igniters and compositions are useful in the actuation of solid fuel heating unit, in particular, sealed heating units.
    Type: Grant
    Filed: January 17, 2008
    Date of Patent: April 12, 2011
    Assignee: Alexza Pharmaceuticals, Inc.
    Inventors: Ron L. Hale, Mingzu Lei, Hilary N. Pettit, Dennis W. Solas, Soonho Song, Curtis Tom
  • Publication number: 20100006092
    Abstract: Aerosol drug delivery devices incorporating percussively activated heat packages are disclosed. The heat packages include a percussive igniter and a fuel capable of undergoing an exothermic oxidation-reduction reaction when ignited by the percussive igniter. The drug delivery devices disclosed can be activated by an actuation mechanism to vaporize a thin solid film comprising a drug disposed on the exterior of a hat package. Metal coordination complexes of volatile drugs, and in particular nicotine, from which the drug can be selectively vaporized when heated are also disclosed. The use of aerosol drug delivery devices comprising thin films of nicotine metal salt complexes for the treatment of nicotine craving and for effecting smoking cessation are also disclosed.
    Type: Application
    Filed: August 28, 2009
    Publication date: January 14, 2010
    Applicant: ALEXZA PHARMACEUTICALS, INC.
    Inventors: Ron L. Hale, Mingzu Lei, Peter M. Lloyd, Patrik Munzar, C.V. Krishnamohan Sharma, Dennis W. Solas, Matthew D. Stracker
  • Patent number: 7645442
    Abstract: A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300° C., and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.
    Type: Grant
    Filed: August 4, 2003
    Date of Patent: January 12, 2010
    Assignee: Alexza Pharmaceuticals, Inc.
    Inventors: Ron L. Hale, Peter M. Lloyd, Amy Lu, Daniel J. Myers, Reynaldo J. Quintana, Joshua D. Rabinowitz, Dennis W. Solas, Soonho Song, Curtis Tom, Martin J. Wensley
  • Publication number: 20090301363
    Abstract: Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance, by optical ignition or by percussion. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.
    Type: Application
    Filed: June 16, 2009
    Publication date: December 10, 2009
    Applicant: ALEXZA PHARMACEUTICALS, INC.
    Inventors: Ramesh Damani, Ron L. Hale, Daniel J. Myers, Reynaldo J. Quintana, Dennis W. Solas, Soonho Song, Pravin Soni, Curtis Tom, Kirshnamohan Sharma
  • Patent number: 7581540
    Abstract: Aerosol drug delivery devices incorporating percussively activated heat packages are disclosed. The heat packages include a percussive igniter and a fuel capable of undergoing an exothermic oxidation-reduction reaction when ignited by the percussive igniter. The drug delivery devices disclosed can be activated by an actuation mechanism to vaporize a thin solid film comprising a drug disposed on the exterior of a hat package. Metal coordination complexes of volatile drugs, and in particular nicotine, from which the drug can be selectively vaporized when heated are also disclosed. The use of aerosol drug delivery devices comprising thin films of nicotine metal salt complexes for the treatment of nicotine craving and for effecting smoking cessation are also disclosed.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: September 1, 2009
    Assignee: Alexza Pharmaceuticals, Inc.
    Inventors: Ron L. Hale, Mingzu Lei, Peter M. Lloyd, Patrik Munzar, Krishnamohan Sharma, Dennis W. Solas, Matthew D. Stracker
  • Patent number: 7498019
    Abstract: The present invention relates to the delivery of migraine headache drugs through an inhalation route. Specifically, it relates to aerosols containing migraine headache drugs that are used in inhalation therapy.
    Type: Grant
    Filed: March 21, 2006
    Date of Patent: March 3, 2009
    Assignee: Alexza Pharmaceuticals, Inc.
    Inventors: Ron L. Hale, Joshua D. Rabinowitz, Dennis W. Solas, Alejandro C. Zaffaroni
  • Publication number: 20080306285
    Abstract: Disclosed herein are heat-labile prodrugs, their preparation and uses.
    Type: Application
    Filed: April 28, 2008
    Publication date: December 11, 2008
    Applicant: ALEXZA PHARMACEUTICALS, INC.
    Inventors: Ron L. Hale, Dennis W. Solas, Kathleen Simis, Amy T. Lu, Peter M. Lloyd
  • Publication number: 20080227653
    Abstract: The present invention provides methods for comparing and identifying differences in nucleic acid sequences using a plurality of sequence specific recognition reagents (i.e., probes comprising a nucleic acid complementary to a nucleic acid sequence in collections to be compared) bound to a solid surface.
    Type: Application
    Filed: April 19, 2006
    Publication date: September 18, 2008
    Inventors: Stephen P.A. Fodor, Dennis W. Solas, William J. Dower
  • Patent number: 7402777
    Abstract: High sparking initiator compositions with a controlled amount of power are disclosed. The initiator compositions comprise a metal containing oxidizing agent, at least one metal reducing agent, and a non-explosive binder. Low voltage igniters that provide bidirectional plumes upon ignition are also disclosed. These igniters have a electrically resistive element positioned across a hole in a support which directs the plume. These igniters and compositions are useful in the actuation of solid fuel heating unit, in particular, sealed heating units.
    Type: Grant
    Filed: May 20, 2004
    Date of Patent: July 22, 2008
    Assignee: Alexza Pharmaceuticals, Inc.
    Inventors: Hale L. Ron, Mingzu Lei, Hilary N. Pettit, Dennis W. Solas, Soonho Song, Curtis Tom