Patents by Inventor Detlev Sülzle

Detlev Sülzle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES
    Publication number: 20150087631
    Abstract: The present invention relates to amino-substituted imidazopyridazine compounds of general formula (I), in which A, R1, R2, R3, R4, R5 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: March 27, 2013
    Publication date: March 26, 2015
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Knut Eis, Florian Puehler, Ludwig Zorn, Volker Schulze, Detlev Sülzle, Philip Lienau, Andrea Hägebarth, Kirstin Petersen, Ulf Bömer
  • AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES
    Publication number: 20140364435
    Abstract: The present invention relates to amino-substituted imidazopyndazine compounds of general formula (I): in which A, R1, R2, R3, R4 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: December 10, 2012
    Publication date: December 11, 2014
    Inventors: Knut Eis, Florian Puehler, Ludwig Zorn, Volker Schulze, Detlev Sülzle, Philip Lienau, Andrea Hagebarth, Kirstin Petersen, Ulf Bomer
  • Enantiomer-pure (4S,8S)- and (4R,8R)-4-p-Nitrobenzyl-8-methyl-3,6,9-triaza-3N,6N,9N-tricarboxymethyl-1,11-undecanedioic Acid and Derivatives Thereof, Process for their Production and Use for the Production of Pharmaceutical Agents
    Publication number: 20120064002
    Abstract: Enantiomer-pure compounds of general formulas VIIa and VIIb in which A stands for a group —COO—, and Z and R have different meanings, as well as use thereof are described.
    Type: Application
    Filed: March 31, 2011
    Publication date: March 15, 2012
    Inventors: Lutz LEHMANN, Matthias FRIEBE, Thomas BRUMBY, Detlev SUELZLE, Johannes PLATZEK
  • NOVEL [F-18]- LABELLED L-GLUTAMIC ACID AND L-GLUTAMINE DERIVATIVES (I), USE THEREOF AND METHOD FOR THEIR PRODUCTION
    Publication number: 20110165076
    Abstract: What is described are the compounds and the synthesis of [F-18]-labelled L-glutamic acid, [F-18]-labelled L-glutamate, their derivatives of the formula (I) and their use.
    Type: Application
    Filed: May 14, 2009
    Publication date: July 7, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Ludger Dinkelborg, Mathias Berndt, Matthias Friebe, Heribert Schmitt-Willich, Detlev Sülzle, Norman Koglin
  • Macrocyclic metal complexes and their use for the production of conjugates with biomolecules
    Patent number: 7164016
    Abstract: The invention relates to macrocyclic metal complexes and their production and use for the production of conjugates with biomolecules. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning of the relaxivity is made possible.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: January 16, 2007
    Assignee: Schering AG
    Inventors: Johannes Platzek, Heribert Schmitt-Willich, Günther Michl, Thomas Frenzel, Detlev Sülzle, Hans Bauer, Bernd Radüchel, Hanns-Joachim Weinmann, Heiko Schirmer
  • Hydroxypyridinone derivatives, metal complexes thereof and the use thereof for preparing conjugates with biomolecules
    Publication number: 20070003484
    Abstract: The invention relates to hydroxypyridinone derivatives, their metal complexes, their preparation and their use for preparing conjugates with biomolecules. The conjugates are suitable as contrast agents in NMR diagnosis. A high relaxivity is achieved and the NMRD maximum is raised through a specific design of the ligands.
    Type: Application
    Filed: December 20, 2005
    Publication date: January 4, 2007
    Inventors: Heribert Schmitt-Willich, Heiko Schirmer, Johannes Platzek, Stephane Dumas, Vincent Jacques, Thomas Brumby, Detlev Suelzle, Bernd Misselwitz
  • Conjugates of hydroxypyridinone derivative metal complexes with biomolecules and their use for MRI diagnosis
    Publication number: 20060292079
    Abstract: The invention relates to conjugates of hydroxypyridinone derivative metal complexes and to their preparation. The conjugates are suitable as contrast agents in NMR diagnosis. A high relaxivity is achieved and the NMRD maximum is raised through a specific design of the ligands.
    Type: Application
    Filed: December 20, 2005
    Publication date: December 28, 2006
    Inventors: Heribert Schmitt-Willich, Heiko Schirmer, Johannes Platzek, Stephane Dumas, Vincent Jacques, Thomas Brumby, Detlev Suelzle, Bernd Misselwitz
  • Benzoxazine and benzothiazine derivatives and the use thereof in medicaments
    Patent number: 7141566
    Abstract: The invention relates to compounds of formula (I), the tautomeric and isomeric forms and salts thereof, in addition to a method for production and use thereof in medicaments.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: November 28, 2006
    Assignee: Schering Aktiengesellschaft
    Inventors: Peter Hölscher, Hartmut Rehwinkel, Stefan Jaroch, Detlev Sülzle, Margrit Hillmann, Gerardine Anne Burton, Fiona Mcdougall McDonald
  • Aminoalkyl-3, 4-dihydroquinoline derivatives as no-synthase inhibitors
    Patent number: 7067667
    Abstract: 3,4-dihydroquinoline derivatives, a process for their production and their use in pharmaceutical agents.
    Type: Grant
    Filed: October 29, 2003
    Date of Patent: June 27, 2006
    Assignee: Schering Aktiengesellschaft
    Inventors: Stefan Jaroch, Hartmut Rehwinkel, Peter Holscher, Detlev Sülzle, Margrit Hillmann, Gerardine Anne Burton, Fiona Mcdougall McDonald
  • Aromatic sulfonamides as peroxynitrite-rearrangement catalysts
    Publication number: 20050288324
    Abstract: The invention relates to the use of aromatics sulfonamides of the general formula I as peroxynitrite rearrangement catalysts, to the preparation thereof and to the use thereof as medicament for the treatment of various disorders.
    Type: Application
    Filed: August 4, 2005
    Publication date: December 29, 2005
    Inventors: Thorsten Blume, Roland Neuhaus, Detlev Suelzle, Iris Pribilla, Gisbert Depke, Joseph Beckman
  • Aromatic sulfonamides as peroxynitrite-rearrangement catalysts
    Patent number: 6946466
    Abstract: The invention relates to the use of aromatics sulfonamides of the general formula I as peroxynitrite rearrangement catalysts, to the preparation thereof and to the use thereof as medicament for the treatment of various disorders.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: September 20, 2005
    Assignee: Schering AG
    Inventors: Thorsten Blume, Roland Neuhaus, Detlev Suelzle, Iris Pribilla, Gisbert Depke, Joseph S. Beckman
  • Benzoxazine and benzothiazine derivatives and the use thereof in medicaments
    Patent number: 6914059
    Abstract: Compounds of formula I, their tautomeric and isomeric forms and salts, as well as the process for their production and their use in pharmaceutical agents are described.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: July 5, 2005
    Assignee: Schering AG
    Inventors: Hartmut Rehwinkel, Peter Hoelscher, Stefan Jaroch, Detlev Suelzle, Margrit Hillmann, Gerardine Anne Burton, Fiona Mcdonald McDonald
  • Novel amidine derivatives and the use of the same in pharmaceuticals
    Publication number: 20050119481
    Abstract: Amidine derivatives of formula I, their tautomeric and isomeric forms and salts as well as the process for their production and their use for the production of a pharmaceutical agent are described.
    Type: Application
    Filed: December 10, 2002
    Publication date: June 2, 2005
    Inventors: Hartmut Rehwinkel, Peter Hoelscher, Stefan Jaroch, Detlev Suelzle, Margrit Hillmann, Gerardine Burton, Fiona McDonald
  • Benzoxazine and benzothiazine derivatives and their use in medicines
    Patent number: 6841550
    Abstract: The invention relates to compounds of formula (I) and their tautomeric and isomeric forms and salts, as well as to a method for producing said compounds and their use in medicines.
    Type: Grant
    Filed: September 16, 1999
    Date of Patent: January 11, 2005
    Assignee: Schering Aktiengesellschaft
    Inventors: Peter Hölscher, Hartmut Rehwinkel, Stefan Jaroch, Detlev Sülzle, Margrit Hillmann, Gerardine Anne Burton, Fiona Mcdougall McDonald
  • Enantiomer-pure (4S,8S)- and (4R,8R)-4-p-nitrobenzyl-8-methyl-3,6,9-triaza-3N,6N,9N-tricarboxymethyl-1,11-undecanedioic acid and derivatives thereof, process for their production and use for the production of pharmaceutical agents
    Publication number: 20040208828
    Abstract: Enantiomer-pure compounds of general formulas VIIa and VIIb 1
    Type: Application
    Filed: February 4, 2004
    Publication date: October 21, 2004
    Inventors: Lutz Lehmann, Matthias Friebe, Thomas Brumby, Detlev Suelzle, Johannes Platzek
  • Aromatic sulfonamides as peroxynitrite-rearrangement catalysts
    Publication number: 20040204452
    Abstract: The invention relates to the use of aromatics sulfonamides of the general formula I as peroxynitrite rearrangement catalysts, to the preparation thereof and to the use thereof as medicament for the treatment of various disorders.
    Type: Application
    Filed: April 10, 2003
    Publication date: October 14, 2004
    Applicant: Schering AG
    Inventors: Thorsten Blume, Roland Neuhaus, Detlev Suelzle, Iris Pribilla, Gisbert Depke, Joseph S. Beckman
  • Peroxynitrite rearrangement catalysts
    Publication number: 20040127479
    Abstract: The invention relates to the use of paramagnetic 3-, 8-substituted porphyrin derivatives with various substituents in 13- and 17-positions of the porphyrin skeleton as peroxynitrite rearrangement catalysts.
    Type: Application
    Filed: August 27, 2003
    Publication date: July 1, 2004
    Applicant: Merck Patent GmbH
    Inventors: Gisbert Depke, Margrit Hillmann, Guenter Michl, Johannes Platzek, Detlev Suelzle, Roland Neuhaus
  • Fluorinated 3,4-dihydroquinoline derivatives used as NOS inhibitors
    Patent number: 6579883
    Abstract: The invention relates to compounds of formula (I), to a method for producing them and to their use in medicaments as NOS inhibitors.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: June 17, 2003
    Assignee: Schering Aktiengesellschaft
    Inventors: Stefan Jaroch, Hartmut Rehwinkel, Peter Hölscher, Detlev Sülzle, Margrit Hillmann, Gerardine Anne Burton, Fiona Macdougall McDonald
  • Perfluoroalkylamides, their production and their use in diagnosis
    Patent number: 6461587
    Abstract: The invention relates to macrocyclic perfluoroalkylamides, their production and their use in diagnosis.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: October 8, 2002
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Niedballa, Detlev Suelzle, Wolfgang Schlecker, Bernd Raduechel, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Benzoxazine and benzothiazine derivatives and their use in pharmaceuticals
    Patent number: 6365736
    Abstract: Described are benzoxazine and benzothiazine compounds of the formula I defined herein, methods for their preparation and methods for their use in pharmaceuticals based on their activity as NO-synthases (NOS) inhibitors.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: April 2, 2002
    Assignee: Schering Aktiengesellschaft
    Inventors: Peter Hölscher, Hartmut Rehwinkel, Stefan Jaroch, Detlev Suelzle